检索结果-南通市图书馆

intravitreal injection of resveratrol inhibits laser-induced murine choroidal neovascularization

International Journal of Ophthalmology(English edition) 2020年第6期13卷 886-892页

作者： Hui-Ming Zhang Xiao-Hua Li Mingjiazi Chen Jing Luo Department of Dermatology the Second Xiangya HospitalCentral South UniversityChangsha 410011Hunan ProvinceChina Hunan Key Laboratory of Medical Epigenomics Changsha 410011Hunan ProvinceChina Department of Pathology and Ophthalmology Keck School of Medicine at University of Southern CaliforniaLos AngelesCalifornia 90033USA Henan Provincial People's Hospital/Henan Eye Hospital Henan Eye InstituteHenan Key Laboratory of Ophthalmology and Vision Science/Department of OphthalmologyPeople’s Hospital ofZhcngzliou University/Department of OphthalmologyPeople's Hospital of Henan UniversityZhengzhou 450003Henan ProvinceChina 5Department of Ophthalmologythe Second Xiangya I IospitalCentral South UniversityChangsha 410011Hunan ProvinceChina

AIM:To determine the effects of intravitreal resveratrol(RSV)on murine laser-induced choroidal neovascularization(CNV).METHODS:The toxicity of RSV to choroidal endothelial cell(CEC)was measured using thiazolyl blue tetrazolium bromide(M一)*** of RSV on choroidal endothelial cell(CEC)migration were evaluated with a modified Boyden chamber assay,while tube formation was evaluated in a 2-D gel *** was induced by laser photocoagulation in *** effects of intravitreal injection of RSV on CNV development were evaluated by fluorescein angiography(FA),confocal analysis of isolectin B4 labeled choroidal flat mounts,and histologic examination of CNV *** was used to analyze the expression and phosphorylation of vascular endothelial growth factor receptor 2(VEGFR2).RESULTS:No significant cell toxicity was observed in CEC if the concentration of RSV was less than 200 pmol/L(P>0.05).RSV inhibited vascular endothelial growth factor(VEGF)-induced CEC migration(Pintravitrealinjectionof RSV significantly inhibited laser induced CNV formation in *** FA leakage,CNV volume and CNV area analysis revealed that there were 41%,45%,and 58%reduction in RSV-treated eyes(1.691±0.1032,178163±78623μm^3 and 6508±619.0μm^2,respectively)compared with those in control(2.724±0.08447,379676±98382μm3and16576±2646μm^2,respectively;Pintravitreal injection of RSV exerts an inhibitory effect on CNV,which may through suppressing endothelial cell migration,tube formation and VEGFR2 phosphorylation.

关键词： resveratrol intravitreal injection choroidal neovascularization vascular endothelial growth factor receptor 2 tube formation murine

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Combination of cataract surgery with intravitreal injection of dexamethasone intravitreal implant(Ozurdex)for uveitis-induced cataract

引用

International Journal of Ophthalmology(English edition) 2023年第3期16卷 361-366页

作者： Jin Deng Wen-Tao Sun Hua Ai Li-Ping Wang Xi’an People’s Hospital(Xi’an Fouth Hospital) Shaanxi Eye HospitalAffiliated People’s Hospital of Northwest UniversityXi’an 710004Shaanxi ProvinceChina

AIM:To evaluate the long-term results of patients with chronic uveitis-induced cataract by phacoemulsification with IOL implantation and intravitreal injection of dexamethasone(DEX)intravitreal implant(Ozurdex).METHODS:The study included 32 eyes of 26 patients treated with DEX implant due to chronic uveitis-induced cataract and followed up for at least a ***-corrected visual acuity(BCVA),intraocular pressure(IOP),anterior chamber reaction,central macular thickness(CMT),intraoperative and postoperative complications and uveitis recurrence were analyzed ***:A successful surgery was performed in all *** average follow-up period was *** female/male ratio was 13/*** age was 45.65±3.83y(range 26 to 65y).Etiologically,rheumatic arthritis occurred in 6 patients(18.75%),ankylosing spondylitis in 4(12.50%),HLA-B27 associated uveitis in 3(9.38%),Vogt-KoyanagiHarada-associated uveitis in 4(12.50%),Behcet’s disease in 2(6.25%),and 7(21.88%)suffered from unknown *** 32 eyes had varying degrees of improvement at 12mo after surgery,with 2 eyes showing BCVA of 0.1 or below(6.25%),6 having 0.1-0.5(18.75%),18 of 0.5-1.0(56.25%),and 6 of 1.0 or above(18.75%).No cases with increased IOP were *** values of mean CMT was increased at day 1,decreased at 1,3mo after surgery and increased at 6,12mo after *** severe uveitis reactions,such as fibrinous exudates in the anterior chamber and exudative membrane formation on the anterior surface of the IOL,were observed after ***:The present studies show that intravitreal injection of Ozudex during cataract operation can provide a new option for the clinical treatment of uveitis-induced cataract.

