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A systematic strategy for screening therapeutic constituents of Schisandra chinensis(Turcz.) Baill infiltrated blood-brain barrier oriented in lesions using ethanol and water extracts:a novel perspective for exploring chemical material basis of herb medicines

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Acta Pharmaceutica Sinica B 2020年第3期10卷 557-568页

作者： Yiwen Zhang Xinyan Lv Jiameng Qu Xin Zhang Mingyang Zhang Hao Gao Qian Zhang Ran Liu Huarong Xu Qing Li Kaishun Bi School of Pharmacy Shenyang Pharmaceutical University Shenyang 110016China School of Traditional Chinese Materia Medica Shenyang Pharmaceutical UniversityShenyang 110016China

Schisandra chinensis,a widely used Chinese herbal medicine,was considered as central nervous system(CNS)drug for years.Both ethanol extracts(EES)and water extracts(WES)of it were applied clinically.Unfortunately,the difference of their efficacy and even effective material foundation of S.chinensis remains obscure.In this study,to explore the active constituents of S.chinensis,we compared pharmacodynamics and chemical profiles in vitrolin vivo of EES/WES for the first time using multiple chemical analysis,pharmacological and data processing approaches.It was proved that there was no significant difference in the anti-depressive effects between WES and EES.However,the contents of most components in vitro and in plasma were higher in EES than those in WES,which was unconvincing for their similar efficacy.Therefore,we further explored components of S.chinensis targeted onto brain and the results showed that 5 lignans were identified with definite absorptivity respectively both in EES and WES caused by the limitation of blood-brain barrier.Moreover,bioinformatic analysis predicted their anti-depressive action.Above all,the systematic strategy screened 5 brain-targeted effective substances of S.chinensis and it was suggested that exploring the components into nidi would promote the studies on herbs effective material basis.

关键词： Schisandra chinensis Ethanol extracts Water extracts Pharmacodynamics Chemical profiles Components into nidi Effective material basis Traditional Chinese medicine

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Monitoring maturation of neural stem cell grafts within a host microenvironment

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World Journal of Stem Cells 2019年第11期11卷 982-989页

作者： Olga Kopach Department of Clinical and Experimental Epilepsy Queen Square Institute of Neurology University College London

Neural stem cells(NSC)act as a versatile tool for neuronal cell replacement strategies to treat neurodegenerative disorders in which functional neurorestorative mechanisms are limited.While the beneficial effects of such cellbased therapy have already been documented in terms of neurodegeneration of various origins,a neurophysiological basis for improvement in the recovery of neurological function is still not completely understood.This overview briefly describes the cumulative evidence from electrophysiological studies of NSCderived neurons,aimed at establishing the maturation of differentiated neurons within a host microenvironment,and their integration into the host circuits,with a particular focus on the neurogenesis of NSC grafts within the post-ischemic milieu.Overwhelming evidence demonstrates that the host microenvironment largely regulates the lineage of NSC grafts.This regulatory role,as yet underestimated,raises possibilities for the favoured maturation of a subset of neural phenotypes in order to gain timely remodelling of the impaired brain tissue and amplify the therapeutic effects of NSC-based therapy for recovery of neurological function.

关键词： Neural stem cells Embryonic progenitors Neurogenesis Maturation of neurophysiological properties Integration into network Neural stem cell therapy Neurodegeneration Ischemic injury

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Molecular Mechanism of the Specificity of Protein Import into Chloroplasts and Mitochondria in Plant Cells

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Molecular Plant 2019年第7期12卷 951-966页

作者： Dong Wook Lee Sumin Lee Junho Lee Seungjin Woo Md.Abdur Razzak Alessandro Vitale Inhwan Hwang Division of Integrative Biosciences and Biotechnology Pohang University of Science and Technology Pohang 37673 Korea Department of Life Sciences Pohang University of Science and Technology Pohang 37673 Korea Istituto di Biologia e Biotecnologia Agraria Consiglio Nazionale Delle Ricerche Milano Italy

Plants possess both types of endosymbiotic organelles, chloroplasts and mitochondria. Transit peptides and presequences function as signal sequences for specific import into chloroplasts and mitochondria, respectively. However, how these highly similar signal sequences confer the protein import specificity remains elusive. Here, we show that mitochondrial- or chloroplast-specific import involves two distinct steps, specificity determination and translocation across envelopes, which are mediated by the N-terminal regions and functionally interchangeable C-terminal regions, respectively, of transit peptides and presequences. A domain harboring multiple-arginine and hydrophobic sequence motifs in the N-terminal regions of presequences was identified as the mitochondrial specificity factor. The presence of this domain and the absence of arginine residues in the N-terminal regions of otherwise common targeting signals confers specificity of protein import into mitochondria and chloroplasts, respectively. AtToc159, a chloroplast import receptor, also contributes to determining chloroplast import specificity. We propose that common ancestral sequences were functionalized into mitochondrial- and chloroplast-specific signal sequences by the presence and absence, respectively, of multiple-arginine and hydrophobic sequence motifs in the N-terminal region.

