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中华口腔医学会第14次全国口腔医学学术会议（2012年会）

作者： School of stomotology,Capital Medical University Postgraduate student:Liu Aishu

Objective: keratocystic odontogenic tumor(KCOT)seriously endanger the health of the *** this study,the X-ray examination,pathology and immunohistochemical were performed for studying the changes in epithelial cell before and after decompression. Through cultivating and transforming of epithelial cells of KCOT,to study the biological characteristics of epithelial cells,and try to approach the therapeutic mechanism of decompression,and provide the theoretical basis for the clinical treatment. Material and methods: 71 cases with KCOT underwent decompression from August 2006 to December *** the patients were followed up for 6 months to 4 ***,X-ray examination were performed for evaluation of results. The paraffin-embeded tissue sections of KCOT epithelium befor and after decompression were used for pathology and immunohistochemical detection of Ki-67 and Bcl-2. Tissue enzyme digestion techniques was used for serially cultivation in vitro of KCOT *** cells were grown in keratinocyte-serum free *** biological charateristics of the cultivated kerationcytes were identified by phase microscopic observation. Results: 71 cases of KCOT after decompression,the sizes of cysts reduced gradually, bone regeneration was noticed on *** the cases gained a total effective rate of 91.55%,2 cases were recurrent. KCOT epithelial gradually lose its microscopic characteristics after ***-67 Li was reduced after *** expression of Bcl-2 in postoperative epithelium were significantly less than in preoperative epithelium. KCOT epithelium cells were polygon showed typical slabstone-like appearance. Keratinocytes could survive for 30-50 days after passing 2-4 generations. Conclusion: *** is a safe and effective method of KCOT treatment. *** KCOT could enhance the proliferation of epithelium cell,may be the part of the mechanism of decompression. *** epithelial cells could be serially cultured in vitro in K-S

关键词： keratocystic odontogenic tumor Decompression Immunohistochemistry Epithelial cells culture

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Identification of the involvement of LOXL4 in generation of keratocystic odontogenic tumors by RNA-Seq analysis

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International Journal of Oral Science 2014年第1期6卷 31-38页

作者： Wei-Peng Jiang Zi-Han Sima Hai-Cheng Wang Jian-Yun Zhang Li-Sha Sun Feng Chen Tie-Jun Li Department of Oral Pathology Peking University School and Hospital of Stomatology Central Laboratory Peking University School and Hospital of Stomatology

keratocystic odontogenic tumors （KCOT） are benign, locally aggressive intraosseous tumors of odontogenic origin. KCOT have a higher stromal microvessel density （MVD） than dentigerous cysts （DC） and normal oral mucosa. To identify genes in the stroma of KCOT involved in tumor development and progression, RNA sequencing （RNA-Seq） was performed using samples from KCOT and primary stromal fibroblasts isolated from gingival tissues. Seven candidate genes that possess a function potentially related to KCOT progression were selected and their expression levels were confirmed by quantitative PCR, immunohistochemistry and enzyme-linked immunosorbent assay. Expression of lysyl oxidase-like 4 （LOXL4）, the only candidate gene that encodes a secreted protein, was enhanced at both the mRNA and protein levels in KCOT stromal tissues and primary KCOT stromal fibroblasts compared to control tissues and primary fibroblasts （P〈0.05）. In vitro, high expression of LOXL4 could enhance proliferation and migration of the human umbilical vein endothelial cells （HUVECs）. There was a significant, positive correlation between LOXL4 protein expression and MVD in stroma of KCOT and control tissues （r=0.882）. These data suggest that abnormal expression of LOXL4 of KCOT may enhance angiogenesis in KCOT, which may help to promote the locally aggressive biological behavior of KCOT.

关键词： angiogenesis keratocystic odontogenic tumor lysyl oxidase-like 4 RNA-sequencing tumor stromal fibroblast

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维普期刊数据库

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Identification of Known and Novel PTCH Mutations in Both Syndromic and Non-syndromic keratocystic odontogenic tumors

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International Journal of Oral Science 2009年第1期1卷 34-38页

作者： Shuang Pan Li-li Xu Li-sha Sun Tie-jun Li Department of Oral Pathology Peking University School and Hospital of Storaatology Beijing China

Aim To clarify the role of PTCH in patients with NBCCS- related and non-sydromic keratocystic odontogenic tumors. Methodology Mutation analysis was undertaken in 8 sporadic and 4 NBCCS-associated KCOTs. Results Four novel and two known mutations were identifled in 2 sporadic and 3 syndromic cases, two of which being germline mutations （c.2179delT, c.2824delC） and 4 somatic mutations （c.3162dupG, c.1362-1374dup, c.1012 C〉T, c.403C〉T）. Conclusion Our findings suggest that defects of PTCH are associated with the pathogenesis of syndromic as well as a subset of non-syndromic KCOTs.

关键词： keratocystic odontogenic tumor mutation,nevoid basal cell carcinoma syndrome PTCH

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odontogenic Keratocyst tumor: A Case Report and Literature Review

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Open Journal of Stomatology 2016年第7期6卷 171-178页

作者： Akram Belmehdi Saliha Chbicheb Wafaa El Wady Department of Oral Surgery Dental Center of Treatment and Diagnosis (Ibn Sina Hospital) Rabat Morocco Oral Surgery Service Faculty of Dentistry of Rabat Mohammed V University Rabat Morocco

First described by Philipsen in 1956, the odontogenic keratocyst is characterized by a large squamous keratinization of its border, an aggressive growth and a high recurrent rate. It is now designated by the World Health Organization as a keratocystic odontogenic tumour (KOT). Clinically, the KOT is manifested by an asymptomatic growth. Radiographically, it appears as a well-defined uni-locular or multilocular osteolytic lesion. The diagnostic approach is based on a combined analysis of the medical history, the clinical appearance and the radiographic appearance. The diagnosis may be confirmed by the anatomical pathology report. Finally, treatment consists of surgical excision and follow up is characterized by a high rate of recurrence. The authors report a case of keratocystic odontogenic tumor of the upper jaw and review the various diagnoses, therapeutics and follow up aspects of this type of tumors.

关键词： keratocystic odontogenic tumor Benign tumor Surgery Maxilla

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牙源性角化囊肿恶变为鳞状细胞癌病例报告及文献回顾

牙源性角化囊肿恶变为鳞状细胞癌病例报告及文献回顾

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2020年全国口腔颌面-头颈肿瘤学术大会暨中华口腔医学会口腔颌面-头颈肿瘤专业委员会学术年会——创新超越、共赢未来

作者：蒋圣超李霁邓伟伟熊学鹏孙艳芳武汉大学口腔医院

研究目的:牙源性角化囊肿(odontogenic keratocyst,OKC)是一种颌骨内常见的囊肿。牙源性角化囊肿发生癌变的概率是非常小的,国内报道的发生率约为2.65%,国外报道的发生率在0.1%～1.8%左右。本文报道一例牙源性角化囊肿恶变为鳞状细胞癌... 详细信息

研究目的:牙源性角化囊肿(odontogenic keratocyst,OKC)是一种颌骨内常见的囊肿。牙源性角化囊肿发生癌变的概率是非常小的,国内报道的发生率约为2.65%,国外报道的发生率在0.1%～1.8%左右。本文报道一例牙源性角化囊肿恶变为鳞状细胞癌,并就其临床特点进行文献回顾。

关键词： malignant transformation odontogenic keratocyst keratocystic odontogenic tumor squamous cell carcinoma

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