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Efficacy of Chinese Medicine Acupoint Application Combined with Montelukast on Children with Perennial Allergic Rhinitis:A Randomized Controlled Trial

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Chinese Journal of Integrative Medicine 2020年第11期26卷 845-852页

作者： LI You-jin ZONG Ming DING Li-feng RUI Xiao-qing MA Bei-yin QIN Li-ping Department of Otorhinolaryngology-Head and Neck Surgery Shanghai Children's Medical CenterShanghai Jiaotong University School of MedicineShanghai(200127)China Department of Clinical Laboratory Shanghai East HospitalSchool of MedicineTong Ji UniversityShanghai(200120)China Department of Chinese Medicine Shanghai Children's Medical CenterShanghai Jiaotong University School of MedicineShanghai(200127)China Department of Medical Genetics and Molecular Diagnostic Laboratory Shanghai Children's Medical CenterShanghai Jiaotong University School of MedicineShanghai(200127)China Department of Chinese Medicine Xinhua HospitalShanghai』aotong University School of MedicineShanghai(200090)China

Objective To evaluate the efficacy of Chinese medicine acupoint application(CMAA)combined with Western medicine for perennial allergic rhinitis(PAR)in *** In this prospective,parallel,randomized,placebo-controlled and single-blind trial from August to September,2017,180 children with PAR were randomly assigned to an integrative group(CMAA and Montelukast),CMAA group(CMAA and placebo tablet),or Montelukast group(placebo CMAA and Montelukast).Participants were applied with CMAA for 6 sessions over 2 weeks,and/or Montelukast Chewable Tablet orally once daily for 12 *** changes in severity of symptoms were measured by Visual Analog Scale(VAS)and rhinitis control assessment test(RCAT)at 0,2,4 and 12 weeks of *** samples were collected for serum interleukin-4,interferon gammaγand T helper type 1(Th1)/Th2 flow cytometric analysis at the time points of 0,4 and 12 *** Eight cases dropped out from the trial,3 in the integrative group,2 in the CMAA group and 3 in the Montelukast *** VAS scores decreased significantly while the RCAT scores increased significantly in all three groups at 4 and 12 weeks compared with baseline(P4 weeks(P4 and 12 weeks,the scores of nasal congestion,sneezing,sleep problem,and rhinitis symptom control in the integrative and CMAA groups increased significantly compared with baseline(P434).

关键词： allergic rhinitis Chinese medicine acupoint application Montelukast interferon gamma/interleukin-4 T helper type 1/T helper type 2

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