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Chronic exposure to excess iron promotes EMT and cancer via p53 loss in pancreatic cancer

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Asian Journal of Pharmaceutical Sciences 2020年第2期15卷 237-251页

作者： Yangzom D.Bhutia Jiro Ogura Paul J.Grippo Carolina Torres Toshihiro Sato Mitchell Wachtel Sabarish Ramachandran Ellappan Babu Sathish Sivaprakasam Devaraja Rajasekaran Bradley Schniers Nhu On Logan Smoot Muthusamy Thangaraju Jaya P.Gnana-Prakasam Vadivel Ganapathy Department of Cell Biology and Biochemistry Texas Tech University Health Sciences CenterLubbockTX 79430USA Department of Pharmaceutical Sciences Tohoku University Hospital1-1 Seiryo-machiAoba-kuSendaiMiyagi 980-8574Japan Department of Medicine University of Illinois at ChicagoChicagoIL 60607USA Department of Surgical Pathology Texas Tech University Health Sciences CenterLubbockTX 79430USA Department of Biological Sciences Texas Tech UniversityLubbockTX 79410USA Department of Chemistry and Biochemistry Texas Tech UniversityLubbockTX 79410USA Department of Biochemistry and Molecular Biology Augusta UniversityAugustaGA 30912USA Department of Ophthalmology St.Louis UniversitySt.LouisMO 63104USA

Based on the evidence that hemochromatosis, an iron-overload disease, drives hepatocellular carcinoma, we hypothesized that chronic exposure to excess iron, either due to genetic or environmental causes, predisposes an individual to cancer. Using pancreatic cancer as our primary focus, we employed cell culture studies to interrogate the connection between excess iron and cancer, and combined in vitro and in vivo studies to explore the connection further. Ferric ammonium citrate was used as an exogenous iron source. Chronic exposure to excess iron induced epithelial-mesenchymal transition(EMT) in normal and cancer cell lines, loss of p53, and suppression of p53 transcriptional activity evidenced from decreased expression of p53 target genes(p21, cyclin D1, Bax, SLC7A11). To further extrapolate our cell culture data, we generated EL-KrasG12D( EL-Kras) mouse(pancreatic neoplastic mouse model) expressing Hfe+/+ and Hfe-/- genetic background. p53 target gene expression decreased in EL-Kras/Hfe-/- mouse pancreas compared to EL-Kras/Hfe+/+ mouse pancreas. Interestingly, the incidence of acinar-to-ductal metaplasia and cystic pancreatic neoplasms(CPN) decreased in EL-Kras/Hfe-/- mice, but the CPNs that did develop were larger in these mice than in EL-Kras/Hfe+/+ mice. In conclusion, these in vitro and in vivo studies support a potential role for chronic exposure to excess iron as a promoter of more aggressive disease via p53 loss and SLC7A11 upregulation within pancreatic epithelial cells.

关键词： SLC7A11 p53 iron Heme Epithelial-mesenchymal transition

Mechanism of improved magnetizing roasting of siderite–hematite iron ore using a synergistic CO–H2 mixture

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Journal of iron and Steel Research(International) 2020年第1期27卷 12-21页

作者： Qiang Zhao Ji-lai Xue Wen Chen School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China Changsha Research Institute of Mining and Metallurgy Co. Ltd.Changsha 410083HunanChina

A fluidized-bed magnetizing roasting-magnetic separation process was selected to treat this type of material.Phase transformations and microstructural changes in the product resulting from magnetizing roasting under different reducing gases(CO,H2,CO+H2)were clarified by vibrating sample magnetometry,X-ray diffraction,scanning electron microscopy,and energy-dispersive X-ray spectroscopy.The results indicated that the conversion ratio and saturation magnetization of samples roasted in a mixed gas of CO and H2 were higher than those of samples produced under CO or H2 alone.This indicated that synergy of the combined CO and H2 gas had a positive effect on the fluidized-bed magnetizing roasting process.The mechanism and kinetics of the improved magnetizing roasting of a siderite-hematite iron ore mixture under this synergistic CO-H2 system were investigated under isothermal conditions.The results indicated that the apparent activation energies of the reactions of the iron oxides decreased from 37.7 and 17.9 to 15.9 kJ/moI when the roasting atmosphere was changed from pure H2 or CO to a gas mixture of CO and H2,respectively.The mixed CO-H2 gas promoted the conversion ratio of hematite and siderite to magnetite,thereby improving the conversion ratio in the fluidized-bed magnetizing roasting process.

