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Pingyangmycin-regulated Expressions of adhesion molecules in Human Venous Malformation Endothelial Cells

Journal of Huazhong University of Science and Technology(Medical Sciences) 2012年第5期32卷 760-766页

作者：贾玉林贾俊赵怡芳 Department of Oral and Maxillofacial Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and Technology Department of Oral and Maxillofacial Surgery College & Hospital of StomatologyWuhan University

Pingyangmycin (bleomycin A5 hydrochloride,PYM) is one of the anti-neoplastic agents which have been commonly used to treat venous ***,the underlying mechanism by which PYM treats venous malformations remains poorly *** was reported that venous endothelial cells could recruit neutrophils via adhesion molecules (E-selectin,ICAM-1,ICAM-3,VCAM-1) during the acute/chronic inflammation and subsequent histological fibrosis after sclerotherapy with *** study explored if the expression of E-selectin,ICAM-1,ICAM-3 and VCAM-1 in human venous malformation endothelial cells could be affected by *** were cultured from human venous malformation *** of E-selectin,ICAM-1,ICAM-3 and VCAM-1 on HVMECs in response to PYM were analyzed by cell *** relative levels of mRNA expression in the cells were *** results showed that PYM up-regulated the expressions of E-selectin,ICAM-3,VCAM-1 and ICAM-1 in both time-and concentration-dependent *** findings suggested that PYM could induce the expression of adhesion molecules in HVMECs,which might be a possible mechanism by which sclerotherapy by intralesional injection of PYM treats venous malformations.

关键词： E-selectin intercellular adhesion molecule-1 intercellular adhesion molecule-3 vascular cell adhesion molecule-1 cell culture

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