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Blood group type antigens in pancreatic intraductal papillary mucinous neoplasms

Hepatobiliary & Pancreatic Diseases International 2014年第1期13卷 74-80页

作者： Adriana Handra-Luca Departments of Pathology Sydney Kimmel Comprehensive Cancer Center Johns Hopkins Medical Institutions APHP Universite Paris Nord Sorbonne Cite-Sce Anatomie Pathologique GHU Avicenne 125 rue Stalingrad Bobigny 93000 France

BACKGROUND: There are few data on blood group(BG) types and types of pancreatic cancers. The aims of this study were to study BG types and BG-antigens in pancreatic intraductal papillary mucinous neoplasms(IPMNs). METHODS: BG type and tumor BG-antigen(glycoprotein) expression(studied by immunohistochemistry on tissue microarrays) were analyzed with regard to characteristics of 101 surgically resected pancreatic IPMNs. RESULTS: Non-O BG type predicted invasive carcinoma independently from high serum CA19-9 and male gender. BG type A was observed more frequently in women than in men. Chronic pancreatitis was more frequently seen in patients with BG type B or AB. Aberrant tumor expression(with regard to BG type) of loss of A antigen expression type occurred in 15.0% of IPMNs and of loss of B antigen expression type in 62.5% of IPMNs. Intraneoplasm BG-antigen expression was not related to dysplasia grade or invasion. CONCLUSION: The results of the study suggest that in pancreatic IPMN, non-O BG type predicted invasive carcinoma, whereas for intratumor BG-antigen expression no specific patterns were detected with regard to the progression of glandular epithelial dysplasia or invasion.

关键词： blood group type blood group antigen immunohistochemistry CA19-9 prognosis invasive carcinoma pancreas intraductal papillary mucinous neoplasm

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Malignancy risk factors and prognostic variables of pancreatic mucinous cystic neoplasms in Chinese patients

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World Journal of Gastroenterology 2023年第20期29卷 3119-3132页

作者： Qing Xia Fan Li Rui Min Shuai Sun Yue-Xin Han Zhen-Zhong Feng Nan Li Department of Pathology The First Affiliated Hospital of Bengbu Medical CollegeBengbu Medical CollegeBengbu 233004Anhui ProvinceChina Department of Pathology Bengbu Medical CollegeBengbu 233030Anhui ProvinceChina School of Clinical Medicine Bengbu Medical CollegeBengbu 233030Anhui ProvinceChina Department of Pathology The Second Affiliated Hospital of Anhui Medical UniversityHefei 230601Anhui ProvinceChina

BACKGROUND Pancreatic mucinous cystic neoplasms(MCNs)represent one of the precursor lesions of pancreatic ductal adenocarcinoma,and their detection has been facilitated by advances in preoperative *** primarily to the rarity of MCNs,however,there is limited knowledge regarding the prognostic variables and high-risk factors for malignant transformation.A more comprehensive and nuanced approach is necessary to fill this gap and provide a basis for improved treatment decisions and patient *** To investigate the high-risk factors associated with malignant MCNs and to explore the prognostic factors of MCN with associated invasive carcinoma(MCNAIC).METHODS All cases of resected MCNs from a single high-volume institution between January 2012 and January 2022 were retrospectively *** cases with ovarian-type stroma verified by progesterone receptor staining were *** features,histological findings and postoperative course were *** logistic regression was employed to investigate variables related to *** analysis was performed using the Kaplan-Meier curve,and the prognostic factors were assessed to evaluate the postoperative course of patients with *** Among the 48 patients,36 had benign MCNs,and 12 had malignant MCNs(1 high-grade atypical hyperplasia and 11 MCN-AIC).Age,tumour size,presence of solid components or mural nodules and pancreatic duct dilatation were identified as independent risk factors associated with *** follow-up period ranged from 12 mo to 120 mo,with a median overall survival of 58.2 *** three patients with MCN-AIC died,and the 5-year survival rate was 70.1%.All 11 cases of MCN-AIC were stage I,and extracapsular invasion was identified as a prognostic factor for poorer *** The risk factors independently associated with malignant transformation of MCNs included age,tumour size,presence of solid components or mural nodules,and pancreatic

