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Clinical and microstructural changes with different iontophoresis-assisted corneal cross-linking methods for keratoconus

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International Journal of Ophthalmology(English edition) 2019年第2期12卷 219-225页

作者： Kai Liao Min Hu Fen Chen Pei Li Peng Song Qing-Yan Zeng Aier School of Ophthalmology Central South University Hankou Aier Eye Hospital

AIM: To compare the clinical and microstructural changes induced by different transepithelial iontophoresis-assisted corneal cross-linking(I-CXL) methods for keratoconus. METHODS: A total of 42 eyes of 42 patients with progressive keratoconus were divided into two groups. Group A received I-CXL for 5min, while group B received I-CXL for 10 min. Visual acuity, optical coherence tomography(OCT), specular microscopy and confocal microscopy were evaluated preoperatively and at 1, 3, 6, and 12 mo postoperatively. RESULTS: Twelve months after the operation, uncorrected visual acuity(UCVA) and corrected distance visual acuity(CDVA) were improved in both groups, with a better outcome in the I-CXL 10 min group(P=0.025, 0.021, respectively). Kmax values decreased by 0.94±3.00 D in the I-CXL 10 min group(P=0.033) but increased by 1.87±3.29 D in the I-CXL 5min group(P=0.012). OCT scans showed that the demarcation line was most visible and substantially deeper in the I-CXL 10 min group. Confocal microscopy showed greater anterior stromal keratocyte decreases in the I-CXL 10 min group than in the I-CXL 5min group at 3 and 6mo postoperatively(P<0.001); however, anterior stromal keratocytes and subbasal nerve density were not significantly different between the two groups at 12 mo postoperatively.

关键词： keratoconus transepithelial corneal crosslinking iontophoresis anterior stromal keratocyte subbasal nerve density

iontophoresis-assisted versus standard corneal crosslinking for progressive keratoconus

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Annals of Eye Science 2017年第1期2卷 28-34页

作者： Hong-Zhen Jia Xu Pang Zheng-Jun Fan Xiu-Jun Peng Department of Ophthalmology Chinese PLA Navy General HospitalBeijing 100048China

Background:To compare the safety and efficacy of iontophoresis-assisted epithelial-on corneal crosslinking(I-CXL)using 0.1%riboflavin-distilled water solution with standard epithelium-off corneal crosslinking(S-CXL)for progressive keratoconus.Methods:In a retrospective analysis,progressive keratoconus patients treated with I-CXL(17 eyes of 17 patients)or S-CXL(13 eyes of 13 patients)were included.All patients were followed up at least 12 months.All patients underwent detailed ophthalmologic examinations involving pre-and postoperative visual acuity,topographic parameters and pachymetry.Intra-and postoperative complications were recorded.Results:No statistically significant differences were observed between the two groups at baseline with respect to visual acuity,age and thinnest corneal thickness(TCT).The postoperative decreases of K1 and Kmean in the S-CXL group represented statistically significantly better results than in the I-CXL group(t=2.093 and 2.123,P=0.046 and 0.043,respectively).Alterations of other parameters showed no significant differences between the two groups.There were no failure cases in the two groups.Conclusions:I-CXL using 0.1%riboflavin-distilled water solution provided effective treatment for progressive keratoconus at 12-month follow-up.However,the decreases of K1 and Kmean caused by I-CXL were less than those by S-CXL.Although treatment time,postoperative patient pain and risk of infection in I-CXL are all less than those in S-CXL,I-CXL is unable to completely replace S-CXL for progressive keratoconus temporarily.

关键词： Keratoconus corneal crosslinking iontophoresis riboflavin

Warm Needling Combined with iontophoresis of Chinese Medicine for Temporomandibular Joint Disorder

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Journal of Acupuncture and Tuina Science 2014年第5期12卷 316-320页

作者： Liu Min-juan Mu Jing-ping Han Chou-ping Department of Acupuncture and Moxibustion Taihe HospitalHubei University of Medicine

Objective: To observe the clinical efficacy of warm needling combined with iontophoresis of Chinese medicine for temporomandibular joint disorder(TMD). Methods: A total of 100 TMD cases were randomly allocated into a treatment group and a control group, 50 in each group. Cases in the treatment group were treated with warm needling combined with iontophoresis of Chinese medicine, whereas cases in the control group were treated with Western medication. The therapeutic efficacies in two groups were assessed after three courses of treatment. Results: The recovery rate and total effective rate were 54.0% and 98.0% respectively in the treatment group, versus 30.0% and 82.0% in the control group, showing significant differences(both Piontophoresis of Chinese medicine could substantially shorten the course of treatment. Conclusion: Warm needling combined with iontophoresis of Chinese medicine is remarkably effective for TMD and deserves further clinical application.