关键词： uveitis-induced cataract dexamethasone implant intravitreal injection

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Pharmacokinetics and distributions of bevacizumab by intravitreal injection of bevacizumab-PLGA microspheres in rabbits

引用

International Journal of Ophthalmology(English edition) 2015年第4期8卷 653-658页

作者： Zhuo Ye Yan-Li Ji Xiang Ma Jian-Guo Wen Wei Wei Shu-Man Huang Department of Ophthalmology the First Affiliated Hospital of Dalian Medical University The Institute of Clinical Medicine the First Affiliated Hospital of Zhengzhou University Department of Ophthalmology the Second People's Hospital of Zhengzhou

· AIM: To investigate the pharmacokinetics and distributions of bevacizumab by intravitreal injection of prepared bevacizumab-poly(L-lactic-co-glycolic acid)(PLGA) microspheres in rabbits, to provide evidence for clinical application of this kind of bevacizumab sustained release dosage form.·METHODS: Bevacizumab was encapsulated into PLGA microsphere via the solid- in- oil- in- hydrophilic oil(S/O/h O) method. Fifteen healthy New Zealand albino-rabbits were used in experiments. The eyes of each rabbit received an intravitreal injection. The left eyes were injected with prepared bevacizumab-PLGA microspheres and the right eyes were injected with bevacizumab solution. After intravitreal injection, rabbits were randomly selected at day 3, 7, 14, 28 and 42 respectively, three animals each day. Then we used immunofluorescence staining to observe the distribution and duration of bevacizumab in rabbit eye tissues, and used the sandwich ELISA to quantify the concentration of free bevacizumab from the rabbit aqueous humor and vitreous after intravitreal injection.·RESULTS: The results show that the concentration of bevacizumab in vitreous and aqueous humor after administration of PLGA formulation was higher than thatof bevacizumab solution. The T1/2of intravitreal injection of bevacizumab-PLGA microspheres is 9.6d in vitreous and 10.2d in aqueous humor, and the T1/2of intravitreal injection of soluble bevacizumab is 3.91 d in vitreous and4.1d in aqueous humor. There were statistical significant difference for comparison the results of the bevacizumab in vitreous and aqueous humor between the left and right eyes(P <0.05). The AUC0-tof the sustained release dosage form was 1-fold higher than that of the soluble form. The relative bioavailability was raised *** immunofluorescence staining of PLGA-encapsulated bevacizumab(b-PLGA) in rabbit eye tissues was still observed up to 42 d. It was longer than that of the soluble form.· CONCLUSION: The result of this stud

关键词： bevacizumab-PLGAmicrospheres intravitreal injection sustained release pharmacokinetic immunohistochemistry

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effect of intravitreal injection of bevacizumab-chitosan nanoparticles on retina of diabetic rats

引用

International Journal of Ophthalmology(English edition) 2014年第1期7卷 1-7页

作者： Yan Lu Nan Zhou Xiao Huang Jin-Wei Cheng Feng-Qian Li Rui-Li Wei Ji-Ping Cai Department of Ophthalmology Changzheng Hospital the Second Affiliated Hospital of the Second Military Medical University Department of Ophthalmology Jinling Hospital School of Medicine Nanjing University

