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intravesical instillation in Pure Line LEW Rats and Nude Mice

Journal of Huazhong University of Science and Technology(Medical Sciences) 2007年第3期27卷 288-290页

作者：周洁谢蜀生郭晓云莫曾南 Department of Urology the First Affiliated Hospital of Guangxi Medical University The Laboratory of Immunopharmacology Health Science Center Peking University Department of Gastroenterology the First Affiliated Hospital of Guangxi Medical University Department of Urology 3Department of Gastroenterology the First Affiliated Hospital of Guangxi Medical University

In order to study bladder intravesical instillation methods in pure line LEW rats and nude mice, female LEW rats and nude mice aged 2 to 4 weeks were sacrificed. Their urethra and bladder were observed under anatomical microscopy. A trochar was prepared according to the outline and an- gle of the urethra. Ink was poured into female rats and nude mice bladder though urethra. Filling and staining of bladder were observed and evaluated under anatomical microscopy. Status and urethral injury of rats and mice were observed. The results showed that urethra anatomic structure of rats and nude mice was different from that of human urethra. When bladder was filled with ink and became blue, liquid was not seen to leak out. The success rate of intubation was high (100%). Living activi- ties of animals weren’t influenced by intravesical instillation. It was concluded that bladder irrigation might be a kind of valid and utilizable method in pure line rat and nude mouse empirical study. The model may be a more effective tool for study of bladder tumor.

关键词： intravesical instillation bladder neoplasms animal model nude mouse

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Pilot study of intravesical instillation of two new generation anthracycline antibiotics in prevention of superficial bladder cancer recurrence

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Chinese Medical Journal 2010年第23期123卷 3422-3426页

作者： CHEN Si-yang DU Lin-dong ZHANG Yu-hai Department of Urology Beijing Friendship Hospital CapitalMedical University Beijing 100050 China

Background Superficial bladder cancer accounts for 60%-70% of all bladder cancer cases in China, when treatment consists of only transurethral resection of the bladder tumor （TUR-BT）, recurrence and progresses in the bladder are observed in some patients. There are numerous reports of trials of intravesical instillation of anticancer agents with the objective of lowering this recurrence rate. The aim of this study was to compare the prophylactic efficacy and safety of epirubicin （EPI）, pirarubicin （THP） and hydroxycamptothecin （HCPT） in superficial bladder *** This study enrolled a total of 189 patients who had been diagnosed with superficial bladder cancer during the period from 2004 through 2007 at Beijing Friendship Hospital. All patients were randomly allocated to one of three treatment groups. Patients in group A received 29 doses of EPI 30 mg/30 ml, patients in group B received 29 doses of THP 30 mg/30 ml, and patients in group C received 29 doses of HCPT 30 mg/30 ml, over a period of 24 *** The recurrence-free rate in the 2 anthracycline treatment groups （A and B） were significantly better than that of the HCPT treatment group. In the safety evaluation, the incidences of pollakiuria, pain on urination, dysuria, hematuria,and contracted bladder were not significantly different between groups A and B, but some were significantly higher in groups A and B than that in group *** The efficacy of EPI and THP was significantly better than HCPT in the prevention of bladder cancer recurrence.

关键词： epirubicin pirarubicin hydroxycamptothecin superficial bladder cancer intravesical instillation

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intravesical instillation of sodium hyaluronate for the treatment of non muscle-invasive bladder neoplasms after transurethral resection

Intravesical instillation of sodium hyaluronate for the trea...

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2014浙江省医学会男科学泌尿外科学学术年会

作者： Yang Jian-hui Ren Yu Zhang Shu-wei Xie zhen-hua Department of Urology Ningbo Yinzhou No.2 Hospital

Objective:To discuss the efficacy of intravesical instillation of sodium hyaluronate for the treatment of non muscle-invasive bladder neoplasms after transurethral ***:23 patients(7male and 16 female,age range 52-78 years,mean age 63.5) who were diagnosed as Non muscle-invasive Bladder neoplasms underwent transurethral *** the operation they were instill with epirubicin firstly,then with sodium hyaluronate after urinate once a week for four weeks,and then once a month for four *** clinical symptom score was used to evaluate the symptom..Results:During the treatment of 23 cases of patients with stable vital *** scores of OABSSclinical symptom、frequency of micturition in day、frequency of micturition in night、urgency、Urge incontinence before therapy were(13.04±0.98)、(1.82 ±0.39)、(2.83 ±0.39)、(4.48±0.51)、(3.86 ± 0.56).The scores of OABSSclinical symptom、frequency of micturition in day、frequency of micturition in night、urgency、Urge incontinence before therapy were 5.00 ± 3.29、0.65 ± 0.57、2.10 ± 0.80、1.91 ± 1.20、1.27 ± *** was significant difference(P intravesical sodium hyaluronate therapy can effectively decline the recurrence rate of non muscle-invasive bladder neoplasms after transurethral *** could also significantly improve the urinary tract symptoms.

关键词： Sodium hyaluronate intravesical instillation non muscle-invasive bladder neoplasms

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Impact of surgery and epirubicin intravesical chemotherapy on peripheral blood dendritic cell subsets in patients with superficial urothelial carcinoma of the bladder

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Chinese Medical Journal 2012年第7期125卷 1254-1260页

作者： FENG Lang MA Lin-lin ZHANG Yu-hai TIAN Ye QU Chen-xue WANG Yang Department of Urology Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China Department of Laboratory Center Tongren HospitalCapital Medical UniversityBeijing 100730

Background Superficial urothelial carcinoma （SUC） of the bladder is a common urinary tract tumor in China. There is a high recurrence rate of this tumor even after surgery and intravesical instillation. Previous reports have described a suppression of the immune system in cancer patients. Dendritic cells （DCs） play a pivotal role in the induction of an effective antitumor immune response. The aim of this study was to investigate the effects of surgery and epirubicin intravesical chemotherapy （IC） on peripheral blood DCs in subsets of patients with bladder SUC. Methods A total of 66 SUC patients and 38 healthy controls were enrolled in this study. All the patients had undergone transurethral resection （TUR） of their cancer and adjunctive IC after tumor removal. The patients were divided into a non-recurrence group （n=40） and a recurrence group （n=26） based on the presence or absence of tumor recurrence. Blood samples were taken preoperatively （PreOP）, on postoperative days （POD） 1 and 7, and at postoperative month （POM） 3. Flow cytometric analysis was used for the determination and quantitation of the surface markers CD80 and CD86 in circulating DC subsets. Results The preoperative percentages of myeloid dendritic cells （mDCs） and expression of CD80 and CD86 were impaired in SUC patients compared to healthy controls （P 〈0.05）. The percentages of mDCs and these surface markers decreased significantly on POD 1 and increased on POD 7, remaining higher than the preoperative values in POM 3 （P 〈0.05）. The percentages of mDCs, and CD80 and CD86 in the non-recurrence group on PreOP, POD 7, and POM 3 were higher than those in recurrence group. Conclusions Surgical removal of SUC and adjunctive IC were associated with improved circulating mDC counts and function. Persistent depression of mDC counts and function after treatment in recurrence patients indicated lower antitumor immunity that may lead to tumor recurrence.

关键词： dendritic cells urothelial carcinoma of bladder intravesical instillation recurrence

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