关键词： transit peptide presequence protein import into chloroplasts and mitochondria N-terminal specificity domain C-terminal common translocation domain import specificity determination

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Carbon and Nitrogen Amendments Lead to Differential Growth of Bacterial and Fungal Communities in a High-pH Soil

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Pedosphere 2018年第2期28卷 255-260页

作者： Pramod N. KAMBLE Erland BAATH Microbial Ecology Department of Biology Ecology Building Lund University Lund SE-223 62 (Sweden) Department of Environmental Sciences Savitribai Phule Pune University Pune 411007 (India)

Microbial growth in soil is mostly limited by lack of carbon (C). However, adding fresh, C-rich litter can induce nitrogen (N) limitation. We studied the effect of alleviating C and N limitation in high-pH (> 8) soils, soils expected to favor bacterial over fungal growth. Nitrogen limitation was induced by incubating soils amended with C-rich substrate (starch or straw) for 4 weeks. Limiting nutrients and the effects of alleviating limitation were then studied by adding C (as glucose) or N (as NH_4NO_3) and measuring microbial growth and respiration after 4 d. In non-amended, C-limited soils, adding C but not N increased both microbial respiration and bacterial growth. In N-limited, substrate-amended soils, adding C increased respiration, whereas adding N increased both microbial respiration and growth. Inducing N limitation by amending with straw was most easily detected in increased fungal growth after the addition of N, whereas with starch, only bacterial growth responded to alleviating N limitation. Compared to earlier results using a low-pH soil, the effect of substrate used to induce N limitation was more important than pH for inducing bacterial or fungal growth after alleviating N limitation. Furthermore, we found no evidence that alleviating N limitation resulted in decreased respiration concomitant with increased microbial growth in soil, suggesting no drastic changes in C use efficiency.

关键词： acetate incorporation into ergosterol carbon use efficiency leucine incorporation limiting nutrient microbial growth microbial respiration N limitation

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Theoretical Investigation of Influence of Mechanical Stress on Magnetic Properties of Ferromagnetic/Antiferromagnetic Bilayers Deposited on Flexible Substrates

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Chinese Physics Letters 2016年第8期33卷 118-122页

作者：白宇浩王霞穆林平许小红 College of Physics and Electronic Information Shanxi Normal University School of Chemistry and Materials Science Key Laboratory of Magnetic Molecules and Magnetic Information Materials(Ministry of Education)Shanxi Normal University

Effect of mechanical stress on magnetic properties of an exchange-biased ferromagnetic/antiferromagnetic bilayer deposited on a flexible substrate is investigated. The hysteresis loops with different magnitudes and orientations of the stress can be classified into three types. The corresponding physical conditions for each type of the loop are deduced based on the principle of minimal energy. The equation of the critical stress is derived, which can judge whether the loops show hysteresis or not. Numerical calculations suggest that except for the magnitude of the mechanical stress, the relative orientation of the stress is also an important factor to tune the exchange bias effect.

关键词： of for Theoretical Investigation of Influence of Mechanical Stress on Magnetic Properties of Ferromagnetic/Antiferromagnetic Bilayers Deposited on Flexible Substrates is been on from that into

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The assessment of time dependent flow of Williamson fluid with radiative blood flow against a wedge

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Propulsion and Power Research 2020年第1期9卷 87-99页

作者： K.Subbarayudu S.Suneetha P.Bala Anki Reddy Department of Applied Mathematics Yogi Vemana UniversityKadapa516005India Department of Mathematics S.A.S.Vellore Institute of TechnologyVellore632014India

The present pagination reports both Brownian diffusion and thermophoresis aspects subject to magneto hydrodynamic Williamson fluid model.Assuming the flow is unsteady and blood is treated as Williamson fluid over a wedge with radiation.The governing equations are transformed into ordinary differential equations by using similarity variables.The analytical solutions of the transformed governing equations are obtained by using the RK 4th order method along with shooting technique solver.The effects of various physical parameters such as Hartmann number,local Weissenberg number,radiation parameter,unsteadiness parameter,Prandtl number,Lewis number,Brownian diffusion,thermophoresis,wedge angle parameter,moving wedge parameter,on velocity,temperature,concentration,skin friction,heat transfer rate and mass transfer rate have been discussed in detail.The velocity and temperature profile deprives for larger We and an opposite trend is observed for concentration.The radiation parameter is propositional to temperature and a counter behaviour is observed for Pr.

