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The establishment of pancreatic islet isolation in India-an update on human pancreatic islet transplantation

Life Research 2022年第4期5卷 12-18页

作者： Nithyakalyani Mohan Srividhya Raghavan Anusha Sunder Anil Vaidya Nivash Chandrasekaran Senthil Muthuraman Dinesh Babu Karthik Mathivanan Elan Krishnan Balamurugan Appakalai Transplant and Research Apollo HospitalsChennaiIndia Molecular Biology Research Siruseri Biotech Park for WomenIndia Apollo Hospital and Research Foundation India Transplant and General Surgery American Samoa Department of Anesthesiology Velammal Medical College Hospital&Research lnstituteIndia Surgical Gastroenterology and transplantation Velammal Medical College Hospital&Research lnstituteIndia Transplant science and ICU MGM Health CareIndia Institute of liver and multiorgan transplant MGM Health CareIndia Liver Transplant Kauvery HospitalsIndia Clinical islet cell Laboratory Cardiovascular Innovation InstituteAmerican Samoa

Background:Diabetes is a widespread disease with increasing *** of islets of Langerhans is a viable treatment for a selected group of patients with repeated hypoglycemic episodes in type 1 *** countries where islet transplantation has not been explored suffer from insufficient knowledge concerning key elements of the isolation *** and organ procurement parameters impact human islet yield,although for research purposes,islet yield may be secondary in importance to islet *** paper will analyze the feasibility of research-only human islet isolation and signify parameters underlying a successful yield in the Indian *** eventually can make islet transplantation a clinical reality in ***:After receiving the consent for procuring brain-dead pancreas from the first-degree of relatives,samples were collected and transported in a transportation buffer at 4℃.The procedure consists of a mechanically enhanced enzymatic digestion of the pancreas,after which it was taken for purification using Ficoll method,followed by islet quality ***:Through 15 isolations done over a span of approximately 2 years during the COVID pandemic in India,we confirm that ischemic time and glycated hemoglobin,each have a negative impact on isolation purity and ***,extending cold ischemic tim beyond the typical clinical isolation cutoff of 12 hours(to≥18 h)had a huge impact on islet function and *** had a negative correlation with islet yield;however other biological parameters(specifically body mass index)and isolation variables appear to make a significant contribution to the heterogeneity of human islet *** current work demonstrates the feasibility of extending acceptable cold ischemic time for research-focused human islet isolation and highlights the biological variation in isolation of human islets from donors with and without ***:India requires establishment of an islet transpl

关键词： human islets islet cell transplantation type 1 diabetes mellitus chronic pancreatitis cold ischemia time glycated hemoglobin allo and auto-transplantation

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