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Bimatoprost/timolol fixed combination(BTFC) in patients with primary open angle glaucoma or ocular hypertension in Greece

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International Journal of Ophthalmology(English edition) 2016年第1期9卷 69-75页

作者： Tryfon G.Rotsos Vasso G.Kliafa Kevin J.Asher Dimitrios Papaconstantinou 1st Department of Ophthalmology University of Athens Department of Regulatory Affairs Nexus Medicals S.A. Department of Regional Scientific Services Allergan Holdings Limited

AIM：To evaluate the efficacy and tolerability of the fixed combination of bimatoprost 0.03%and timolol 0.5%（BTFC）in patients in Greece with primary open angle glaucoma（POAG）or ocular hypertension（OHT）whose previous therapy provided insufficient lowering of intraocular pressure（IOP）.·METHODS：A multicenter,prospective,open-label,non-interventional,observational study of the use of BTFC in clinical practice was conducted at 41 sites in Greece.The primary endpoint was the reduction in IOP from baseline at study end,approximately 12wk after initiation of BTFC therapy.·RESULTS：A total of 785 eligible patients were enrolled in the study and 97.6%completed the study.The mean±SD IOP reduction from baseline at 12wk after initiation of BTFC was 6.3±2.8 mm Hg（=764;〈0.001）.In patients（=680）who replaced their previous IOP-lowering monotherapy（a single drug,or a fixed combination of 2drugs in a single ophthalmic drop）with once-daily BTFC,the mean±SD IOP reduction from baseline at 12wk was 6.2±2.8 mm Hg（〈0.001）.IOP was reduced from baseline in 99.2%of patients,and 58.0%of patients reached or exceeded their target IOP.Substantial mean IOP reductions were observed regardless of the previous therapy.BTFC was well tolerated,with 96.0%of patients who completed the study rating the tolerability of BTFC as＂good＂or＂very good.＂Adverse events were reported in 8.3%of patients;only 0.6%of patients discontinued the study due to adverse events.·C ONCLUSION：In clinical practice in Greece,BTFC is well tolerated and effectively lower the IOP in patients with POAG or OHT who requires additional IOP lowering on their previous therapy.

关键词： fixed combination glaucoma intraocularpressure ocular hypertension primary open angle glaucoma prostaglandin prostamide timolol

Viscocanalostomy combined with trabeculotomy and mitomycin C in the treatment of primary congenital glaucoma

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International Journal of Ophthalmology(English edition) 2017年第6期10卷 919-924页

作者： Chao-Xu Qian Yuan Zong Qin Chen Zhi-Lan Yuan Department of Ophthalmology the Third People’s Hospital of Changzhou Department of Ophthalmology EyeEarNose & Throat Hospital of Fudan University Department of Ophthalmology the First Affiliated Hospital of Nanjing Medical University

AIM： To evaluate the long-term outcome of viscocanalostomy combined with trabeculotomy and mitomycin C in the treatment of primary congenital glaucoma. METHODS： This is a retrospective study. Forty-two eyes of 26 patients with primary congenital glaucoma were enrolled, Intraocular pressure （lOP）, corneal diameter （mm） and cup/disc （C/D） were measured before and after the surgery respectively. Follow-up period was 30mo. RESULTS： The mean preoperative lOP was 30.6：1：7.35 mm Hg. Of the 42 eyes, 2 eyes were required conversion to trabeculectomy for the absence of Schlemm＇s canal. Of remained 40 eyes, 38 eyes （95%） achieved successful lOP control. The average postoperative lOP was 11.69±4.18 mm Hg at 12mo. The mean reduction was 18.91 mm Hg （P〈0.00Ol）. Eighteen （75%） eyes presented a reduction in corneal diameter, and 25 （62.5%） eyes presented a C/D ratio reversal after the surgery. There was no serious complication in any patients over the follow-up period. CONCLUSION： Viscocanalostomy combined with trabeculotomy and mitomycin C is useful in the management of primary congenital glaucoma,

关键词： glaucoma treatment surgery intraocularpressure congenital eye disorders

Effect of phacoemulsification on intraocular pressure in patients with primary open angle glaucoma and pseudoexfoliation glaucoma

