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Risk factors of type 2 diabetes in population of Jammu and Kashmir, India

The Journal of Biomedical Research 2013年第5期27卷 372-379页

作者： Ankit Mahajan Swarkar Sharma Manoj K.Dhar Rameshwar N.K.Bamezai School of Biotechnology University of Jammu National Centre of Applied Human Genetics School of Life Sciences Jawaharlal Nehru University School of Biology and Chemistry Shri Mata Vaishno Devi University

We sought to identify risk factors for type 2 diabetes （T2D） in Jammu and Kashmir populations, India. A total of 424 diabetic and 226 non-diabetic subjects from Jammu, and 161 diabetic and 100 non-diabetic subjects from Kashmir were screened for various parameters including fasting blood glucose level, 2 hour glucose level, urea, creatinine, triglycerides, total cholesterol, high-density lipoprotein cholesterol （HDL-C）, low-density lipoprotein cholesterol （LDL-C）, very low-density lipoprotein （VLDL-C）, uric acid, systolic and diastolic blood pressure lev- el. We found that subjects aged 40-49 years had the highest rate of diabetes, with family income playing not much of a role. kashmiri migrants or populations with rapid cultural, environmental, social or lifestyle change along with reduced physical activity, obesity and unhealthy lifestyle （smoking and alcohol consumption） were found to have higher rates of diabetes. High blood glucose, triglycerides and low HDL-C levels were found to be con- tributing to disease outcome. High blood pressure also contributed to a higher risk of developing T2D. Our study supports earlier reports confirming the contribution of comfortable life style, Western dietary habits and rapid life style change along with many other factors to the prevalence of diabetes. This may contribute to the epidemic proportion of diabetes in Jammu and Kashmir. Early diagnosis and routine screening for undiagnosed diabetes in obese subjects and subjects with parental diabetes history is expected to decrease the burden of chronic diabetic complications worldwide.

关键词： type 2 diabetes north India life style kashmiri migrants body mass index

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