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Pretreated Oenan the javanica extract increases anti-inflammatory cytokines, attenuates gliosis, and protects hippocampal neurons following transient global cerebral ischemia in gerbils

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Neural Regeneration Research 2019年第9期14卷 1536-1543页

作者： Joon Ha Park In Hye Kim Ji Hyeon Ahn YooHun Noh Sung-Su Kim Tae-Kyeong Lee Jae-Chul Lee Bich-Na Shin Tae Heung Sim Hyun Sam Lee Jeong Hwi Cho In Koo Hwang Il Jun Kang Jong Dai Kim Moo-Ho Won Department of Biomedical Science and Research Institute for Bioscience and Biotechnology Hallym UniversityChuncheonGangwonRepublic of Korea Famenity Company GwacheonGeyonggiRepublic of Korea Department of Neurobiology School of MedicineKangwon National UniversityChuncheonGangwonRepublic of Korea Danchunok Company ChuncheonGangwonRepublic of Korea Department of Histology College of Veterinary MedicineChonbuk National UniversityIksanJeollabuk.doRepublic of Korea Department of Anatomy and Cell Biology College of Veterinary Medicineand Research Institute for Veterinary ScienceSeoul National UniversitySeoulRepublic of Korea Department of Food Science and Nutrition Hallym UniversityChuncheonGangwonRepublic of Korea Division of Food Biotechnology School of BiotechnologyKangwon National UniversityChuncheonGangwonRepublic of Korea

Recently,we have reported that Oenanthe javanica extract(OJE)displays strong neuroprotective effect against ischemic damage after transient global cerebral ischemia.However,neuroprotective mechanisms of OJE have not been fully identified.Thus,this study investigated the neuroprotection of OJE in the hippocampal CA1 area and its anti-inflammatory activity in gerbils subjected to 5 minutes of transient global cerebral ischemia.We treated the animals by intragastrical injection of OJE(100 and 200 mg/kg)once daily for 1 week prior to transient global cerebral ischemia.Neuroprotection of OJE was observed by immunohistochemistry for neuronal nuclear antigen and histofluorescence staining for Fluoro-Jade B.Immunohistochemistry of glial fibrillary acidic protein and ionized calcium-binding adapter molecule 1 was done for astrocytosis and microgliosis,respectively.To investigate the neuroprotective mechanisms of OJE,we performed immunohistochemistry of tumor necrosis factor-alpha and interleukin-2 for pro-inflammatory function and interleukin-4 and interleukin-13 for anti-inflammatory function.When we treated the animals by intragastrical administration of 200 mg/kg of OJE,hippocampal CA1 pyramidal neurons were protected from transient global cerebral ischemia and cerebral ischemia-induced gliosis was inhibited in the ischemic hippocampal CA1 area.We also found that interleukin-4 and-13 immunoreactivities were significantly increased in pyramidal neurons of the ischemic CA1 area after OJE pretreatment,and the increased immunoreactivities were sustained in the CA1 pyramidal neurons after transient global cerebral ischemia.However,OJE pretreatment did not increase interleukin-2 and tumor necrosis factor-alpha immunoreactivities in the CA1 pyramidal neurons.Our findings suggest that pretreatment with OJE can protect neurons and attenuate gliosis from transient global cerebral ischemia via increasing expressions of interleukin-4 and-13.The experimental plan of this study was reviewed and approved by the Institutional Animal C

关键词： Oenanthe javanica extract transient global cerebral ischemia hippocampus ischemic damage cerebral ischemia neuroprotection glial activation pro-inflammatory cytokines anti-inflammatory cytokines inflammation neural regeneration

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Activity of Brucea javanica oil emulsion against gastric ulcers in rodents

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Asian Journal of Pharmaceutical Sciences 2018年第3期13卷 279-288页

作者： Qian Li Linglong Yang Linlin Fan Chen Liang Qiujv Wang Huimin Wen Jinwei Dai Xin Li Yuyang Zhang School of Life Science and Biopharmaceutics Shenyang Pharmaceutical University

The present study aims to investigate the gastroprotective effect of Brucea javanica oil emulsion(BJOE) in animals. Gastroprotective potential of BJOE was studied on absolute ethanol,aspirin, reserpine and restraint plus water immersion-induced gastric ulcers in mice as well as glacial acetic acid(GAA) and pyloric ligation(PL)-induced gastric ulcers in rats. Except for ulcer scores, total acidity as well as pepsin activity as for the PL-induced gastric ulcer model and ulcer incidence as for the GAA-induced gastric ulcer model were also determined. Histopathological evaluation as for aspirin, reserpine, PL-induced models was conducted. Results showed that BJOE significantly(P < 0.05) reduced ulcer index in the mouse and rat models in a dose-dependent manner. It had significant(P < 0.05) suppressive effect on total activity of gastric juice as well in PL-induced model. Histopathological examination for the stomach samples confirmed the findings in the aspirin, reserpine or PLinduced gastric lesion models, which showed relatively complete mucosa structure and less inflammation. It is concluded that BJOE could be effective on gastric ulcer in rodents and its gastroprotective activity might be related to antioxidant, anti-inflammatory ability and promote gastric mucus secreted. The results may provide beneficial basis for increasing BJOE's clinical indication in future.

