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Adiponectin:mechanisms and new therapeutic approaches for restoring diabetic heart sensitivity to ischemic post-conditioning

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Frontiers of Medicine 2013年第3期7卷 301-305页

作者： Tingting Wang Shanglong Yao Zhengyuan Xia Michael G.Irwin Department of Anesthesiology and Critical Care Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Anesthesiology The University of Hong KongHong Kong SARChina

Systemic inflammatory response following myocardial ischemia-reperfusion injury(IRI)to a specific organ may cause *** post-conditioning(IpostC)has emerged as a promising method for myocardial protection against IRI both in experimental and in clinical *** of endogenous nitric oxide(NO)is one of the major mechanisms by which IpostC confers ***,the sensitivity of the diabetic heart to IpostC is impaired and the underlying mechanism is ***(APN)is an adipocyte-derived plasma protein with anti-diabetic and anti-inflammatory *** levels of APN are decreased in obese subjects and in patients with type 2 *** supplementation has been shown to increase NO production and attenuate myocardial IRI in normal(non-diabetic)***,the effect of APN on myocardial injury in diabetic subjects,especially its potential in restoring the sensitivity of the diabetic heart to IpostC has not been *** the current paper,we discussed the possible reasons why the myocardium of diabetic subjects loses sensitivity to IpostC and also highlighted the potential effectiveness and mechanism of APN in restoring IpostC cardioprotection in *** review proposes to conduct studies that may facilitate the development of novel and optimal therapies to enhance cardioprotection in patients with severe diseases such as diabetes.

关键词： adiponectin ischemic post-conditioning ischemia reperfusion injury diabetes

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