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A biotechnological perspective on the application of iron oxide nanoparticles

Nano Research 2016年第8期9卷 2203-2225页

作者： Farnaz Assa Hoda Jafarizadeh-Malmiri Hossein Ajamein Navideh Anarjan Hamideh Vaghari Zahra Sayyar Aydin Berenjian Faculty of Chemical Engineering Sahand University of Technology Tabriz *** Iran Department of Chemical Engineering Ilkhchi Branch Islamic Azad University Ilkhchi *** Iran Department of Chemical Engineering Tabriz Branch Islamic Azad University Tabriz *** Iran School of Engineering Faculty of Science and Engineering University of Waikato Hamilton 3240 New Zealand

In recent decades, magnetic iron nanoparticles （NPs） have attracted much attention due to properties such as superparamagnetism, high surface area, large surface-to-volume ratio, and easy separation under external magnetic fields. Therefore, magnetic iron oxides have potential for use in numerous applications, including magnetic resonance imaging contrast enhancement, tissue repair, immunoassay, detoxification of biological fluids, drug delivery, hyperthermia, and cell separation. This review provides an updated and integrated focus on the fabrication and characterization of suitable magnetic iron NPs for biotechnological applications. The possible perspective and some challenges in the further development of these NPs are also discussed.

关键词： iron oxide nanoparticle superparamagnetic biotechnology surface modification

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Magnetic iron oxide nanoparticles accelerate osteogenic differentiation of mesenchymal stem cells via modulation of long noncoding RNA INZEB2

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Nano Research 2017年第2期10卷 626-642页

作者： Qiwei Wang Bo Chen Fang Ma Shikang Lin Meng Cao Yan Li Ning Gu State Key Laboratory ofBioelectronics Jiangsu Key Laboratory for Biomaterials and Devices School of Biological Sciences & Medical Engineering Southeast University Nanjing 210096 China Collaborative Innovation Center of Suzhou Nano Science and Technology Suzhou 215123 China Key Laboratory of Developmental Genes and Human Diseases in Ministry of Education Institute of Life Sciences Southeast University Nanjing 210096 China SignalwayAntibody LLC College Park MD 20740 USA

Nanomaterials are increasingly used for biomedical applications; thus, it is important to understand their biological effects. Previous studies suggested that magnetic iron oxide nanoparticles （IONPs） have tissue-repairing effects. In the present study, we explored cellular effects of IONPs in mesenchymal stem cells （MSCs） and identified the underlying molecular mechanisms. The results showed that our as-prepared IONPs were structurally stable in MSCs and promoted osteogenic differentiation of MSCs as whole particles. Moreover, at the molecular level, we compared the gene expression of MSCs with or without IONP exposure and showed that IONPs upregulated long noncoding RNA INZEB2, which is indispensable for maintaining osteogenesis by MSCs. Furthermore, overexpression of INZEB2 downregulated ZEB2, a factor necessary to repress BMP/Smad- dependent osteogenic transcription. We also demonstrated that the essential role of INZEB2 in osteogenic differentiation was ZEB2-dependent. In summary, we elucidated the molecular basis of IONPs＇ effects on MSCs; these findings may serve as a meaningful theoretical foundation for applications of stem cells to regenerative medicine.

关键词： iron oxide nanoparticle mesenchymal stem cell osteogenic differentiation long noncoding RNA magnetogenetics nano-magnetic bioeffects

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Facile synthesis of magnetic iron oxide nanoparticles and their characterization

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Frontiers of Materials Science 2014年第2期8卷 193-198页

作者： Sushilkumar A. JADHAV Suresh V. PATIL Department of Chemistry and NIS Center University of Torino 10125 Torino Italy Department of Chemistry K.B.P. College Pandharpur affiliated to Solapur University Solapur (MH) India

Magnetic iron oxide nanoparticles are synthesized by suitable modification of the standard synthetic procedure without use of inert atmosphere and at room temperature. The facile synthesis procedure can be easily scaled up and is of important from industrial point of view for the commercial large scale production of magnetic iron oxide nanoparticles. The synthesized nanoparticles were characterized by thermal, dynamic light scattering, scanning electron microscopy and transmission electron microscopy analyses.

关键词： iron oxide iron oxide nanoparticle co-precipitation-

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Combination therapy using microwave ablation and d-mannose-chelated iron oxide nanoparticles inhibits hepatocellular carcinoma progression

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Acta Pharmaceutica Sinica B 2022年第9期12卷 3475-3485页

作者： Rui Cui Luo Wang Dongyun Zhang Kun Zhang Jianping Dou Linan Dong Yixuan Zhang Jiapeng Wu Longfei Tan Jie Yu Ping Liang Department of Interventional Ultrasound PLA General HospitalBeijing 100853China Department of Medical Ultrasonics the Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhou 510655China Laboratory of Controllable Preparation and App Department of Medical Ultrasound Shanghai Tenth People's HospitalTongji University School of MedicineShanghai 200072China Ultrasound Research and Education Institute Tongji University School of MedicineShanghai 200072China Laboratory of Controllable Preparation and Application of Nanomaterials Key Laboratory of CryogenicsTechnical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China