关键词： Gastric ulcer Brucea javanica oil emulsion Gastric mucosa Ulcer scores Glacial acetic acid Pepsin activity

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Brucea javanica oil emulsion improves the effect of radiotherapy on esophageal cancer cells by inhibiting cyclin D1-CDK4/6 axis

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World Journal of Gastroenterology 2019年第20期25卷 2463-2472页

作者： Zhong-Hua Qiu Wei-Wei Zhang Hong-Hua Zhang Gui-Hua Jiao Department of Neurology Liangshan County People's HospitalJining272600Shandong ProvinceChina Department of Neurology Liangshan County People's HospitalJining272600Shandong ProvinceChina

BACKGROUND Esophageal cancer is one of the most common cancers around the world, and it has high incidence and mortality rates. The conventional therapy for esophageal cancer is radiotherapy, although its effect is highly limited by the resistance of esophageal cancer cells. Thus, strong radiosensitizers can be very crucial during radiotherapy against esophageal cancer. Brucea javanica oil emulsion (BJOE) is a widely used drug against various cancers, such as liver, colon, and ovarian cancer. However, its anti-cancer effect and mechanism and the use of BJOE as a radiosensitizer have not been explored in esophageal cancer. AIM To evaluate the anti-cancer effect and mechanism of BJOE and explore the potential use of BJOE as a radiosensitizer during radiotherapy. METHODS The inhibitory effect of BJOE and its enhancement function with radiation on cell viability were examined with the calculated half-maximal effective concentration and half-maximal lethal concentration. The influence of BJOE on cell migration and invasion were measured with EC109 and JAR cells by wound-healing and transwell assay. Clonogenesis and apoptotic rate, which was measured by Hoechst staining, were investigated to confirm its enhancement function with radiation. To investigate the molecular pathway underlying the effect of BJOE, the expressions of several apoptosis- and cycle-related proteins was detected by western blotting.cell lines more than normal cell lines, and it markedly reduced migration and invasion in esophageal cancer cells (EC109 and JAR). Moreover, it promoted cell apoptosis and enhanced the effect of radiotherapy against esophageal cancerous cells. In the viability test, the values of half-maximal effective concentration and half-maximal lethal concentration were reduced. Compared to the control, only around 1/5 colonies formed when using BJOE and radiation together in the clonogenic assay. The apoptotic rate in EC109 was obviously promoted when BJOE was added during radiotherapy. Our study suggests that the expression of the

关键词： Esophageal cancer Brucea javanica oil emulsion Radiosensitizer Apoptosis Cyclin D1-CDK4/6 axis

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圈养马来穿山甲(Manis javanica)在1年内连续产2胎

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林业科技通讯 2016年第5期 51-52页

作者：余经裕彭建军马晓华重庆师范大学生命科学学院重庆401331 攀枝花市捷茂中药材种植有限公司四川攀枝花617000

圈养马来穿山甲(Manis javanica)进行人工饲养繁殖研究,在圈养条件下的同一只马来穿山甲在1年内连续产2胎,对其进行了详细的记录,填补了马来穿山甲繁殖参数的空白。

关键词：马来穿山甲 Manis javanica 圈养人工繁殖

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TDZ诱导金钱豹茎段丛生芽途径的离体快速繁殖

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仲恺农业工程学院学报 2017年第3期30卷 12-17页

作者：梁韩枝邓莎吴永清胡秀许炳强赵华仲恺农业工程学院园艺园林学院广东广州510225 中国科学院华南植物园广东广州510650

为解决金钱豹(Campanumoea javanica Bl.)丛生芽离体快繁体系在增殖阶段存在可持续继代和可重复性较差的问题,以金钱豹成熟种子萌发后带芽的茎段为外植体,以MS为基本培养基,添加不同质量浓度的6-苄基腺嘌呤(6-benzyladenine,BA)和噻苯隆... 详细信息

