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Early changes to the extracellular space in the hippocampus under simulated microgravity conditions

Science China(Life Sciences) 2022年第3期65卷 604-617页

作者： Yajuan Gao Hongbin Han Jichen Du Qingyuan He Yanxing Jia Junhao Yan Hui Dai Bin Cui Jing Yang Xunbin Wei Liu Yang Rui Wang Ren Long Qiushi Ren Xing Yang Jiabin Lu Department of Radiology Peking University Third HospitalBeijing 100191China Institute of Medical Technology Peking University Health Science CenterBeijing 100191China Beijing Key Laboratory of Magnetic Resonance Imaging Technology Beijing 100191China Department of Neurology Aerospace Center HospitalPeking University Aerospace Clinical CollegeBeijing 100039China State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking UniversityBeijing 100191China Department of Anatomy and Histology School of Basic Medical SciencesPeking UniversityBeijing 100191China NHC Key Laboratory of Medical Immunology Department of ImmunologySchool of Basic Medical SciencesPeking UniversityBeijing 100191China Department of Radiology Aerospace Center HospitalPeking University Aerospace Clinical CollegeBeijing 100039China

The smooth transportation of substances through the brain extracellular space(ECS)is crucial to maintaining brain function;however,the way this occurs under simulated microgravity remains *** this study,tracer-based magnetic resonance imaging(MRI)and DECS-mapping techniques were used to image the drainage of brain interstitial fluid(ISF)from the ECS of the hippocampus in a tail-suspended hindlimb-unloading rat model at day 3(HU-3)and 7(HU-7).The results indicated that drainage of the ISF was accelerated in the HU-3 group but slowed markedly in the HU-7 *** tortuosity of the ECS decreased in the HU-3 group but increased in the HU-7 group,while the volume fraction of the ECS increased in both *** diffusion rate within the ECS increased in the HU-3 group and decreased in the HU-7 *** alterations to ISF drainage and diffusion in the ECS were recoverable in the HU-3 group,but neither parameter was restored in the HU-7 *** findings suggest that early changes to the hippocampal ECS and ISF drainage under simulated microgravity can be detected by tracer-based MRI,providing a new perspective for studying microgravity-induced nano-scale structure abnormities and developing neuroprotective approaches involving the brain ECS.

关键词： brain extracellular space interstitial fluid interstitial system tracer-based magnetic resonance imaging simulated microgravity hindlimb-unloading

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