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Protective effects of kidney-tonifying chinese herbal preparation on substantia nigra neurons in a mouse model of Parkinson's disease

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Neural Regeneration Research 2012年第6期7卷 413-420页

作者： Jing Cai Yun Tian Ruhui Lin Xuzheng Chen Zhizhen Liu Jindong Xie Academy of Integrative Medicine Fujian University of Traditional Chinese Medicine Fuzhou 350108 Fujian Province China College of Pharmaceutical Sciences Zhejiang University Hangzhou 310058 Zhejiang Province China

The chinese herbs Herba Epimedii, Fructus Ligustri Lucidi and Rhizoma Polygonati were injected into Parkinson＇s disease mice established via intraperitoneal injection of 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine hydrochloride. The selective monoamine oxidase B inhibitor selegiline was used as a positive control drug. After successive administration for 4 weeks, Herba Epimedii could downregulate the expression of caspase-3 and increase the brain-derived neurotrophic factor level, as well as increase tyrosine hydroxylase activity in the substantia nigra of Parkinson＇s disease mouse models. Rhizoma Polygonaticould downregulate the expression of caspase-3 and FasL, and increase neural growth factor and brain-derived neurotrophic factor levels. Fructus Ligustn Lucidi could downregulate caspase-3 expression. Rhizoma Polygonati and Fructus Ligustn Lucidi did not produce obvious effects on tyrosine hydroxylase activity. Herba Epimedii and Fructus Ligustri Lucidi yielded similar effects on apoptosis-promoting factors to those elicited by selegiline. Herba Epimedii and Rhizoma Polygonati significantly increased the levels of neurotrophic factors compared with selegiline. Herba Epimedii significantly increased tyrosine hydroxylase activity compared with selegiline. It is indicated that the kidney-tonifying chinese herbal preparation can downregulate the expression of apoptosis-promoting factors, increase neurotrophic factors levels in the substantia nigra and striatum, as well as increase tyrosine hydroxylase activity in the substantia nigra of Parkinson＇s disease mouse models, thereby exerting a stronger or similar neuroprotective effects compared with selegiline.

关键词： kidney-tonifying chinese herbal preparation Herba Epimedii Fructus Ligustri Lucidi Rhizoma Polygonati Parkinson's disease substantia nigra and striatum substantia nigra neuron neural regeneration

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