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islet organoid as a promising model for diabetes

Protein & Cell 2022年第4期13卷 239-257页

作者： Xiaofei Zhang Zhuo Ma Eli Song Tao Xu National Laboratory of Biomacromolecules CAS Center for Excellence in BiomacromoleculesInstitute of BiophysicsChinese Academy of SciencesBeijing 100101China Key Laboratory of Molecular Biophysics of the Ministry of Education College of Life Science and TechnologyHuazhong University of Science and TechnologyWuhan 430074China College of Life Sciences University of Chinese Academy of SciencesBeijing 100049China Guangzhou Regenerative Medicine and Health Guangdong Laboratory(Bioland Laboratory) Guangzhou 510005China

Studies on diabetes have long been hampered by a lack of authentic disease models that,ideally,should be unlimited and able to recapitulate the abnormalities involved in the development,structure,and function of human pancreatic islets under pathological *** cell-based islet organoids faithfully recapitulate islet development in vitro and provide large amounts of three-dimensional functional islet biomimetic materials with a morphological structure and cellular composition similar to those of native ***,islet organoids hold great promise for modeling islet development and function,deciphering the mechanisms underlying the onset of diabetes,providing an in vitro human organ model for infection of viruses such as SARS-CoV-2,and contributing to drug screening and autologous islet ***,the currently established islet organoids are generally immature compared with native islets,and further efforts should be made to improve the heterogeneity and functionality of islet organoids,making it an authentic and informative disease model for ***,we review the advances and challenges in the generation of islet organoids,focusing on human pluripotent stem cell-derived islet organoids,and the potential applications of islet organoids as disease models and regenerative therapies for diabetes.

关键词： islet organoid diabetes pluripotent/adult stem cell pancreaticβcell disease model

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