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Ischemic preconditioning protects post-ischemic renal function in anesthetized dogs:role of adenosine and adenine nucleotides

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Acta Pharmacologica Sinica 2005年第7期26卷 851-859页

作者： ShojiKIMURA AkiraNISHIYAMA MatluburRAHMAN YouichiABE Kagawa 761-0793 Japan Department of Pharmacology Kagawa Medical University 1750-1 Ikenobe Kagawa 761-0793 Japan Department of Pharmacology Kagawa Medical University 1750-1 Ikenobe Kagawa 761-0793 Japan Department of Pharmacology Kagawa Medical University 1750-1 Ikenobe Kagawa 761-0793 Japan Department of Pharmacology Kagawa Medical University 1750-1 Ikenobe

Aim:To investigate the effects of renal ischemic preconditioning（IPC）on bothrenal hemodynamics and the renal interstitial concentrations of adenosine andadenine nucleotides induced by ischemia-reperfusion ***:Renalhemodynamics responses to ischemia-reperfusion injury in mongrel dog modelswere determined with or without multiple brief renal ischemic preconditioningtreatments,as well as the adenosine A1receptor antagonist（KW-3902）,*** renal interstitial concentrations of adenosine and adenine nucle-otides in response to ischemia-reperfusion injury,either following 1-3 cycles ofIPC or not,were measured simultaneously using microdialysis ***:One 10-min IPC,adenosine A1receptor antagonist（KW-3902）also shortened the recovery time of renal blood flow（RBF）and urine flow（UF）,as well as mean blood pressure（BP）.Advanced renal IPC attenuated theincrement of adenosine and adenine nucleotides,as well as recovery time duringthe 60-rain reperfusion which followed the 60-min renal *** of theserecovery times were dependent on the cycles of 10-min *** renal interstitialconcentrations of adenosine and adenine nucleotides increased and decreasedduring renal ischemia and reperfusion,***:A significantrelativity in dog models exists between the cycles of 10-min renal IPC and therecovery time of BP,UF,and RBF during the 60-min renal reperfusion following60-min renal ischemia,*** IPC can protect against ischemia-reperfusion injury and the predominant effect of endogenous adenosine inducedby prolonged renal ischemia;renal adenosine A1receptor activation during therenal ischemia-reperfusion injury is detrimental to renal function.

关键词： microdialysis ischemia preconditioning reperfusion injury kidney adenosine adenosine A1 receptor

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