为解决金钱豹(Campanumoea javanica Bl.)丛生芽离体快繁体系在增殖阶段存在可持续继代和可重复性较差的问题,以金钱豹成熟种子萌发后带芽的茎段为外植体,以MS为基本培养基,添加不同质量浓度的6-苄基腺嘌呤(6-benzyladenine,BA)和噻苯隆(Thidiazuron,TDZ)以优化增殖激素配方;分别采用直接生根和间接生根法以获得完整的植株.结果表明:0.5 mg/L BA与低浓度的TDZ(0.01~0.05 mg/L)配合可获得理想的丛生芽,且具有较高的增殖倍数与可持续继代数;最佳植物生长调节剂配方为0.5 mg/L BA+0.02 mg/L TDZ,第5次继代的芽增殖倍数达10.9,可继代次数为10次;直接生根法中诱导的生根率和生根系数分别为28.5%~30.5%和2.5~3.3;间接生根法中不同质量浓度IBA预处理诱导的生根率和生根系数分别为30%~100%和1~5.3,其中300 mg/L IBA溶液浸泡茎段末端15 min,生根率为100%,生根系数为5.3,移栽30 d后成活率为90%.由此表明,所建立的金钱豹丛生芽离体最优快速繁殖体系可持续继代10次,芽增殖倍数保持在10左右;间接生根法诱导生根的效果优于直接生根法,高质量浓度的IBA预处理15 min诱导生根效果最好.

关键词：金钱豹(Campanumoea javanica Bl.) 组织培养丛生芽诱导生根

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野生马来穿山甲被引入圈养后的应激对策和对新环境的适应

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林业科技通讯 2016年第3期 41-45页

作者：廖国宇彭建军余经裕姜福林马晓华重庆师范大学生命科学学院重庆401331 攀枝花市捷茂中药材种植有限公司四川攀枝花617000

在重庆师范大学穿山甲饲养繁殖研究基地对新引入圈养环境下的2只雄性马来穿山甲(Manis javanica)(一只为成体,一只为亚成体)进行了行为观察研究,分别在室内进行预观察与连续观察、在人工圈养环境中连续观察,观察期为1个月。从分析结果看... 详细信息

在重庆师范大学穿山甲饲养繁殖研究基地对新引入圈养环境下的2只雄性马来穿山甲(Manis javanica)(一只为成体,一只为亚成体)进行了行为观察研究,分别在室内进行预观察与连续观察、在人工圈养环境中连续观察,观察期为1个月。从分析结果看出,成年穿山甲的适应环境能力要优于亚成年穿山甲个体,而日常活动开始时间早晚主要由其生理钟调节支配,还可能与其他物种在其周边活动有一定相关性,但与所处小环境并无太大的关联。在圈养环境中,其休息行为比重加大,并且攀爬、游走、作窝行为比重也增大;在圈养环境中,两只穿山甲出现不同日常生理状况,观察到的数据及行为比例对成功人工驯化和饲养野生穿山甲提供一定的科学依据和方法。

关键词：马来穿山甲 Manis javanica 圈养行为应激对策新环境适应

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桂东常见几种绿化树种大苗育苗平衡施肥研究

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林业科技通讯 2016年第4期 3-7页

作者：陈翠湖张帅黄炜黄书养欧伟新梁聚文梧州市林业技术推广站广西梧州543002 梧州市林业发展有限公司

研究高密度(行间距0.5m×0.5m)种植下,杜英(Elaeocarpus decipiens Hemsl)、秋枫(Bischofla javanica)、小叶榄仁(Terminalia mantaly)、蓝花楹(Jacaranda mimosifoia)、海红豆(Adenantherpavonina Linn.)和盆架子(Alstonia scholaris)6个树种绿化大苗圃地土壤理化性质变化规律,探索适合各树种绿化大苗育苗的施肥配方,为绿化苗圃科学施肥提供理论依据。结果表明:(1)各树种在梧州市生长表现良好,年均胸径生长量均高于1cm,除海红豆外,其它树种树高年均生长量均高于1m。(2)6个树种对不同矿质元素需求比例不同。(3)6个树种育苗林地土壤物理性质差别大,其中,盆架子和秋枫林地土壤偏紧,蓝花楹林地土壤紧实,对于盆架子、秋枫与蓝花楹圃地,应加强松土或多施有机肥。

关键词：杜英 Elaeocarpus decipiens Hemsl 秋枫 Bischofla javanica 小叶榄仁 Terminalia mantaly 蓝花楹 Jacaranda mimosifoia 海红豆 Adenantherpavonina Linn. 盆架子 Alstonia scholaris 大苗绿化树种平衡施肥

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