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Predicting value of serum soluble ST2 and interleukin-33 for risk stratification and prognosis in patients with acute myocardial infarction

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Chinese Medical Journal 2013年第19期126卷 3628-3631页

作者： ZHANG Kun ZHANG Xin-chao MI Yu-hong LIU Juan Department of Emergency Beijing Hospital Ministry of HealthBeijing 100730 China Department of Emergency Beijing Anzhen Hospital Capital MedicalUniversity Beijing 100029 China Department of Physiology and Pathophysiology Peking UniversityHealth Science Center Beijing 100191 China

Background Acute myocardial infarction （AMI） is a common cardiac emergency with high *** soluble ST2 （sST2） is a new emerging biomarker of cardiac *** present study is to investigate the predictive value of sST2 and interleukin-33 （IL-33） for risk stratification and prognosis in patients with *** Fifty-nine patients with AMI,whose chief complaint was chest pain or dyspnea,were selected for our *** examination,chest radiograph,electrocardiograph （ECG）,biomarkers of myocardial infarction,NT-proBNP,echocardiography and other relevant examinations were performed to confirm the diagnosis of ***-six healthy people were chosen as the control *** samples from these subjects （patients within 24 hours after acute attack） were collected and the levels of sST2 and IL-33 were assayed by enzyme-linked immuno-sorbent assay （ELISA） *** follow-up was performed on the 7th day,28th day,3rd month and 6th month after acute *** to the follow-up results we defined the end of observation as recurrence of AMI or any causes of *** Median sST2 level of the control group was 9.38ng/ml and that of AMI patients was 29.06ng/*** with the control group,sST2 expression in the AMI group was significantly different （P〈0.001）.In contrast,the IL-33 level showed no significant difference between the two *** sST2 was a predictive factor independent of other variables and may provide complementary information to NT-proBNP or GRACE risk ***-33 had no relationship to recurrence of *** sST2 and the IL-33/sST2 ratio were correlated with the 6-month prognosis; areas under the ROC curve were 0.938 and 0.920 *** Early in the course （〈24 hours） of AMI,sST2 usually increases *** increase of sST2 has an independent predictive value for the prognosis in AMI patients and provides complementary information to NT-proBNP or GRACE risk *** IL-33/sST2 ratio correlates with the 6-m

关键词： serum soluble ST2 interleukin-3 3 acute myocardial infarction risk stratification prognosis

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