关键词： Siderite Hematite Mixed iron ore Fluidized-bed magnetizing roasting Kinetics Magnetite

Simultaneous measurement of aqueous redox-sensitive elements and their species across the soil-water interface

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Journal of Environmental Sciences 2021年第4期33卷 1-10页

作者： Zhao-Feng Yuan Williamson Gustave Raju Sekar Jonathan Bridge Jia-Yue Wang Wei-Jia Feng Bin Guo Zheng Chen Department of Health and Environmental Sciences Xi’an Jiaotong-Liverpool UniversityJiangsu 215123China Department of Environmental Science University of LiverpoolLiverpool L697ZXUK Department of Plant Science Tarim UniversityXinjiang 843300China Chemistry Environmental&Life SciencesUniversity of The BahamasNassauBahamas Department of Biological Sciences Xi’an Jiaotong-Liverpool UniversityJiangsu 215123China Department of Natural and Built Environment Sheffield Hallam UniversitySheffield S11WBUK Institute of Environment ResourceSoil and FertilizerZhejiang Academy of Agricultural SciencesZhejiang 310021China

The redox-sensitive elements,such as iron,manganese,sulfur,phosphorus,and arsenic,shift their speciation every millimeter(mm)across the soil-water interface in the flooded soil environments.Monitoring of element speciation at this high-resolution(HR)within the SWI is still difficult.The key challenge lies in obtaining sufficient porewater samples at specific locations along the soil gradient for downstream analysis.Here with an optimized inductively coupled plasma mass spectrometry(ICP-MS)method and a HR porewater sampler,we demonstrate mm-scale element profiles mapping across the SWI in paddy soils.Highconcentrations of iron and manganese(>10 mg/L)were measured by ICP-MS in an extended dynamic range mode to avoid signal overflow.The iron profile along the SWI generated by the ICP-MS method showed no significant difference(piron,manganese,and arsenic,phosphorus,sulfur species(relative standard deviation<8%).The technique developed in this study will significantly promote the measurement throughput in limited samples(e.g.100μL)collected by HR samplers,which would greatly facilitate redox-sensitive elements biogeochemical cycling in saturated soils.

关键词： Porewater Soil-water interface Arsenic iron Sulfur Species

Separation and recovery of iron and scandium from acid leaching solution of red mud using D201 resin

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Journal of Rare Earths 2020年第12期38卷 1322-1329页

作者： Xuekai Zhang Kanggen Zhou Yehuizi Wu Qingyuan Lei Changhong Peng Wei Chen School of Metallurgy and Environment Central South UniversityChangsha 410083China

Red mud is a byproduct of alumina refining of bauxite ores,and is a significant source for extracting scandium.However,a large amount of iron in red mud makes it difficult to recover scandium because Fe(III) and Sc(Ⅲ) have similar physicochemical properties.In this study,a new method was developed for selective separation of iron and scandium in acid leachate of red mud using D201 resin.Theoretical calculations indicate that the ferric species mainly exists as FeCl3 or FeCl4-at chloride concentration above 6.65 mol/L,while scandium still exists as SCl2+,making it possible to selectively separate iron fro m scandium through anion resin adso rption.The factors affecting the adso rption of iron and scandium such as chloride conce ntratio n,resin dosage,adso rption time,and temperature were evaluated in batch experiments,The Langmuir model was successfully applied to both iron and scandium adsorption,and the maximum adsorption capacities of iron and scandium are 147.06 and 0.95 mg/g,respectively,indicating a significant difference between iron and scandium.Raman analysis further demonstrates that the iron is adsorbed onto D201 resin as FeCl4 anion.

