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iron metabolism in non-alcoholic fatty liver disease: A promising therapeutic target

Liver Research 2022年第4期6卷 203-213页

作者： Hanqing Chen Department of Gastroenterology and Hepatology Guangzhou Digestive Disease CenterGuangzhou Key Laboratory of Digestive DiseasesGuangzhou First People's HospitalSchool of MedicineSouth China University of TechnologyGuangzhouGuangdongChina

Non-alcoholic fatty liver disease(NAFLD)has become the most common cause of chronic liver disease worldwide,and is closely associated with the increased risk of the prevalence of obesity and *** begins with the presence of>5%excessive lipid accumulation in the liver,and potentially de-velops into non-alcoholic steatohepatitis,fibrosis,cirrhosis and hepatocellular ***,insight into the pathogenesis of NAFLD is of key importance to its effective *** is an essential element in the life of all mammalian ***,the free iron deposition is positively associated with histological severity in NAFLD patients due to the production of reactive oxygen species via the Fenton ***,several iron metabolism-targeted therapies,such as phlebotomy,iron chela-tors,*** ferroptosis,have shown their potential as a therapeutic option in the treatment of NAFLD and as a clinical strategy to intervene in the progression of ***,we review the recent overall evidence on iron metabolism and provide the mechanism of hepatic iron overload-induced liver pathologies and the recent advances in iron metabolism-targeted therapeutics in the treatment of NAFLD.

关键词： Non-alcoholic fatty liver disease(NAFLD) Hepatic iron overload Phlebotomy iron chelators Nanomedicine Ferroptosis

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The soil fungi producing siderophores of ***,Tawang,La Trinidad,Benguet

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Studies in Fungi 2019年第1期4卷 1-13页

作者： Hipol RM Baldelomar JA Bolinget KC Solis AFF Department of Biology College of ScienceUniversity of the Philippines Baguio

Siderophores,being iron-chelators,have received much attention in environmental research,medicine,and biotechnology because of their high affinity and specificity to a wide range of *** study aimed to investigate siderophore production of culturable soil fungi from ***,Tawang,La Trinidad,Benguet and to determine their chemical *** production was detected and quantified using Chrome Azurol Sulphonate assay while the siderophore characterization was through FeCl_(3),Csáky’s and Arnow’s *** was found that 11 out of 20 pure cultures,which showed positive CAS assay results,produce *** primers were used in PCR amplification for the molecular identification of the top-four *** on BLASTn analyses of their sequences,the isolates were found to be most homologous to species of Talaromyces,Byssochlamys,Paecilomyces,and *** identified species were subjected to phylogenetic analysis using MEGA 7 to the show evolutionary history and relationship among the fungal species.

关键词： CAS assay hydroxamates iron chelators

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