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Effect of Cyclosporin a Eye Drop on keratoconjunctivitis sicca and Its Mechanism

Journal of Huazhong University of Science and Technology(Medical Sciences) 2005年第6期25卷 738-740页

作者：孙京华刘常明张煜昭王慧 Department of Ophthalmology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China

In this study, the effect of cyclosporin A （CsA） eye drop on keratoconjunctivitis sicca （KCS） and its mechanism were studied. The KCS models were established by injecting Pertussis vaccine, complete freund＇s adjuvant （CFA） and antigen of conjunctiva from isotype mice. Then the KCS models were treated with cyclosporin A eye drop. Changes in breaking-up time （BUT）, lacrimal secretion in 30 min and diversion in 24 h were measured. The percentage of beaker cells, the lymphocytic infiltration in conjunctiva were observed. The expression levels of Aquaporin-3 （AQP3） in conjunctiva epithelial cells, beaker cells and accessory lacrimal gland were immunohistochemically detected. The results showed that there were significant differences in BUT, the percentage of beaker cells, lacrimal secretion in 30 min, the lymphocytic infiltration and the expression of AQP3 between the experimental group and an control group. It was *** CsA eye drop exerts marked therapeutic effect on KCS by inhibiting T lymph cells, increasing the goblet cells and AQP3 expression in conjunctiva.

关键词： keratoconjunctivitis sicca cyclosporin A eye drop beaker cell aquaporin-3

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Acupuncture combined with pyonex for xerophthalmia

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World Journal of Acupuncture-Moxibustion 2016年第2期26卷 37-42页

作者：高辉赵晓东马国娟李焕丽刘怀栋河北省人民医院河北省医学情报研究所

Objective To compare the clinical efficacy of acupuncture therapy and acupuncture combined with pyonex in treatment of xerophthalmia. Methods Eighty-eight xerophthalmia patients were randomly divided into group A （periocular acupuncture） and group B （acupuncture combined with pyonex）. The treatment was conducted once a day, twelve days were one course of treatment, and two courses were needed in total. The changes of symptom score of eyes, Schirmer I test （SIT） and break-up time （BUT） of patients in the two groups before and after treatment were observed. Results The symptom score of eyes （8.36＋2.54 vs. 5.36_＋2.65）, SIT （5.82＋4.61 vs. 8.33＋4.24） and BUT （5.92＋2.03 vs. 6.78＋2.46） of patients in the two groups after treatment were improved when compared with those before treatment. The total effective rate of group B was superior to that of group A （86.3% vs. 63.6%）（all P〈0.05）. Conclusion The efficacy of acupuncture combined with pyonex in treatment of xerophthalmia is significant, which can effectively improve the symptoms of xerophthalmia, and is superior to simple periocular acupuncture in terms of SIT and BUT.

关键词： xerophthalmia keratoconjunctivitis sicca acupuncture pyonex intradermal needle

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