Despite being a common therapy for hepatocellular carcinoma(HCC),insufficient thermal ablation can leave behind tumor residues that can cause *** is believed to augment M2 inflammatory macrophages that usually play a pro-tumorigenic *** address this problem,we designed D-mannose-chelated iron oxide nanoparticles(man-IONPs) to polarize M2-like macrophages into the antitumor Ml *** vitro and in vivo experiments demonstrated that man-IONPs specifically targeted M2-like macrophages and accumulated in peri-ablation zones after macrophage infiltration was augmented under insufficient microwave ablation(MWA).The nanoparticles simultaneously induced polarization of pro-tumorigenic M2 macrophages into antitumor M1 phenotypes,enabling the transformation of the immunosuppressive microenvironment into an immunoactivating ***-MWA macrophage polarization exerted robust inhibitory effects on HCC progression in a well-established orthotopic liver cancer mouse ***,combining thermal ablation with man-IONPs can salvage residual tumors after insufficient *** results have strong potential for clinical translation.

关键词： Microwave ablation Hepatocellular carcinoma iron oxide nanoparticle Macrophage polarization Targeted therapy

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The effect of neighbor distance of magnetic nanoparticle clusters on magnetic resonance relaxation properties

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Science Bulletin 2016年第13期61卷 1023-1030页

作者： Dan Wang Bingbing Lin Taipeng Shen Jun Wu Chunchao Xia Bin Song Hua Ai National Engineering Research Center for Biomaterials Sichuan University Department of Radiology West China Hospital Sichuan University

Superparamagnetic iron oxide （SPIO） nanoparticle clusters are one unique form which can enhance magnetic relaxivity and improve the magnetic resonance imaging contrast at the same iron concentration, comparing to single SPIO nanoparticles. Controlling of cluster size and other structural parameters have drawn great interests in this field to further improve their magnetic properties. In this study, we investigated how the interparticle distance （also known as neighbor distance） of SP10 nanocrystals within clusters affect their magnetic relaxation behaviors. To adjust the neighbor distance, different amount of cholesterol （CHO） was chosen as model spacers embedded into SPIO nanocluster systems with the help of amphiphilic diblock copolymer poly（ethylene glyco）-polyester. Small- angle X-ray scattering was applied to quantify the neighbor distance of SPIO clusters. The results demonstrated that the averaged SPIO nanocrystal neighbor distance of nan- oclusters increased with higher amount of added CHO. Moreover, these SPIO nanocrystal clusters had the promi- nent magnetic relaxation properties. Simultaneously, con- trolling of SPIO nanocrystal neighbor distance can regulate the saturation magnetization （Ms） and magnetic resonance （MR） T2 relaxation of the aggregation, and ultimately obtain better MR contrast effects with decreased neighbor distance.

关键词： iron oxide nanoparticle Clusters Neighbor distance Magnetic properties T2relaxation

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iron and Oxygen Chemistry in Nature’s Nanocage Proteins,the Ferritins

Iron and Oxygen Chemistry in Nature’s Nanocage Proteins,the...

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中国化学会第26届学术年会化学生物分会场

作者： Elizabeth C. Theil Takehiko Tosha CHORI Children’s Hospital Oakland Research Institute and the Dept. of Nutr. ＆ Tox. University of California-Berkeley CHORI Children’s Hospital Oakland Research Institute and the Dept. of Nutr. ＆ Tox. University of California-Berkeley

Diferric oxo/hydroxo mineral precursors are synthesized from Fe（II） and dioxygen substrates at multiple, Fe（II）/O2 oxidoreductase sites in the ferritin protein nanocage. Hydrated ferric oxide minerals form in the ferritin protein nanocage by catalytic coupling reactions, vectorial transport through the protein to the nanocage cavity, and hydrolysis in the cavity;mineral size is up to 4500 Fe, 9000 O and 4500 H atoms [ferrihydrate: Fe2O3.H2O/ FeOOH)] and variable phosphate. The iron biominerals have two biological functions: 1. concentrating iron for the biosynthesis of Fe-protein centers, a critical function based on the lethality of gene deletion, and 2. minimizing free radical chemistry and inflammation, by moving Fe （II） and O2 from the cell cytoplasm to the mineral. We will describe our studies on identifying amino acids and their function at the ferritin Fe（II）/O2 oxidoreductase catalytic site, where the first detectable reaction product, diferric peroxo, is also formed by di-iron cofactors and dioxygen in oxygenases e.g., methane monooxygenase and ribonucleotide reductase. In addition, we will discuss possible mechanisms for recovering Fe（II） from the ferritin nanocage, through gated protein pores, using reductants （NADH/FMNH）, chelators and peptides that bind selectively to ferritin and alter pore folding/unfolding in analogy to peptide-regulated ion channel protein pores. The results increase understanding of protein catalysis, protein pores, regulated protein folding/unfolding, human iron absorption from ferritin in natural foods （soy, lentil, etc）, medical management of transfusional iron overload or inflammation, and biomineralization. Support: NIH: ECT, XSL, TT), Cooley’s Anemia Foundation （XSL）, JSPS （Japan Society for the Promotion of Science）（TT）.

关键词： Ferritin iron oxide nanoparticle Fe(II)/O2 oxidoreductase protein pore gating bioinorganic chemistry

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