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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2016年第6期17卷 484-492页

作者： Zhen-huan FANG Xia-ping FU Xue-ming HE College of Biosystems Engineering and Food Science Zhejiang University

For a quantitative understanding of light interaction with fruit tissue, it is critical to obtain two fundamental parameters： the absorption coefficient and the scattering coefficient of the tissue. This study was to investigate the optical properties of kiwifruit tissue at the wavelength of 632.8 nm. The total reflectance and total transmittance of kiwifruit tissue from three parts （including the flesh part, the seed part, and the seed-base part） were measured using a single integrating sphere system. Based on the measured spectral signals, the absorption coefficient pa and the reduced scattering coefficient Ps＇ of kiwifruit tissue were calculated using the inverse adding-doubling （lAD） method. Phantoms made from Intralipid 20% and India ink as well as a Biomimic solid phantom were used for system validation The mean values of μa and μs＇ of different parts of the kiwifruit were 0.031-0.308 mm-1 and 0.120-0.946 mm-1, respectively. The results showed significant differences among the Pa and Ps＇ of the three parts of the kiwifruit. The results of this study confirmed the importance of studying the optical properties for a quantitative understanding of light interaction with fruit tissue. Further investigation of fruit optical properties will be extended to a broader spectral region and different kinds of fruits.

关键词： Optical properties integrating sphere Inverse adding-doubling Kiwifruit

Determination of optical properties of normal and adenomatous human colon tissues in vitro using integrating sphere techniques

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World Journal of Gastroenterology 2005年第16期11卷 2413-2419页

作者： Hua-JiangWei DaXing Jian-JunLu Huai-MinGu Guo-YongWu YingJin InstituteofLaserLifeScience SouthChinaNormalUniversityGuangzhou510631GuangdongProvinceChina DepartmentofSurgery theFirstAffiliatedHospitalSunYat-SenMedicalUniversityGuangzhou510080GuangdongProvinceChina

AIM: The purpose of the present study is to compare the optical properties of normal human colon mucosa/submucosa and muscle layer/chorion, and adenomatous human colon mucosa/submucosa and muscle layer/chorion in vitro at 476.5, 488, 496.5, 514.5 and 532 nm. We believe these differences in optical properties should help differential diagnosis of human colon tissues by using optical ***: In vitro optical properties were investigated for four kinds of tissues: normal human colon mucosa/submucosa and muscle layer/chorion, and adenomatous human colon mucosa/submucosa and muscle layer/chorion. Tissue samples were taken from 13 human colons (13 adenomatous, 13 normal). From the normal human colons a total of 26 tissue samples, with a mean thickness of 0.40 mm, were used (13 from mucosa/submucosa and 13 from muscle layer/chorion), and from the adenomatous human bladders a total of 26 tissue samples, with a mean thickness of 0.40 mm, were used (13 from mucosa/submucosa and 13 from muscle layer/chorion). The measurements were performed using a double-integratingsphere setup and the optical properties were assessed from these measurements using the adding-doubling method that was considered ***: The results of measurement showed that there were significant differences in the absorption coefficients and scattering coefficients between normal and adenomatous human colon mucosa/submucosa at the same wavelength,and there were also significant differences in the two optical parameters between both colon muscle layer/chorion at the same wavelength. And there were large differences in the anisotropy factors between both colon mucosa/submucosa at the same wavelength, there were also large differences in the anisotropy factors between both colon muscle layer/chorion at the same *** were large differences in the value ranges of the absorption coefficients, scattering coefficients and anisotropy factors between both colon mucosa/submucosa,and there

关键词： Optical properties Laser Normal and adenomatous human colon tissues integrating sphere

A SIMPLE METHOD FOR PREDICTION OF THE REDUCED SCATTERING COEFFICIENT IN TISSUE-SIMULATING PHANTOMS

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Journal of Innovative Optical Health Sciences 2010年第1期3卷 53-59页

作者： JIANWEI FU GUOTAO QUAN HUI GONG Britton Chance Center for Biomedical Photonics Wuhan National Laboratory for Optoelectronics—Huazhong University of Science and Technology Wuhan 430074P.R.China

This paper proposes a method for predicting the reduced scattering coefficients of tissuesimulating phantoms or the desired amount of scatters for producing phantoms according to Mie scattering theory without measurements with other *** concentration of the scatters TiO2 particles is determined according to Mie theory calculation and added to transparent host epoxy resin to produce phantoms with different reduced scattering *** India Ink is added to alter the absorption coefficients of the *** reduced scattering coefficients of phantoms are measured with single integrating sphere *** results show that the measurements are in direct proportion to the concentration of TiO2 and have identical with Mie theory calculation at multiple *** method proposed can accurately determine the concentration of scatters in the phantoms to ensure the phantoms are qualified with desired reduced scattering coefficients at specified *** investigation should be possible to manufacture the phantom simply in reasonably accurate for evaluation of biomedical optical imaging systems.