关键词：针灸治疗艾灸治疗温暖的刺破治疗 iontophoresis Temporomandibular 联合混乱 R246.2

Therapeutic Efficacy Observation on Point-toward-point Acupuncture Combined with Herbs iontophoresis for Knee Osteoarthritis

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Journal of Acupuncture and Tuina Science 2013年第5期11卷 318-321页

作者： Li Shi-sheng Wu Yao-chi Zhang Jun-feng Zhou Jing-hui Deng Ying No.6 People’s Hospital Affiliated to Shanghai Jiaotong University

Objective:To observe the clinical efficacy of point-toward-point acupuncture combined with herbs iontophoresis in treating knee osteoarthritis.Methods:A total of 100 patients were randomly divided into a treatment group and a control group,50 cases in each.Patients in the treatment group received point-toward-point acupuncture with long needle combined with herbs iontophoresis treatment;while those in the control group were only treated by point-toward-point acupuncture with long needle.Clinical efficacies of the two groups were compared after treatment.Results:The total effective rate was 92.0%in the treatment group,versus 82.0%in the control group,and the difference was statistically significant(Piontophoresis treatment for knee osteoarthritis has a significant effect.

关键词： iontophoresis 针灸治疗 Point-toward-point 方法针灸药联合了骨关节炎膝 R246.2

Effects of ginger moxibustion combined with Chinese medicine iontophoresis on patients with primary dysmenorrhea

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Journal of Hainan Medical University 2019年第22期25卷 49-54页

作者： Jie-Li Guo Tian Yu Feng-Chao Dao Mei-Rong Du Xiu-Min Liu Xiu-Ling Xing Department of traditional Chinese medicine Maternal and Child Health Hospital TangShanTangShanHeiBei063000China

Objective:To observe the effects of Ginger moxibustion combined with iontophoresis with traditional Chinese medicine on the improvement of symptoms, serum platelet activating factor (PAF) level and uterine artery pulsation index in patients with primary dysmenorrhea.Methods 114 patients with primary dysmenorrhea who were treated in our hospital from August 2017 to February 2019 were divided into two groups according to the different treatment schemes. 57 patients in the control group were treated with ibuprofen capsules, and 57 patients in the study group were treated with Ginger moxibustion combined with iontophoresis with traditional Chinese medicine. After three menstrual cycles of treatment, the curative effect was evaluated and the improvement of symptoms was counted. PAF, PAF-AH and platelet adhesion rate were compared, uterine artery hemodynamics was measured, and levels of serum hs-CRP and IL-6 were measured.Results The overall response rate of the study group was significantly higher than that of the control group (P < 0.05). After treatment, the scores of different symptoms in the two groups were significantly lower than those before treatment (P < 0.05), and the scores of different symptoms in the study group were significantly lower than those in the control group (P < 0.05). After treatment, PAF and platelet adhesion rate in the two groups were significantly lower than those before treatment (P < 0.05), PAF-AH was significantly higher than that before treatment (P < 0.05), and PAF and platelet adhesion rate in the study group were significantly lower than those in the control group (P < 0.05), PAF-AH was significantly higher than that in the control group (P < 0.05). After treatment, the pulsation index, resistance index and peak systolic-diastolic ratio in the study group were significantly lower than those before treatment (P < 0.05), and the pulsation index, resistance index and peak systolic-diastolic ratio in the study group were significantly lower than those in the control group (P < 0.05). Af

关键词： Ginger moxibustion iontophoresis with traditional Chinese medicine primary dysmenorrhea improvement of symptoms serum platelet activating factor level uterine artery pulsation index

Corneal collagen cross‑linking epithelium‑on vs.epithelium‑off:a systematic review and meta‑analysis

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Eye and Vision 2021年第6期8卷 338-352页

作者： Francesco D’Oria Antonio Palazón Jorge L.Alio Vissum Innovation c/Cabañal103016 AlicanteSpain Division of Ophthalmology Universidad Miguel HernándezAlicanteSpain Section of Ophthalmology Department of Basic Medical ScienceNeuroscience and Sense OrgansUniversity of BariBariItaly Department of Clinical Medicine Miguel Hernández UniversitySan Juan de AlicanteSpain

Background:The purpose of the study was to determine the advantages and disadvantages of epi-on corneal crosslinking(CXL)techniques compared with standard epi-off CXL.Methods:We searched MEDLINE and EMBASE for randomized controlled trials(RCTs)and non-randomized studies of interventions(NRSIs)and we evaluated the selected papers according to the Cochrane risk of bias tool.We considered,as primary outcomes,average Kmax flattening,changes in uncorrected and corrected distance visual acuity(UDVA and CDVA);as secondary outcomes,we considered changes in pachymetry values and endothelial cell density(ECD).We also investigated adverse events related to the treatments and treatment failure.Meta-analysis was conducted with a fixed or random-effects model using weighted mean difference(MD)with 95%confidence interval(CI)as the effect size.Results:A total of 15 studies were included and among these 15 trials,9 were RCTs and 6 were NRSIs,but only 4 studies showed no high risk of bias and were included in this meta-analysis.Our analysis revealed significant postoperative differences in CDVA(MD=0.07;95%CI 0.04 to 0.10;P0.05).Epi-on CXL protocol was found to be significantly less prompt to have risks of delay in epithelial healing(P=0.035)and persistent stromal haze(P=0.026).Conclusion:Epi-on CXL is as effective as epi-off CXL.Except for a higher significant improvement in CDVA with current epi-on protocols,our meta-analysis demonstrates that epi-on and epi-off CXL have comparable effects on visual,topographic,pachymetric,and endothelial parameters.Epi-on CXL has clinical advantages in terms of comfort and avoidance of complications as it reduces the risk of developing delay in epithelial healing and persistent stromal haze.

