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glutamate and excitotoxicity in central nervous system disorders:ionotropic glutamate receptors as a target for neuroprotection

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Neuroprotection 2024年第2期2卷 137-150页

作者： Jorge Y.Magdaleno Roman Christian Chapa Gonzalez Instituto de Ingenieria y Tecnologia Universidad Autonoma de Ciudad JuarezCiudad JuarezMexico Grupo de Nanomedicina Laboratorio de Integracionde Datosy Evidenciaen Revisiones de Salud y Ciencia(LIDERSC)Universidad Autonoma de Ciudad JuarezCiudad JuarezMexico

Recent advances in neuroscience have illuminated the central role of glutamate dysregulation in various neurological *** glutamatergic system has emerged as a central player in the pathophysiology of various neurological *** dysregulation of glutamate signaling,leading to excitotoxicity and neuronal cell death,has been a focal point in understanding the underlying mechanisms of these *** has prompted a paradigm shift in neuroprotection research,with a growing emphasis on targeting ionotropic glutamate receptors(iGluRs)to restore glutamatergic *** review provides a comprehensive overview of recent advancements in the field of iGluR-targeted *** further investigate the implications of glutamate dysregulation in the central nervous system(CNS)disorders,highlighting the complex interplay between excitotoxicity and *** elucidate the multifaceted factors that render neurons vulnerable to excitotoxic damage,emphasizing the need for innovative therapeutic *** review provides an extensive survey of the burgeoning field of iGluR-targeted *** showcases the significant potential of a wide array of compounds,encompassing both natural and synthetic agents,to modulate iGluRs and ameliorate excitotoxicity and oxidative stress-induced neuronal *** compounds have demonstrated impressive neuroprotective effects in diverse experimental models,from glutamate-induced toxicity to traumatic brain *** advocate for further research and clinical investigations to harness the full therapeutic potential of iGluR modulation,heralding a promising era in neuroprotection and CNs disorder management.

关键词： central nervous system excitotoxicity glutamate ionotropic glutamate receptors neuroprotection

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Mechanisms of glutamate metabolic function and dysfunction in vasculardementia

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Neuroprotection 2024年第1期2卷 33-48页

作者： Jiawen Wang Yingmei Zhang Ning Tian Dongshan Ya Jiaxin Yang Yanlin Jiang Xiaoxia Li Xiaohui Lin Bin Yang Qinghua Li Rujia Liao Laboratory of Neuroscience Afliated Hospital of Guilin Medical UniversityGuilin Medical UniversityGuilinGuangxiChina Department of Neurology Affliated Hospital of Guilin Medical UniversityGuilin Medical UniversityGuilinGuangxiChina Department of Pharmacology Affliated Hospital of Guilin Medical UniversityGuilin Medical UniversityGuilinGuangxiChina Department of Geriatrics Affliated Hospital of Guilin Medical UniversityGuilin Medical UniversityGuilinGuangxiChina Guangxi Clinical Research Center for NeurologicalDiseases Afiliated Hospitalof Guilin Medical UniversityGuilin Medical UniversityGuilinGuangxiChina

As the global population ages,research on the pathogenesis and treatment options for older patients with dementia has become increasingly *** dementia(VaD),the second most frequent type of dementia,is characterized by vascular impairment caused by inadequate blood supply to the *** is a complex neurological disorder involving multiple cells and signaling pathways,and its prevention and treatment pose clinical challenges with significant behavioral ***,the most abundant amino acid in the brain,plays a critical role as an excitatory neurotransmitter,impacting cognitive function,learning,and *** glutamate metabolism has been closely linked to dementia,and reduced blood flow to the brain can lead to excessive glutamate accumulation,resulting in neuronal *** article highlights the connection between VaD and glutamate metabolism,aiming to identify better methods for preventing and treating VaD via regulating glutamate metabolism.

关键词： glutamate ionotropic glutamate receptors metabolism metabotropic glutamate receptors vasculardementia

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Mechanism of charged interface of stargazin EX1 on AMPAR opening and desensitization

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中国药理学与毒理学杂志 2021年第9期35卷 685-686页

作者： YANG Zu-xiao ZHANG Wei Department of Pharmacology of Chinese Materia Medica Institution of Chinese Integrative Medicinethe Key Laboratory of New Drug Pharmacology and ToxicologyHebei Medical UniversityShijiazhuang 050017China

OBJECTIVE AMPA-subtype iono⁃tropic glutamate receptors(iGluRs)mediate fast excitatory synaptic transmission in the mammali⁃an central nervous system(CNS).It plays the key role in many central nerves disorder such as epilepsy,depression and ***⁃gazin(STZ,also named TARP-γ2),as the first TARPs found in CNS,potentiates AMPAR activity by attenuating deactivation and desensitization,enhancing recovery from desensitization,and facilitating agonist affinity and ***,it is still not fully understanding howγ-2 modu⁃late AMPAR *** AND RESULTS The desensitization for different mutation of AMPAR andγ-2 was *** was shown that the electric attraction was involved in the interaction of AMPAR andγ-*** addition,the interaction of KGK motif in ligand binding domain and pre-M1 chain of AMPAR and EX1 ofγ-2 modulate AMPAR opening and *** of these charged residues had sur⁃prisingly effects on AMPAR desensitization kinet⁃*** The electric attraction has two impacts on the channels gating process the first destablizing the receptor closed state and enabling the channel opening,the second pro⁃moting the channels entering desensitization state upon the channel opening.

关键词： ionotropic glutamate receptors desensitization stargazin EX1

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Effects of NMDA and AMPA receptors in the hippocampal CA1 region during learning-dependent LTP in conscious rats

Effects of NMDA and AMPA receptors in the hippocampal CA1 re...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Shi WANG~1,Jun WANG~1,Dan WANG~1,Cheng-Xi WEI~2,Qing-Hua JIN~(1,*) 1 Department of Physiology and Pathophysiology,Yanbian University Medical College,Yanji 133002 China 2 Institute of Neurosurgery,Affiliated Hospital of Inner Mongolia Nationality University,Tongliao 028007 China

＜正＞Hippocampus is one of the important sites for mammalian learning and memory,and Long-term potentiation （LTP）is a potential neurophysiological mechanism responsible for learning and *** several in vitro studies indicate that glutamate（Glu）and it’s ionotropic receptors involved in the hippocampal LTP,however,little is known about the underlying neurophysiological mechanisms of hippocampal learning-dependent LTP in conscious and freely moving *** this work,glutamate receptor antagonists MK-801and CNQX were locally microinjected into the hippocampal CA1 region,then the extracellular concentration of Glu and amplitude of the field excitatory postsynaptic potential（fEPSP）-LTP in CA1 region were measured during the period of establishment and experimental extinction of the conditioned reflex in conscious rats.

关键词： hippocampal CA1 region learning-dependent LTP ionotropic glutamate receptors conscious rats

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