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International Journal of Ophthalmology(English edition) 2017年第9期10卷 1374-1378页

作者： Jesus Jimenez-Roman Gabriel Lazcano-Gomez Karina Martínez-Baez Mauricio Turati Rosario Gulías-Canizo Luis F.Hernández-Zimbrón Lenin Ochoa-De la Paz Rubén Zamora Roberto Gonzalez-Salinas Glaucoma Department Asociation to Prevent Blindness inMexicoMexico City 04030Mexico Research Department Asociation to Prevent Blindness inMexicoMexico City 04030Mexico Cell Biology Department Advanced Research CenterI.P.N.(CINVESTAV)in Mexico CityMexico City 07360Mexico

AIM：To compare the effect of phacoemulsification on intraocular pressure（IOP）in patients with primary open angle glaucoma（POAG）and pseudoexfoliation glaucoma（PXG）.METHODS：A retrospective comparative case series conducted at the Glaucoma Department at the Association to Prevent Blindness in Mexico.The study enrolled consecutive patients having phacoemulsification with intraocular lens（IOL）implantation and a diagnosis of POAG or PXG.Data about IOP values and number of glaucoma medications used was collected at baseline,1,3,6 and12mo postoperatively.RESULTS：The study enrolled 88 patients（88 eyes）.After phacoemulsification,there was a statistically significant reduction in IOP values and glaucoma medications use compared to baseline in both POAG and PXG patients（P〈0.001）.In the POAG group,a 20%decrease in IOP values was evidenced,and a 56.5%reduction in the number of medications used at the one-year follow-up.The PXG group showed a 20.39%,and a 34.46%decrease in IOP and number of medications used,respectively.A significant difference in the meanΔIOP（postoperative changes in IOP）was evidenced between groups（P=0.005）.The reduction of the postsurgical IOP mean values in both groups,the POAG group showed a greater reduction in IOP values compared to the PXG group.CONCLUSION：In both types of glaucoma,phacoemulsification cataract surgery can result in a significant IOP reduction（20%）over a 12mo follow-up period.The number of medications used is also significantly reduced up to 12mo after surgery,especially in the PXG group.

关键词： cataract surgery pseudoexfoliation glaucoma secondary glaucoma primary open angle glaucoma intraocularpressure

Comparison of ICare and IOPen vs Goldmann applanation tonometry according to international standards 8612 in glaucoma patients

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International Journal of Ophthalmology(English edition) 2016年第11期9卷 1624-1628页

作者： Milena Pahlitzsch Jeanette Brünner Johannes Gonnermann Anna-Karina B.Maier Necip Torun Eckart Bertelmann Matthias KJ.Klamann Glaucoma and Retinal Degeneration Research Group UCLInstitute of Ophthalmology Department of Ophthalmology Campus Virchow ClinicCharite University MedicineAugustenburger Platz 1

AIM： To compare IOPen and ICare rebound tonometry to Goldmann applanation tonometry（GAT） according to International Standards Organization（ISO） 8612 criteria.METHODS： Totally 191 eyes（n =107 individuals） were included. Criteria of ISO 8612 were fulfilled： 3 clusters of IOP, measured by GAT, were formed. The GAT results were given as mean±standard deviation.RESULTS： GAT（19.7±0.5 mm Hg） showed a significant correlation to ICare（19.8±0.5 mm Hg）（r =0.547, P 〈0.001）and IOPen（19.5 ±0.5 mm Hg）（r =0.526, P 〈0.001）.According to ISO 8612 criteria in all 3 IOP groups the number of outliers（of the 95% limits of agreement）exceeded 5% for ICare and IOPen vs GAT： No.1（n =68）29.4% and 22.1%, No.2（n =62） 35.5% and 37.1%, No.3（n =61） 26.2% and 42.6%, respectively.CONCLUSION： The strict requirements of the ISO 8612 are not fulfilled in a glaucoma collective by ICare and IOPen at present. As long as the Goldmann tonometry is applicable it should be used first of all for reproducible IOP readings. ICare and IOPen tonometry should be considered as an alternative tool, if application of Goldmann tonometry is not possible.

关键词： ICare tonometry IOPen tonometry Goldmann applanation tonometry glaucoma intraocularpressure