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Immunization of mice with cells from juvenile worms of Schistosoma japonicum provides immunoprotection against schistosomiasis

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Science China(Life Sciences) 2007年第6期50卷 822-830页

作者： ZENG TieBing1,2, CAI LiTing1, ZENG QingRen1, YANG ShengHui1, YU Rong1, LI YanQin1, FANG HuiLong1, LI BenWen3 & ZHANG ShunKe1 1 Cell & Molecular Biological Experiment Center and Department of Parasitology, Xiangya School of Medicine, Central South Uni- versity, Changsha 410013, China 2 Institute of Pathogenic Biology, Medical College, Nanhua University, Hengyang 420001, China 3 Infectious Diseases Division, Washington University School of Medicine, Washington 63110, USA Cell & Molecular Biological Experiment Center Department of Parasitology Xiangya School of Medicine Central South University Changsha 410013 China Institute of Pathogenic Biology Medical College Nanhua University Hengyang 420001 China Infectious Diseases Division Washington University School of Medicine Washington 63110 USA

To validate the protective efficacy against schistosomiasis by immunization with cells from juvenile Schistosoma japonicum in a murine model; to analyze possible factors related to protection, in this study, two independent repeated vaccination trials were performed. After three subcutaneous vaccinations, in trial one, in the absence of adjuvant, primary juvenile worm cells (pJCs) from S. japonicum induced remarkable average reductions in worm burden (54.3%), liver eggs per gram (LEPG) load (59.8%) as well as egg granulomas size (66.5%) compared to PBS control group (Pjaponicum with 58.4% worm reduction; 68.1% LEPG reduction (Pjaponicum juvenile worms provided high immunoprotection, for which the physical character of immunogens, stage-specific parasite; the type of immune response induced might be responsible, suggesting that vaccination with whole cells from S. japonicum larvae is a promising approach to produce protective immunity against schistosomiasis.

关键词： Schistosoma japonicum, juvenile worm cell, cultured cell, immunoprotection, immune response

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