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Study on the Cellular Molecular Mechanism of intrauterine transmission of Hepatitis B Virus

Journal of Nanjing Medical University 2003年第5期17卷 243-248页

作者：王健孙琳 DepartmentofAetiologyandImmunology MedicalCollegeAnhuiUniversityofScienceandTechnologyHuainan232001 ~DepartmentofObstetricsandGynecology StaffandWorkersHospitalofGeneralChemicalPlantofHuainanHuainan232038P.R.China

Objective: To study intrauterine transmission of HBV and its cellular molecular mechanism and influence on the fetus. Methods.. A total of 46 coses of pregnant women who suffered from HBV were divided into HBeAg ( + ) and HBeAg ( -) groups. HBV-DNA in serum and peripheral blood mononuclear cells (PBMC-) of 46 cases of pregnant women before delivery was detected by polymerase chain reaction (PCR). After placenta being delivery, HBV-DNA in serum and cord blood mononuclear cells (CBMC) was also detected by PCR. Results.. The total of positive rates of HBV-DNA in serum and PBMC of pregnant women with hepatitis B were 69. 57% (32/46) and 41. 30% (19/46). The positive rates of HBV-DNA in serum of cord blood and CBMC were 56. 52%(26/46) and 21. 74% (10/46) respectively. Among them, the positive rates of HBV-DNA in serum and PBMC of pregnant women with HBeAg ( + ) were 100. 00% (25/25) and 60. 00% (15/25) respectively. The positive rates of HBV-DNA in serum of cord blood and CBMC were 88. 00% (22/25) and 32. 00% (8/25) respectively. The positive rates of HBV-DNA in serum and PBMC of pregnant women with HBeAg (-) were 33. 33% (7/21) and 19.05% (4/21) respectively. The positive rates of HBV-DNA in serum of cord blood and CBMC were 19. 05%(4/21) and 9. 52% (2/21) respectively. The positive rates of HBV-DNA in serum of cord blood and CBMC of newborns were higher in the group of pregnant women with HBeAg ( + ) than those in the group of pregnant women with HBeAg ( -) (Pintrauterine transmission of HBV can be existent and its transmission way not only can be induced by serum but also can be induced by PBMC. The way of intrauterine transmission of HBV induced by PBMC was concealed. The dangerous possibility of intrauterine transmission is higher in the pregnant women with HBeAg (+) than that in the group of pregnant women with HBeAg ( -).

关键词： hepatitis B intrauterine transmission pregnant woman newborn pe-ripheral blood mononuclear cells cord blood mononuclear cells

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Relationship between heterogeneity of HBV preS/S gene and intrauter-ine transmission

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Journal of Medical Colleges of PLA(China) 2002年第2期17卷 112-115页

作者：李端闫永平徐德忠张景霞 Department of Epidemiology Faculty of Preventive Medicine Fourth Military Medical University Xi'an 710033 China

Objective: To study the relationship of the mutation of HBV preS/S gene in HBsAg carrying pregnant women and intrauterine transmission. Methods: Polymerase chain reaction (PCR) was used to amplify HBV preS/S gene from sera of 8 HBsAg carrying pregnant women, 4 women's neonates infected with HBV, and the other's neonates non-infected with. The PCR products were cloned and 5 clones were chosen from every woman for DNA sequencing. Results: Heterogeneity of HBV preS/S gene in HBsAg carrying pregnant women having intrauterine transmission was much higher than that from having not intrauterine transmission, and the divergence rate of nucleotide sequences also higher strikingly. Conclusion: High heterogeneity of HBV preS/S gene of HBsAg positive pregnant women may be relative to high rate of intrauterine transmis-sion

关键词： hepatitis B virus preS/S gene intrauterine transmission variation

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