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Modulation of neuronal dynamic range using two different adaptation mechanisms

Neural Regeneration Research 2017年第3期12卷 447-451页

作者： Lei Wang Ye Wang Wen-long Fu Li-hong Cao Neuroscience and Intelligent Media Institute Communication University of ChinaBeijingChina

The capability of neurons to discriminate between intensity of external stimulus is measured by its dynamic range.A larger dynamic range indicates a greater probability of neuronal *** this study,the potential roles of adaptation mechanisms（ion currents） in modulating neuronal dynamic range were numerically *** on the adaptive exponential integrate-and-fire model,which includes two different adaptation mechanisms,*** and suprathreshold（spike-triggered） adaptation,our results reveal that the two adaptation mechanisms exhibit rather different roles in regulating neuronal dynamic ***,subthreshold adaptation acts as a negative factor that observably decreases the neuronal dynamic range,while suprathreshold adaptation has little influence on the neuronal dynamic ***,when stochastic noise was introduced into the adaptation mechanisms,the dynamic range was apparently enhanced,regardless of what state the neuron was in,*** or *** model results suggested that the neuronal dynamic range can be differentially modulated by different adaptation ***,noise was a non-ignorable factor,which could effectively modulate the neuronal dynamic range.

关键词： nerve regeneration dynamic range subthreshold adaptation suprathreshold adaptation noise neuron adaptive exponential integrate-and-fire model ion currents computer simulation neural regeneration

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Expression of ion-channel subunit mRNA in different regions of canine right atrium

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Chinese Medical Journal 2006年第4期119卷 335-338页

作者： HUANG Cong-xin JIANG Hong WANG Teng XU Lin Department of Cardiology Renmin Hospital Wuhan University Wuhan 430060 China

A trial electrophysiological heterogeneity, which plays an important role in the genesis and maintenance of atrial arrhythmia, is a major determinant of atrial reentrant arrhythmias. Recently, many studies on atrial flutter have demonstrated the anatomic architecture in the right atrium plays an important role in the genesis of atrial reentry. The crista terminalis （CT） in the right atrium, which is a unique anatomic structure of the right atrium, provides an area for conduction block and delay, leading to initiation, maintenance, and termination of atrial arrhythmias. Catheter ablation of CT can successfully eliminate these atrial arrhythmias. These literatures contrast with limited knowledge of the basic electrophysiological properties of CT and how these promote arrhythmia generation. Compared to pectinate muscles （PM） and right atrial appendage （RAA）, CT have distinct electrophysiological properties related to different densities of several ionic currents, the transient outward current （Ito） and L-type Ca^2＋ current （Ica-L） underlie the bulk of the different densities of several ionic currents. Cardiac Ito and Ica-L play a major role in action potential repolarization. Ito is particularly important in early （phase 1） repolarization and influences the participation of other currents. It is generally believed that Ica-L plays an important role in the plateau phase of repolarization. However, the mechanisms for these ionic current differences are unknown. One possible is a difference in ion channel subunit expression, but virtually no data are available regarding ion-channel subunit expression in CT, PM, and RAA. The Kv4.3 channel underlies the bulk of the α-subunit of Ito in canine and human heart.

关键词： arrhythmia ion currents repolarization right atrium

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