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Effect of ivabradine on hyperpolarization activated cation current in canine pulmonary vein sleeve cardiomyocytes with atrial fibrillation

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Journal of Geriatric Cardiology 2008年第1期5卷 39-42页

作者： Yang Li Yan Huang Zongbin Li Hao Wang Jianguo Song Yuqi Liu Lei Gao Shiwen Wang Institute of Geriatric Cardiology Chinese PLA General HospitalBeijing 100853china Institute ofCardiologythe First affilated HospitalXinjiang Medical UniversityUrumqi 830054china Institute of Geriatric CardiologyChinese PLA General HospitalBeijing 100853china Institute of Geriatric CardiologyChinese PLA General HospitalBeijing 100853china Institute ofCardiologythe First affilated HospitalXinjiang Medical UniversityUrumqi 830054china Institute of Geriatric CardiologyChinese PLA General HospitalBeijing 100853china Institute of Geriatric CardiologyChinese PLA General HospitalBeijing 100853china Institute of Geriatric CardiologyChinese PLA General HospitalBeijing 100853china

Objective To study the effect of ivabradine on hyperpolarization activated cation current in canine pulmonary vein(PY) sleeve cardiomyocytes with atrial *** Dissociation of PVs yielded single cardiomyocytes from a Landengorff column without or with pacemaker activity from long-term rapidly atrial pacing (RAP) *** current was measured with the whole-cell patch-clamp *** Compared with the control group,the rapidly atrial pacing canine PV cardiomyocytes had spontaneous diastolic depolarization and had larger If *** (Iva,1 μM),a selective inhibitor of the If current,markedly reduced If currents in the RAP from -2.66±0.4 pA/pF to -1.58±0.1 pA/pF at the test potential of-120 mV (P＜0.01,n=12).Inhibition effect of Iva of If current showed concentration-dependent range from 0.1 to 10.0μM,with IC50 of 2.2 μ M ( 1.8-2.9 μM,95% CL).Furthermore,V1/ of steady-state activated curve was shifted from -84.3±4.9 mV to -106.9±3.4 mV and k value of steady-state activated curve was changed from 12.1+2.6 mV to 9.9±3.4 mV by the application of.1.0 μM Iva ( P＜0.01,n=12).Conclusions Our study revealed that ivarbadine may significantly decrease If of rapidly atrial pacing pulmonary vein sleeve ceUs with atrial fibdllation.(J Geriatr Cardiol 2008;5:39-42)

关键词： ivarbadine hyperpolarization activated cation anine pulmonary vein sleeves atrial fibrillation

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