关键词： Red mud Resource recovery iron Scandium Ion exchange Rare earths

Removal and recovery of toxic nanosized Cerium Oxide using eco-friendly iron Oxide Nanoparticles

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Frontiers of Environmental Science & Engineering 2020年第1期14卷 175-184页

作者： Kanha Gupta Nitin Khandelwal Gopala Krishna Darbha Department of Chemical Sciences USER KolkataMohanpurWest BengalPincode 741246India Environmental Nanoscience Laboratory Department of Earth SciencesUSER KolkataMohanpurWest BengalPincode 741246India Center for Climate&Environmental Studies USER KolkataMohanpurWest BengalPincode 741246India

Increasing applications of metal oxide nanoparticles and their release in the natural environment is a serious concern due to their toxic nature.Therefore,it is essential to have eco-friendly solutions for the remediation of toxic metal oxides in an aqueous environment.In the present study,eco-friendly iron Oxide Nanoparticles(IONPs)are synthesized using solvothermal technique and successfully characterized using scanning and transmission electron microscopy(SEM and TEM respectively)and powder X-Ray diffraction(PXRD).These IONPs were further utilized for the remediation of toxic metal oxide nanoparticle,i.e.,Ce02.Sorption experiments were also performed in complex aqueous solutions and real water samples to check its applicability in the natural environment.Reusability study was performed to show cost-effectiveness.Results show that these 200 nm-sized spherical IONPs,as revealed by SEM and TEM analysis,were magnetite(Fe3O4)and contained short-range crystallinity as confirmed from XRD spectra.Sorption experiments show that the composite follows the pseudosecond-order kinetic model.Further k>0.99 for Langmuir sorption isotherm suggests chemisorption as probable removal mechanism with monolayer sorption of Ce02 NPs on IONP.More than 80%recovery of adsorbed Ce02 NPs through ultrasonication and magnetic separation of reaction precipitate confirms reusability of IONPs.Obtained removal%of Ce02 in various synthetic and real water samples was>90%signifying that IONPs are candidate adsorbent for the removal and recovery of toxic metal oxide nanoparticles from contaminated environmental water samples.

关键词： Adsorption toxic metal oxide remediation eco-friendly IONP iron oxide CeO2 removal

Preparing high-purity iron by direct reduction?smelting separation of ultra-high-grade iron concentrate

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International Journal of Minerals,Metallurgy and Materials 2020年第4期27卷 454-462页

作者： Feng Li Qing-jie Zhao Man-sheng Chu Jue Tang Zheng-gen Liu Jia-xin Wang Sheng-kang Li School of Metallurgy Northeastern UniversityShenyang 110819China State Key Laboratory of Rolling and Automation Northeastern UniversityShenyang 110819China

A new process for preparing high-purity iron(HPI)was proposed,and it was investigated by laboratory experiments and pilot tests.The results show that under conditions of a reduced temperature of 1075°C,reduced time of 5 h,and CaO content of 2.5wt%,a DRI with a metallization rate of 96.5%was obtained through coal-based direct reduction of ultra-high-grade iron concentrate.Then,an HPI with a Fe purity of 99.95%and C,Si,Mn,and P contents as low as 0.0008wt%,0.0006wt%,0.0014wt%,and 0.0015wt%,respectively,was prepared by smelting separation of the DRI using a smelting temperature of 1625°C,smelting time of 45 min,and CaO content of 9.3wt%.The product of the pilot test with a scale of 0.01 Mt/a had a lower impurity content than the Chinese industry standard.An HPI with a Fe purity of 99.98wt%can be produced through the direct reduction?smelting separation of ultra-high-grade iron concentrate at relatively low cost.The proposed process shows a promising prospect for application in the future.

关键词： ultra-high-grade iron concentrate high-purity iron coal-based direct reduction smelting separation pilot test

Quercetin modulates iron homeostasis and iNOS expression of splenic macrophages in a rat model of iron deficiency anemia

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Chinese Journal of Natural Medicines 2018年第8期16卷 580-589页

作者： Maryam Mazhar Nurul Kabir Shabana U Simjee Dr. Panjwani Center for Molecular Medicine and Drug Research International Centerjbr Chemical and Biological SciencesUniversity of Karachi Karachi 75270 Pakistan H.E.J. Research Institute. for Chemistry International CenterJor Chemical and Biological Sciences University of Karachi Karachi 75270 Pakistan

iron deficiency anemia is one of the most common micronutrient deficient conditions around the globe with various consequences,including the weakened immune system.Quercetin is widely distributed bioflavonoid;it has been debated for its dual roles in iron regulation.Quercetin-iron interaction in the body is a complex mechanism which has not been completely understood.The present study aimed to investigate the effect of quercetin on iron supplementation in iron deficiency anemia and on i NOS expression in splenic macrophages.The rat model of iron deficiency anemia was induced by feeding low iron diet to weanling rats for 20 days.The animals were then administered with ferrous sulfate,quercetin,and their combination for 30 days.Blood parameters,histopathological analysis,iron storage,CD68,i NOS and SLC40 expression in rat spleen were investigated.Our results showed that quercetin regulated iron absorption,despite SLC40 down-expression,indicating possible alternate route of iron transport,and that quercetin modulated i NOS production in splenic macrophages..

