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Inhibition of integrin-linked kinase by angiotensin II receptor antagonist, irbesartan attenuates podocyte injury in diabetic rats

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Chinese Medical Journal 2012年第5期125卷 888-893页

作者： DAI Hou-yong ZHENG Min TANG Ri-ning MA Kun-ling NI Jie LIU Bi-cheng Department of Nephrology Zhongda Hospital SoutheastUniversity School of Medicine Nanjing Jiangsu 210009 China Department of Nephrology Affiliated Hospital of NantongUniversity Nantong Jiangsu 226001 China

Background integrin-linked kinase （ILK） dysregulation is involved in the progression of diabetic nephropathy （DN）. The aim of this study was to investigate the effects of angiotensin II receptor blocker （ARB）, i... 详细信息

关键词： integrin-linked kinase diabetic nephropathy angiotension H receptor blocker podocyte injury

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Epithelial to mesenchymal transition in the progression of tubulointerstitial fibrosis

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Chinese Medical Journal 2007年第21期120卷 1925-1930页

作者： LI Min-xia LIU Bi-cheng Institute of Nephrology Zhong Da Hospital Southeast University Nanjing 210009 China

Objective To review the mechanisms of epithelial to mesenchymal transition （EMT） and its role in the progression of tubulointerstitial fibrosis. Data sources The data used in this review were obtained mainly from the studies of EMT reported from 2000-2006. Study selection Relevant articles on studies of EMT in tubulointerstitial fibrosis were selected. Data were mainly extracted from the 45 articles listed in the reference section of this review. Results The process of EMT has gained wide recognition as candidate mechanism in progression of chronic fibrotic disorders. New markers were identified and facilitate the observation of EMT. EMT is regulated by many factors through activation of kinase-dependent signaling cascades. Recent findings suggest that EMT is a reversible process, which can be controlled by factors for their epithelial inducing activities. Conclusion Remarkable progresses of EMT research have been made recently. Preventing or reversing EMT is a promising strategy against renal fibrosis.

关键词： epithelial to mesenchymal transition connective tissue growth factor transforming growth factor integrin-linked kinase tubulointerstitial fibrosis

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Influence of irbesartan on expression of ILK and its relationship with epithelial-mesenchymal transition in mice with unilateral ureteral obstruction

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Acta Pharmacologica Sinica 2007年第11期28卷 1810-1818页

作者： Bi-cheng LIU~1,Hui-ling XIA,Ji-ning WU,Xiao-liang ZHANG,Dian-ge LIU,Yu-xiang GONGInstitute of Nephrology,Zhong Da Hospital,Southeast University.Nanjing 210009,China Institute of Nephrology Zhong Da Hospital Southeast University Nanjing China

Aim:Irbesartan,a new antagonist of the type Ⅰ angiotensin Ⅱ receptor,has beenproven to be renal protective in both diabetic and non-diabetic nephropathy,butits exact mechanism is still *** we investigated the influence ofirbesartan on the expression of the integrin-linked kinase (ILK) and its relation-ship with epithelial-mesenchymal transition (EMT) in mice with unilateral ureteralobstruction (UUO).Methods:The mice were randomly divided into 3 groups:sham operation (C,n=20),UUO (n=40),and UUO with irbesartan treatment(UUO+irbesartan,n=40).Irbesartan was given at a dose of 50 mg/kg body weightper day by *** experimental animals in the control group received thesame volume of vehicle (0.9% saline solution).The animals were sacrificed at d 1,3,7,and 14,respectively,after the ***:The expression of the ILK atmRNA and protein levels were significantly increased in the UUO group 1 d afterthe surgery,which was significantly decreased by treatment with irbesartan (P<0.01,respectively).The expression of α-smooth muscle actin (α-SMA) was sig-nificantly increased,while E-cadherin was decreased in mice with UUO at d 3 afterthe *** with irbesartan significantly abrogated such effects (P<0.01).The immunohistochemistry analysis indicated that the protein expressionof the ILK was positively correlated with α-SMA,but negatively with ***:These results suggested that irbesartan attenuated renaltubulointerstitial fibrosis in UUO mice,which may be related to the inhibition ofILK expression,subsequently preventing the tubular EMT.

关键词： irbesartan integrin-linked kinase epithelialmesenchymal transition tubulointerstitial fibrosis

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Correlation of the nuclear accumulation of CTNNB1 and colonic tumorigenesis

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Chinese Medical Journal 2006年第13期119卷 1113-1117页

作者： QIU Zhe-fu Maruyama Keiji HAN De-min Nakamura Satoshi Second Department of Surgery Hamamatsu University School of Medicine 1-20-1 Handayama Hamamatsu 431-3192 Japan Beijing Otolaryngology-Head and Neck Surgery Research Centre Affiliated Beijing Tongren Hospital of Capital University of Medical Sciences Beijing 100005 China

CTNNB1 （or beta-catenin） is regarded as a central effecter in molecules of the wingless/Wnt signalling pathway, It is cadherin mediated cell to forms a complex with a key component of the cell adhesion system and the protein product of adenomatous polyposis coil （APC）, glycogen synthase kinase 3β （GSK3β） and conductin. One mutation of APC is also responsible for activation of wingless/Wnt signalling pathway and accumulation of free beta-catenin in the cell. Beta-catenin upregulates oncogenes, such as cyclin D1 and c-myc. Beta-catenin expression in cytoplasm and nuclei was reported to increase in many cases of intestinal tumorigenesis. In addition, the hyperexpression of integrin linked kinase （ILK） in colonic polyposis has been demonstrated.

关键词： beta catenin colonic polyps integrin-linked kinase piroxicam mice

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