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Prenatal morphine exposure inhibits GABAA receptor-mediated responses in day-old chicks

Prenatal morphine exposure inhibits GABAA receptor-mediated ...

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中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Juan JIANG~1,Nan SUI~(1,*),Meng-Ya WANG~(2,*) 1 The Key Laboratory of Mental Health,Institute of Psychology,Chinese Academy of Sciences,Beijing 100101,China 2 Cell Electrophysiology Laboratory,Wannan Medical College,Wuhu 241002,China

Objective Prenatal morphine exposure may alter developmental process of fetal brain through activation of opioid receptors during the critical *** pervious work has shown that embryonic day 5-8(E5-8) may be the critical period to impair learning and memory functions in day-old chicks due to prenatal morphine exposure,which may be related to developmental changes of y-aminobutyric acid(GABA) *** this work,intracellular recording was used to investigate the effect of early prenatal morphine exposure on GABAergic system in day-old *** Coronal sections of left forebrains(500 )μm),containing the intermediate medial mesopallium(IMM) which is intimately involved in the early learning processes,were prepared from domestic chicks(0-12 days old),which were from control group(no treatment) or from saline group(treated by intra-allantoic injection of saline in E5-8) or from morphine group(treated by intra-allantoic injection of morphine in E5-8).Results(1) Spontaneous inhibitory postsynaptic potentials(sIPSPs) were observed in IMM neurons from all groups,but the occurrence rate of sIPSPs from morphine group(6.9%,4/58 cells) was obviously lower than control group(28.6%,14/49 cells) or saline group(32.1%,18/56 cells)(P<0.01).(2) The evoked excitatory or inhibitory postsynaptic potentials(eEPSPs or eIPSPs) were elicited by local electrical stimuli at 0.1 Hz in the IMM *** induction rate of elPSPs from morphine group(27.6%,16/58) was also lower than control group(49.0%, 24/49 cells) or saline group(48.2%,27/56 cells)(P<0.05),while the induction rate of eEPSPs was not significant in difference between morphine group and other groups.(3) Bath-applied bicuculline(5μM,a GABA receptor antagonist) enlarged the amplitude,area under curve and duration of *** bath of bicuculline,the duration of eEPSPs from morphine group(1.8±2.1s,n=11) were shorter than saline group(4.9±3.0s,n=8) or control group(4.8±3.0s,n=4)(P<0.05).(4) Muscimol (1 mM,a specific GA

关键词： chick early prenatal morphine exposure γ-aminobutyric acid intracellular recording intermediate medial mesopallium bicuculline muscimol synapse response

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