关键词： The present pagination reports both Brownian diffusion and thermophoresis aspects subject to magneto hydrodynamic Williamson fluid model. Assuming the flow is unsteady and blood is treated as Williamson fluid over a wedge with radiation. The governing equations are transformed into ordinary differential equations by using similarity variables. The analytical solutions of the transformed governing equations are obtained by using the RK 4th order method along with shooting technique solver. The effects of various physical parameters such as Hartmann number local Weissenberg number radiation parameter unsteadiness parameter Prandtl number Lewis number Brownian diffusion thermophoresis wedge angle parameter moving wedge parameter on velocity temperature concentration skin friction heat transfer rate and mass transfer rate have been discussed in detail. The velocity and temperature profile deprives for larger We and an opposite trend is observed for concentration. The radiation parameter is propositional to temperature and a counter behaviour is observed for Pr.

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Neuroregeneration using in vivo cellular reprogramming

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Neural Regeneration Research 2017年第7期12卷 1073-1074页

作者： Tu Nguyen Raymond Ching-Bong Wong Centre for Eye Research Australia East Melbourne VIC Australia Ophthalmology Department of Surgery University of MelbourneMelbourne VIC Australia

Cellular reprogramming is an innovative technology used to artificlally convert a mature cell type into a different cell type by molecular＇manipulation. The general concept of cellular reprogramming is to use master transcription factors to override the endogenous transcriptome profile of a given cell type with the transcriptome profile of the target cell type, thereby altering the cellular function and identity.

关键词： in on cell gene Neuroregeneration using in vivo cellular reprogramming into

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Complex Networks from Chaotic Time Series on Riemannian Manifold

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Chinese Physics Letters 2016年第10期33卷 28-31页

作者：孙建成 School of Software and Communication Engineering Jiangxi University of Finance and Economics

Complex networks are important paradigms for analyzing the complex systems as they allow understanding the structural properties of systems composed of different interacting entities. In this work we propose a reliable method for constructing complex networks from chaotic time series. We first estimate the covariance matrices, then a geodesic-based distance between the covariance matrices is introduced. Consequently the network can be constructed on a Riemannian manifold where the nodes and edges correspond to the covariance matrix and geodesic-based distance, respectively. The proposed method provides us with an intrinsic geometry viewpoint to understand the time series.

关键词： of is Complex Networks from Chaotic Time Series on Riemannian Manifold from into been on for that

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Numerical Evaluation of Effect of Motion of Samples on Ptychographic Imaging and Solution with a Random Phase Modulator

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Chinese Physics Letters 2016年第2期33卷 43-46页

作者：李昭慧张建奇刘德连王晓蕊 School of Physics and Optoelectronic Engineering Xidian University Collaborative Innovation Center of Information Sensing and Understanding Xidian University

The retrieval of ptychographical imaging encounters a degradation produced by motion of samples. The mech- anism of capturing the diffractive patterns of a sample which is motile is simulated numerically. The relation between the retrieval degradation and the amplitude of motion is evaluated quantitatively. Experiments indicate that the reliability and resolution of the complex amplitude retrieval of a sample is inversely proportional to its vibratory amplitude. A random phase modulated aperture is employed to cure the degradation produced by the motion of samples to a certain extent.

关键词： of et is with PIE RPM into that MSE on CCD

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Manipulating Backward Propagation of Acoustic Waves by a Periodical Structure

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Chinese Physics Letters 2016年第11期33卷 58-61页

作者：徐峥钱梦騄程茜刘晓峻 Institute of Acoustics Tongji University School of Physics Nanjing University

In the backward propagation of acoustic waves, the direction of phase velocity is anti-parallel to that of group velocity. We propose a scheme to manipulate the backward propagation using a periodicM structure. The dynamic backward propagation process is further experimentally observed. It is demonstrated that the oblique incident plane wave moves backward when it travels through the periodical structure and the backward shift can be controlled within a certain range.

关键词： of on as Manipulating Backward Propagation of Acoustic Waves by a Periodical Structure is by MHz into

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