关键词： iron deficiency anemia Inducible nitric oxide synthase Macrophages Spleen Quercetin

Controllable Macroscopic Architecture of Subtractive Manufactured Porous iron for Cancellous Bone Analogue:Computational to Experimental Validation

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Journal of Bionic Engineering 2020年第2期17卷 357-369页

作者： Muhammad Azfar Noordin Rabiatul Adibah Abdul Rahim Ahmad Nabeel Hakimi Roslan Iza Azura Ali Ardiyansyah Syahrom Amir Putra Md Saad Applied Mechanics and Design School of Mechanical EngineeringFaculty of EngineeringUniversiti Teknologi Malaysia81310 UTM Johor BahruMalaysia Medical Devices and Technology Centre(MEDiTEC) Institute of Human Centred and Engineering(iHumEn)Universiti Teknologi Malaysia81310 UTM Johor BahruMalaysia School of Biomedical&Health Science Faculty of EngineeringUniversiti Teknologi Malaysia81310 UTM Johor BahruMalaysia

Higher strength and lower degradation rate of Fe compared to magnesium and zinc have made it the most reliable for orthopaedic reconstruction.Hence,this paper studies the morphological and mechanical characteristics of porous Fe fabricated using subtractive manufacturing for load bearing bone replacement.Three types of porous Fe(19%,39%and 59%)were prepared and then modelled into a 3D model for finite element analysis.The mechanical properties evaluated through finite element analysis were then validated by the experimental results.Computational fluid dynamics was done in this study to evaluate the permeability and wall shear stress of the porous Fe.Correlations between morphological indices,mechanical properties,shear stress and permeability were then obtained.The mechanical behaviour of porous Fe investigated through finite element analysis was in good agreement with the experimental work.The mechanical properties of porous Fe specimen particularly sample C(modulus:5.63 GPa and yield strength:145.7 MPa)was tailored to the cancellous bone(modulus:0.5 GPa-18 GPa and yield strength:101 MPa-169.6 MPa).As the porosity increased,the performance of porous Fe regarding mechanical properties and morphological properties were enhanced.

关键词： mechanical characterization morphology finite element analysis porous iron shear stress permeability

How does anodization time affect morphological and photocatalytic properties of iron oxide nanostructures?

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Journal of Materials Science & Technology 2020年第3期38卷 159-169页

作者： Bianca Lucas-Granados Rita Sánchez-Tovar Ramón MFernández-Domene JoséMaría Estívalis-Martínez JoséGarcía-Antón Ingeniería Electroquímica y Corrosión(IEC).Instituto Universitario de Seguridad Industrial Radiofísica y Medioambiental(ISIRYM)Universitat Politècnica de ValènciaCamino de Vera s/n46022ValenciaSpain Departmento de Ingeniería Química Universitat de ValènciaAv de les Universitatss/n46100 BurjassotSpain

iron oxide nanostructures are promising materials to be used as photocatalysts in different photoelectrochemical applications. There are different techniques in order to synthesize these nanostructures, but one of the most inexpensive and simple method is electrochemical anodization. This method can lead to different nanostructures by controlling its parameters. Anodization time is one of the most critical parameters since it considerably affects the properties of the obtained nanostructures. In this work, different anodization times(5, 10, 15, 30 and 60 min) were studied. The resulting nanotubes were characterized by field emission scanning electron microscopy, Raman laser confocal microscopy, water splitting measurements, Mott-Schottky analysis and electrochemical impedance spectroscopy, in order to test their viability for being used as photocatalysts in photoelectrochemical applications. Results showed that the best photocurrent density values in water splitting tests(0.263 m A m-2) were achieved for the sample anodized for 10 min under hydrodynamic conditions.

关键词： iron oxide Metallic nanostructures Photoelectrochemistry Anodization Time