AIM:To investigate the effects of intravitreal injection of bevacizumab-chitosan nanoparticles on pathological morphology of retina and the expression of vascular endothelial growth factor(VEGF)protein and VEGF mRNA in the retina of diabetic rats.·METHODS:Seventy-two 3-month aged diabetic rats were randomly divided into 3 groups,each containing 24animals and 48 *** eyes of the rats in group A were injected into the vitreous at the pars plana with 3μL of physiological saline,while in groups B and C were injected with 3μL(75μg)of bevacizumab and 3μL of bevacizumab-chitosan nanoparticles(containing 75μg of bevacizumab),*** was used to assess retinal angiogenesis,real-time PCR assay was used to analyze the expression of VEGF mRNA,and light microscopy was used to evaluate the morphology of retinal capillaries.·RESULTS:Real-time PCR assay revealed that the VEGF mRNA expression in the retina before injection was similar to 1 week after injection in group A(P>0.05),while the VEGF mRNA expression before injection significantly differed from those 4 and 8 weeks after injection(Pinjection(Pinjection(Pinjection was higher than at 1,4 and 8 weeks after injection(Pinjection than 1 week or 4 weeks after injection,andalso higher 1 week after injection compared with 4 weeks after injection(Pinjection alone.·CONCLUSION:The results offer a new approach for inhibiting angiogenesis of diabetic retinopathy and indicate that the intravitreal injection of bevacizumab inhibits VEGF expre

关键词： bevacizumab nanoparticles diabetic retinopathy intravitreal injection

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effects of perioperative managements on ocular surface microbiota in intravitreal injection patients

引用

International Journal of Ophthalmology(English edition) 2022年第2期15卷 248-254页

作者： Ya-Guang Hu Qiong Wu Tian-Hui Li Fang Sui Ming Zhang Zhen Zhang Rui Shi Na Hui Li Qin Li Li Department of Ophthalmology the First Affiliated Hospital of Xi'an Jiaotong UniversityXi'an 710061Shaanxi ProvinceChina Department of Ophthalmology Northwest Women and Children's HospitalXi'an 710061Shaanxi ProvinceChina Key Laboratory of Biomedical Information Engineering Ministry of EducationXi'an 710049Shaanxi ProvinceChina Department of Biomedical Engineering School of Life Science and TechnologyXi'an Jiaotong UniversityXi'an 710049Shaanxi ProvinceChina Department of Otorhinolaryngology-Head and Neck Surgery the First Affiliated Hospital of Xi'an Jiaotong UniversityXi'an 710061Shaanxi ProvinceChina Department of Ophthalmology Shaanxi Provincial People's HospitalXi'an 710068Shaanxi ProvinceChina Xi'an Huaxia Eye Hospital Xi'an 710061Shaanxi ProvinceChina

AIM:To investigate the effects of on ocular surface microbiota in patients who received intravitreal ***:Samples of ocular surface microbiota were obtained from 41 eyes of 41 patients who visited the Department of *** were separated for three *** A did not receive perioperative managements or intravitreal *** B1 received only once and B2 received more than *** operating room,the samples were collected on the ocular *** taxonomic units(OTUs) clustering and alpha/beta diversity analysis was *** microbial 16S rRNA from samples were analyzed using the Hi Seq 2500 ***:Alpha diversity did not differ in each group,and beta diversity differed in the B2 *** diversity showed a significant difference between Group A and B2(P=0.048).With the perioperative managements before intravitreal injection,the composition and relative abundance were *** 10 microbiota on phylum and genus level,and then microbiota notably changed at genus level were ***-negative bacteria were varied ***,Proteus was not found in Groups A and B1,but it was appeared after the patients received perioperative management and intravitreal injections in Group ***:With the perioperative managements,the balance of microbiota on the ocular surface is destroyed,and relative composition and abundance of microbiota on the ocular surface is obviously *** clinical doctors should pay more attention on the consequence of perioperative managements before intravitreal injection.

关键词： microbiota perioperative managements ocular surface intravitreal injection high-throughput sequencing

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The ocular toxicity and pharmacokinetics of simvastatin following intravitreal injection in mice

引用

International Journal of Ophthalmology(English edition) 2017年第9期10卷 1361-1369页

作者： Dennis Y.Tse Seong Jae Kim Inyoung Chung Feng He Theodore G.Wensel Samuel M.Wu Department of Ophthalmology Baylor College of MedicineHoustonTX 77030USA School of Optometry the Hong Kong Polytechnic UniversityHong KongChina Department of Ophthalmology Institute of Health SciencesCollege of MedicineGyeongsang National UniversityJinju52727Korea Department of Biochemistry and Molecular Biology BaylorCollege of MedicineHoustonTX 77030USA

AIM：To investigate the retinal toxicity and pharmacokinetics of simvastatin intravitreally injected into ***：Forty-eight 6-8-week-old C57BL/6J mice were used in this *** was intravitreally injected into the right eye of each mouse;the left eye was injected with vehicle and was used as a *** dark-adapted electroretinography（ERG）was performed 1 and 7d following *** was examined using a combination of light,fluorescence and electron *** liquid chromatography（HPLC）was used to determine the decay in the retinal simvastatin ***：ERG revealed no significant changes in the simvastatin-injected eyes compared to *** studies showed normal retinal morphology in eyes injected with simvastatin up to a final vitreal concentration of 200μmol/*** significant changes in the number of photoreceptors,bipolar cells or ganglion cells were *** retinal simvastatin concentration decayed exponentially,with a half-life of ***：intravitreal injection of up to 200μmol/L simvastatin produced no signs of adverse effects in the mouse *** reaches the retina shortly after intravitreal injectionand has a short half-life.

