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The relationship between antimicrobial consumption and the rates of resistance of klebsiela pneumoniae in respiratory unit

The relationship between antimicrobial consumption and the r...

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两岸三地药理学与临床药理学术会议

作者： YANG Xin-yun~1 ZHUO Chao~2 XIAO Xiang-lin~1 YUAN Jin-Ping~2 YANG Ling~2 (1.First Affiliated Hospital of Guangzhou Medical College, Guangzhou 510120, China 2.Guangzhou Institute of Respiratory Disease, Guangzhou 510120, China)

Objective To investigate the relationship between the consumption of antibacterial agents and re- sistance rate of klebsiela pneumoniae(KP)in the hospital respiratory unit for 3 consecutive years in 2005- *** The total antibacterial consumption expressed as defined DDDs/100BD,as well as resistance rate of total KP and producing ESBLs KP were collected,and their correlation was *** The rate of resistance of KP to cefoperazone/sulbactam,Cefepime,Imipenem,Moxifloxacin was significantly positively associated with the consumption of Cefotaxime,Ceftazidime,Moxifloxacin,Amikacin respectively;A significant positive association was observed between the rate of resistance of KP to Piperacillin/Tazobac- tam,Ceftriaxone and the consumption of Imipenem;The rate of resistance of KP to Piperacillin,Cefo- taxime,Ciprofloxacin was significantly positively associated with the consumption of *** producing bacilli of KP were detected in 44 of 75 isolates (58.7%),The rate of resistance of producing ES- BLs KP to Piperacillin/Tazobactam,Ceftriaxone was significantly positively associated with the consump- tion of Imipenem,Ceftazidime;A significant positive association was observed between the rate of resistance of producing ESBLs KP to Piperacillin,Imipenem and the consumption of *** was no sig- nificant correlation in other *** A relationship existed between antimicrobial consumption and rates of resistance of KP in the hospital respiratory *** must use antibiotics carefully and with rea- son to control and lessen the drug resistance of bacterial.

关键词： klebsiela pneumoniae extended spectrumβlactamases drug resistance consumption of antibacterial agents relationship

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