关键词： Corneal collagen cross-linking Keratoconus Transepithelial CXL Epithelium-off CXL Epithelium-on CXL iontophoresis

Relationship between transdermal energy of electroporation and iontophoresis and permeably fluxes of tetracaini hydrochlordum and naproxenum

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Chinese Journal of Biomedical Engineering(English Edition) 2000年第2期9卷 76-85页

作者： BAO Jia li 1, HU Qiao hong 2, LANG Wen quan 2, GAO Jian qing 2, WU Ping 11.Clinical Engineering Institute, Zhejiang University, Hangzhou 310006, China 2.Pharmaceutics Institute,Zhejiang University,Hangzhou 310006, China

Transdermal drug delivery (TDD) using electroporation is an attractive novel method of facilitated transport of compounds across skin that a short electrical pulse is applied to the skin, forcing the creation of a reversible transient aqueous pore to enhance drugs transdermal permeability. Most of prior researches are difficult to put into the practical use, such as stimulation for user and designing electroporater apparatus for TDD, due to pulse with high intensive. In this paper, the effect of electroporative energy on the transdermal fluxes of Tetracaini Hydrochlordum (TH) and Naproxenum is studied to explore a way of electroporative technique with low voltage. We applied a 120 V and 4.2 J square pulse to SD male rats skin on abdomen, the transdermal flux of TH increased 5.1 times more than the passive transport. While a 400 V and 37.6 J exponential decaying pulse was employed to same skin, the transdermal flux of Naproxenum was 3.5 times than passive transport. The results show that: (1) drugs transdermal permeably flux will create a saturation as the electroporative energy raises to threshold; (2) the transdermal energy efficiency (F/E value) declines as time extends; and (3) the effect of electroporation is concerned with the transdermal energy and drugs characteristics, electroporation is more effective than iontophoresis for TH, but conversely for Naproxenum.

关键词： transdermal drug delivery (TDD) electroporation iontophoresis energy efficiency (F/E value) tetracaini hydrochlordum naproxenum

5% Ibuprofen iontophoresis Compared with Transcutaneous Electrical Nerve Stimulation in the Management of Knee Osteoarthritis: A Feasibility Study

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Open Journal of Therapy and Rehabilitation 2014年第4期2卷 166-172页

作者： Ajediran I. Bello Shika Kuwornu Department of Physiotherapy School of Biomedical and Allied Health Sciences College of Health Sciences University of Ghana Accra Ghana

Objective: The study compared the inclusions of 5% ibuprofen iontophoresis and Transcutaneous Electrical Nerve stimulation (TENS) in the management of osteoarthritis (OA) of the knee joint. Subjects and Methods: Patients diagnosed with knee OA and referred for physiotherapy at a tertiary health facility in Accra, Ghana participated in the study. They were alternately assigned into either TENS or iontophoresis groups. Patients in TENS Group received conventional TENS mode while those in iontophoresis group were treated with 5% ibuprofen iontophoresis using galvanic electrical current. Both protocols were performed twice weekly for six weeks in addition to their prescribed therapeutic exercises. 15-minute walking time, Numerical Rating Scale and Goniometer were used as the main outcome measures to determine subjects’ walking speed, pain and active range of motion (AROM) respectively. Treatment evaluation was performed at baseline, week 3 and week 6 by an independent assessor. Comparisons of variables within and between groups were tested using Friedman’s mean rank and Mann-Whitney U tests respectively at p 0.05) for all the outcome measures. Conclusion: 5% ibuprofen iontophoresis and TENS add equal therapeutic value in the management of knee OA. Consideration of both modalities as adjuncts to therapeutic exercises is therefore worthwhile for managing the condition.

关键词： Ibuprofen TENS Osteoarthritis iontophoresis

Surging footprints of mathematical modeling for prediction of transdermal permeability

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Asian Journal of Pharmaceutical Sciences 2017年第4期12卷 299-325页

作者： Neha Goyal Purva Thatai Bharti Sapra Pharmaceutics Division Department of Pharmaceutical Sciences Punjabi University

In vivo skin permeation studies are considered gold standard but are difficult to perform and evaluate due to ethical issues and complexity of process involved. In recent past, a useful tool has been developed by combining the computational modeling and experimental data for expounding biological complexity. Modeling of percutaneous permeation studies provides an ethical and viable alternative to laboratory experimentation. Scientists are exploring complex models in magnificent details with advancement in computational power and technology. Mathematical models of skin permeability are highly relevant with respect to transdermal drug delivery, assessment of dermal exposure to industrial and environmental hazards as well as in developing fundamental understanding of biotransport processes.Present review focuses on various mathematical models developed till now for the transdermal drug delivery along with their applications.

关键词： Mathematical models Multiple linear regression Artificial neural network iontophoresis based models Compartmental modeling Porous pathway models