关键词： Mie scattering theory integrating sphere optical imaging

Effect of purification,dehydration,and coagulation processes on the optical parameters of biological tissues

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Chinese Optics Letters 2021年第1期19卷 69-74页

作者： Halil Arslan Bahar Pehlivanoz Faculty of Technology Electrical and Electronics Engineering DepartmentSakarya University of Applied SciencesSakaryaTurkey

In this study,the effects of purification,dehydration,and coagulation processes on the absorption and reduced scattering coefficients of chicken liver tissues have been investigated by using a single integrating sphere *** purification process performed on the tissue samples to remove blood residue has been found to cause a slight change in the optical *** the dehydration process brings about an increase in the absorption coefficient due to the water loss,no direct relationship has been observed between the reduced scattering coefficient and the dehydration level of the *** addition,it has been observed that there was a relatively small increase in the absorption coefficient and a significant increase in the reduced scattering coefficient after the coagulation ***,it can be said that the optical penetration depth decreased significantly after dehydration and coagulation processes unlike blood ***,fluence rate distributions inside the fresh,blood purified,dehydrated,and coagulated tissue models have been investigated by using the Monte Carlo modeling of photon transport in multilayered tissues simulation code.

关键词： optical properties dehydration coagulation integrating sphere IAD

DEVELOPMENT AND PRELIMINARY APPLICATION OF OBJECTIFYING SYSTEM FOR TCM COLOR INSPECTION

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Transactions of Nanjing University of Aeronautics and Astronautics 2012年第4期29卷 395-403页

作者：郑冬梅戴振东王鸿谟南京航空航天大学机电学院中北大学软件学院首都医科大学中医药学院

An objectifying system for color inspections of traditional Chinese medicine （CITCM） is developed. The entire system includes two parts ： The hardware and the software. The hardware is an image acquiring device under a standard lighting condition, and it mainly includes a xenon lamp with color temperature of 5 500 K as light source, an integrating sphere used for diffusing light and a high resolution CCD camera. The software is used for digital image processing, and the procedure is divided into three steps. Firstly the skin/non-skin classifi- cation is performed by utilizing the threshold in chrominance channels of the RGB color space. Secondly, the fa- cial features are localized by using the image segmentation and coordinates sorting. Finally, the facial special re- gion（SR） corresponding to five internal organs is achieved by utilizing masks designed to take advantage of mor- phology. Subsequently, the chromaticity is calculated. The system is tested by taking 83 samples of 30 young and 53 elderly people. The experiment shows that there is significant difference of all SRs between the young and the elderly, and the system has better performance for objectifying research of CITCM.

关键词： color inspection special region integrating sphere image processing chromaticity significant dif- ference

Different Optical Properties between Human Hepatocellular Carcinoma Tissues and Non-tumorous Hepatic Tissues In Vitro

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2011年第4期31卷 515-519页

作者：于愿肖朝文陈堃郑建伟张俊赵新阳薛新波 Department of Biliary and Pancreatic Surgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and Technology

There has been an ongoing search for clinically acceptable methods for the accurate,efficient and simple diagnosis and prognosis of hepatocellular carcinoma（HCC）.Optical spectroscopy is a technique with potential clinical applications to diagnose cancer *** purpose of this study was to obtain the optical properties of HCC tissues and non-tumorous hepatic tissues and identify the difference between them.A total of 55 tissue samples（HCC tissue,n=38;non-tumorous hepatic tissue,n=17） were surgically resected from patients with *** optical parameters were measured in 10-nm steps using single-integrating-sphere system in the wavelength range of 400 to 1800 *** was found that the optical properties and their differences varied with the wavelength for the HCC tissue and the non-tumorous hepatic tissue in the entire wavelength range of *** absorption coefficient of the HCC tissue（1.48±0.99,1.46±0.88,0.86±0.61,2.15±0.53,0.54±0.10,0.79±0.15 mm-1） was significantly lower than that of the non-tumorous hepatic tissue（2.79±1.73,3.13±1.47,3.06±2.79,2.57±0.55,0.62±0.10,0.93±0.16 mm-1） at wavelengths of 400,410,450,1450,1660 and 1800 nm,respectively（P0.05）.The reduced scattering coefficient of HCC tissue（5.28±1.70,4.91±1.54,1.26±0.35 mm-1） and non-tumorous hepatic tissue（8.14±3.70,9.27±3.08,2.55±0.57 mm-1） was significantly different at 460,500 and 1800 nm respectively（P0.05）.These results show different pathologic liver tissues have different optical *** provides a better understanding of the relationship between optical parameters and physiological characteristics in human liver *** it would be very useful for developing a non-invasive,real-time,simple and efficient way for medical management of HCC in the future.

关键词： carcinoma hepatocellular optical properties integrating sphere

Recalibration of working standard lamps

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Journal of Measurement Science and Instrumentation 2016年第3期7卷 291-296页

作者： E M El-Moghazy F M EL-Sharkawy Alaa-Eldin Abd-Elmageed Photometry Department National Institute for Standard(NIS)

In the present work, recalibration of the National Institute for Standards （NIS, Egypt） working standard lamps from Osram Inc. and their associated expanded uncertainty budget were done. A set-up composed of an integrating sphere, a standard photometer and a group of five luminous flux standard lamps ranged from 25 to 200 W calibrated and traceable to the National Physical Laboratory （NPL, UK） is used to measure and recalibrate the total luminous flux for these five working standard lamps. After recalibration, NIS （Egypt） maintains the national scales for luminous flux in lumen.

关键词： luminous flux working standard lamps standard photomer integrating sphere