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Inflammation and apoptosis accelerate progression to irreversible atrophy in denervated intrinsic muscles of the hand compared with biceps: proteomic analysis of a rat model of obstetric brachial plexus palsy

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Neural Regeneration Research 2020年第7期15卷 1326-1332页

作者： Xiao-Heng Yu Ji-Xin Wu Liang Chen Yu-Dong Gu Department of Hand Surgery Huashan Hospital and Institutes of Biomedical SciencesFudan UniversityShanghaiChina Shanghai Key Laboratory of Peripheral Nerve and Microsurgery ShanghaiChina

In treating patients with obstetric brachial plexus palsy,we noticed that denervated intrinsic muscles of the hand become irreversibly atrophic at a faster than denervated *** a rat model of obstetric brachial plexus palsy,denervated intrinsic musculature of the forepaw entered the irreversible atrophy far earlier than denervated *** this study,isobaric tags for relative and absolute quantitation were examined in the intrinsic musculature of forepaw and biceps on denervated and normal sides at 3 and 5 weeks to identify dysregulated *** of pathways mapped by those proteins was analyzed by Kyoto Encyclopedia of Genes and Genomes *** 3 weeks,119 dysregulated proteins in denervated intrinsic musculature of the forepaw were mapped to nine pathways for muscle regulation,while 67 dysregulated proteins were mapped to three such pathways at 5 *** 3 weeks,27 upregulated proteins were mapped to five pathways involving inflammation and apoptosis,while two upregulated proteins were mapped to one such pathway at 5 *** 3 and 5 weeks,53 proteins from pathways involving regrowth and differentiation were *** 3 weeks,64 dysregulated proteins in denervated biceps were mapped to five pathways involving muscle regulation,while,five dysregulated proteins were mapped to three such pathways at 5 *** protein mapped to inflammation and apoptotic pathways was upregulated from one pathway at 3 weeks,while three proteins were downregulated from two other pathways at 5 *** proteins mapped to regrowth and differentiation pathways were upregulated from three pathways at 3 weeks,while two proteins were downregulated in another pathway at 5 *** results implicated inflammation and apoptosis as critical factors aggravating atrophy of denervated intrinsic muscles of the hand during obstetric brachial plexus *** experimental procedures and protocols were approved by the Experimental Animal Ethics Committee of Fudan Univ

关键词： apoptosis biceps denervation inflammation intrinsic muscles of the hand irreversible muscle atrophy isobaric tags for relative and absolute quantitation nerve regeneration proteomic rat models reversible muscle atrophy

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