关键词： Mucinous cystic neoplasms Pancreatic adenocarcinoma invasive carcinoma Risk of malignancy Prognostic factor Retrospective study

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Update on mucinous cystic neoplasm of the pancreas:a narrative review

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Journal of Pancreatology 2021年第3期4卷 115-121页

作者： Wen Xie Huaiyu Liang Yan Guo Shu-Yuan Xiao Department of Pathology Zhongnan Hospital of Wuhan UniversityWuhan University Center for Pathology and Molecular DiagnosticsWuhanHubei Province Department of Pathology Ruijin HospitalShanghai Jiao Tong University School of Medicine Histopathology Diagnostic Center ShanghaiChina Department of Pathology University of Chicago MedicineChicago 60637ILUSA

Mucinous cystic neoplasm(MCN)of the pancreas is an exocrine cystic tumor with a potential of harboring *** latest World Health Organization classification of tumors of digestive system designates malignant MCN as MCN with associated invasive carcinoma(MCN-AIC).Since its separation from other pancreatic cystic tumors in 1978,much progress has been made in our understanding of MCN in epidemiology,clinical and pathological features,biological behavior,as well as prognostic *** review aims to summarize the current knowledge of MCN and MCN-AIC.

关键词： invasive carcinoma Molecular genetics Mucinous cystic neoplasm Ovarian-type stroma Prognosis

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胰腺导管内乳头状粘液瘤恶变的相关预测因素分析

胰腺导管内乳头状粘液瘤恶变的相关预测因素分析

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作者： Harsha Ajoodhea 浙江大学

学位级别：硕士

目的：筛选胰腺导管内乳头状粘液瘤发生恶变的相关预测因素。方法：回顾性分析在邵逸夫医院自2002年到2014年所有诊断为胰腺导管内乳头状粘液瘤患者的资料。根据文献及临床经验,设立26个相关因素,通过单因素分析、Logist回归分析及ROC分... 详细信息

目的：筛选胰腺导管内乳头状粘液瘤发生恶变的相关预测因素。方法：回顾性分析在邵逸夫医院自2002年到2014年所有诊断为胰腺导管内乳头状粘液瘤患者的资料。根据文献及临床经验,设立26个相关因素,通过单因素分析、Logist回归分析及ROC分析,筛选术前可以预测胰腺导管内乳头状粘液瘤恶变的相关因素。结果：术前AST (P<0.004)和ALT (P<0.002)水平,主胰管直径≥5mm(P<0.002),囊肿≥3cm(P<0.033),CT增强的固体成分(P<0.026)和主胰管直径突然变化与远端胰腺萎缩(P<0.015)与胰腺导管内乳头状粘液瘤恶变有相关性。饮酒量(P<0.046),术前AST (P<0.031)和ALT (P<0.043)水平,主胰管直径≥5mm(P<0.015),囊肿大小≥3cm(P<0.019),增强的固体成分(P<0.033),主胰管直径突然变化与远端胰腺萎缩(P<0.046)和胰腺导管内乳头状粘液瘤具有侵袭性有相关性。主胰管直径可能是预测胰腺导管内乳头状粘液瘤恶变和侵袭的关键因素[0.791(P<0.002,95%CI:0.668-0.913) and0.772(P<0.010,95%CI:0.635-0.909).结论：囊肿≥3cm,主胰管≥5mm,增强的固体成分,主胰管突然变化与远端胰腺萎缩以及术前ALT和AST水平与胰腺导管内乳头状粘液瘤恶变相关,其中主胰管直径是最重要的因素。饮酒史与胰腺导管内乳头状粘液瘤侵袭性相关。

关键词： Intraductal papillary Mucinous Neoplasm Pancreatic Cystic Lesions Malignancy invasive carcinoma Alcohol

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