关键词： simvastatin retina electroretinography highperformance liquid chromatography electron microscopy intravitreal injection

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Immediate intraocular pressure rise after intravitreal injection of ranibizumab and two doses of triamcinolone acetonide

引用

International Journal of Ophthalmology(English edition) 2011年第4期4卷 402-405页

作者： Gul Arikan Ali Osman Saatci Ferit Hakan Oner Department of Ophthalmology School of Medicine Dokuz Eylul University

AIM: To evaluate prospectively immediate intraocular pressure (IOP) changes after the intravitreal injection of ranibizumab, 2 and 4mg triamcinolone acetonide. METHODS: Patients who underwent intravitreal injection of 0.1mL (4mg) triamcinolone acetonide (TA, Group T4), 0.05mL (2mg) TA (Group T2) and 0.05mL (0.5mg) ranibizumab (Group R) comprised the study population. Overall, 229 eyes of 205 patients were injected. Fifty-four eyes (23.6%) were in Group T4, 69 eyes (30.1%) in Group T2 and 106 eyes (46.3%) in Group R. If IOP was less than 26mmHg immediately after the injection no further measurement was performed. If IOP was ≥26mmHg, IOP was remeasured till the reading was below 26mmHg at 5, 15 and 30 minutes. RESULTS: Immediately after the injection, the IOP of 28 eyes (51.9%) in Group T4, 22 eyes (31.9%) in Group T2 and 51 eyes (48.1%) in Group R were over 25mmHg. At 30 minutes, IOP of one eye (1.9%) in group T4, two eyes (2.9%) in group T2 and two eyes (1.9 %) in Group R were over 25mmHg. Immediate post-injection IOP was significantly higher in Group T4 and Group R when compared to Group T2 (P intravitreal injection of 2 or 4mg triamcinolone acetonide, and 0.5mg ranibizumab. Absence of vitreous reflux is the most important predicting factor for immediate IOP rise after the injection.

关键词： anti-VEGF agents glaucoma intraocular pressure intravitreal injection steroids

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Short-term fluctuation of intraocular pressure and influencing factors following intravitreal injection in patients with retinal vascular diseases

引用

International Journal of Ophthalmology(English edition) 2024年第11期17卷 2052-2059页

作者： Jing-Peng Miao Yi-Yun Zeng Xin-Ming Gu Xin-Yuan Zhang Beijing Tongren Eye Center Beijing Tongren HospitalCapital Medical UniversityBeijing Institute of OphthalmologyBeijing Key Laboratory of Institute of Ophthalmology and Visual SciencesBeijing 100730China

AIM:To investigate the patterns of short-term intraocular pressure(IOP)fluctuations and identify the contributing factors following intravitreal injection in patients with retinal vascular ***:Totally 81 patients were enrolled in this case control *** were categorized into 7 groups,including age-related macular degeneration(AMD),polypoidal choroidal vasculopathy(PCV),idiopathic choroidal neovascularization(CNV),proliferative diabetic retinopathy(PDR),diabetic macular edema(DME),macular edema secondary to branch(BVOME)and central(CVOME)retinal vein *** was measured in all patients using rebound tonometer at 7 preset time points ***,based on the administered medication,the eyes were classified into three treatment groups,including dexamethasone intravitreal implant(IVO),intravitreal conbercept(IVC),and intravitreal ranibizumab(IVR).To compare IOP values at various time points across groups,we employed one-way ANOVA,independent sample t-test or χ^(2) test and multivariate logistic regression ***:Peak IOP values across all groups were observed at 40s,and 5min after intravitreal *** differences in IOP were detected at the 5min among the 7 indication groups(F=2.50,P=0.029).When examing the impact of medications,the IVO group exhibited lower average IOP values at both 40s and 5min compared to the IVC and IVR groups(Pintravitreal *** administering intravitreal injection to patients with central retinal vein occlusion,it is essential

关键词： intravitreal injection rebound tonometer intraocular pressure retinal vein occlusion ocular fundus diseases

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Efficacy of intravitreal injection of ranibizumab in the treatment of macular edema secondary to non-ischemic branch retinal vein occlusion

引用

Journal of Hainan Medical University 2020年第2期26卷 46-50页

作者： Jue Liu Zai-Hong Chen Chongqing University Center Hospital Chongqing Emergency Medical Center Chongqing Fourth People's Hospital Ophthalmology Chongqing 400014 China

Objective: To observe the efficacy of intravitreal injection of ranibizumab in the treatment of macular edema(ME) secondary to non-ischemic branch retinal vein occlusion (BRVO). Methods: The clinical data of 27 patients (27 eyes) with macular edema secondary to non-ischemic BRVO were diagnosed by ophthalmology in Chongqing University Center Hospital from May 2018 to April 2019, selected as the experimental group, and 20 cases (20 eyes) of normal people as the control group. For the experimental group, before and after treatment, 1wk, 1mo, 2mo, 3mo and 6mo were used to observe the uncorrected visual acuity(UCVA),best corrected visual acuity (BCVA), intraocular pressure (IOP), central retinal thickness (CRT) macular center volume (MCV) and EN FACE images. Subjects in the normal control group were examined by optical coherence tomography (OCT) for CRT and CMV at 1wk, 1mo, 2mo, 3mo and 6mo on the day of and after enrollment. Results: The mean age of patients in the experimental group was (67.37±8.63) years old and the times of intravitreal injection was (3.26 ±0.59) times. The successful rate of treatment was 85.19%. There was no significant difference in IOP between pre-treatment and 1wk, 1mo, 2mo, 3mo and 6mo (P > 0.05). 1wk, 1mo, 2mo, 3mo and 6mo BCVA were significantly higher than those before treatment (P 0.05). EN FACE showed that 1wk, 1mo, 2mo, 3mo and 6mo macular thickness decreased gradually, retinal edema subsided, cystoid changes disappeared, and the interlamellar structure of the ellipsoid zone gradually recovered after intravitreal injectio

关键词： intravitreal injection ranibizumab branch retinal vein occlusion macular edema

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Study of the Influence of Angiostatin intravitreal injection on Vascular Leakage in Retina and Iris of the Experimental Diabetic Rats

引用

眼科学报 2006年第4期22卷 252-258页

作者： Jing Sima Jianxing Ma Sarah X.Zhang Jiang Guo Department of Ophthalmology Shenzhen 2nd Peoples Hospital Shenzhen 518035 Department of Medicine Department of Cell Biology The University of Oklahoma Health Science Center Oklahoma City OK 73104 USA.

Purpose: To examine the effect of an intravitreal injection of angiostatin on vascular leakage in retina and iris of the diabetes and study its possible mechanism. Methods: Experimental diabetes was induced in 24 rats by an intravenous injection of streptozotocin (STZ) during 48 adult rats. Three groups were randomization distributed of them. There were 8 of both normal and diabetic rats in each group. STZ-diabetic rats and age-matched normal rats received an intravitreal injection of 5 μl of sterile PBS (Phosphate Buffered Saline) into the right eye, and the left eye was non-injected in the group A; Angiostatin was injected into the vitreous of the right eye (7.5 μg / 5 μl / eye), and the left eye received the same volume of sterile PBS as the control in the group B and C. The vascular permeability of retina and iris was measured using the Evans blue method at 2 days following the injection in the group A and B. Expression of VEGF in retina was evaluated using western blot analysis 24 hours following the injection in the group C. Results: Diabetic rats showed significant increases of vascular permeability in the retina ( P intravitreal injection of the same dose of angiostatin into the age-matched normal rats did not result in any significant reduction in vascular permeability in the retina and iris, when compared with the contralateral eye with PBS injection ( P > 0.05). Angiostatin injection significantly reduced VEGF level in the retinas of STZ-diabetic rats but did not affect retinal VEGF level in normal rats. Conclusions: Angiostatin significantly reduce pathological vascular permeability in the retina and iris of STZ-diabetic rats but not in normal rats. Angiostatin down-regulates VEGF expression and thus, blocks the major cause of va

关键词： Angiostatin Angiogenic inhibitor Diabetic retinopathy Vascular endothelial growth factor intravitreal injection

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：