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Circulating insulin-like growth factor-binding protein 3 as prognostic biomarker in liver cirrhosis

World Journal of Hepatology 2016年第17期8卷 739-748页

作者： Carina Gabriela Correa Bruno da Silveira Colombo Marcelo Fernando Ronsoni Pedro Eduardo Soares e Silva Leonardo Fayad Telma Erotides Silva Letícia Muraro Wildner Maria Luiza Bazzo Esther Buzaglo Dantas-Correa Janaína Luz Narciso-Schiavon Leonardo de Lucca Schiavon Division of Gastroenterology Federal University of Santa Catarina Department of Clinical Analysis Federal University of Santa Catarina

AIM: To investigate the prognostic significance of insulin-like growth factor-binding protein 3(IGFBP-3) in patients with ***: Prospective study that included two cohorts: outpatients with stable cirrhosis(n = 138) and patients hospitalized for acute decompensation(n = 189). Development of complications, mortality or liver transplantation was assessed by periodical phone calls and during outpatient visits. The cohort of stable cirrhosis also underwent clinical and laboratory evaluation yearly(2013 and 2014) in predefined study visits. In patients with stable cirrhosis, IGFBP-3 levels were measured at baseline(2012) and at second re-evaluation(2014). In hospitalized subjects, IGFBP-3 levels were measured in serum samples collected in the first and in the third day after admission and stored at-80 ℃. IGFBP-3 levels were measured by ***: IGFBP-3 levels were lower in hospitalized patients as compared to outpatients(0.94 mcg/mL vs 1.69 mcg/m L, P < 0.001) and increased after liver transplantation(3.81 mcg/m L vs 1.33 mcg/mL, P = 0.008). During the follow-up of the stable cohort, 17 patients died and 11 received liver transplantation. Bivariate analysis showed that death or transplant was associated with lower IGFBP-3 levels(1.44 mcg/mL vs 1.74 mcg/m L, P = 0.027). The Kaplan-Meier transplant-free survival probability was 88.6% in patients with IGFBP-3 ≥ 1.67 mcg/mL and 72.1% for those with IGFBP3 < 1.67 mcg/mL(P = 0.015). In the hospitalized cohort, 30-d mortality was 24.3% and was independently associated with creatinine, INR, SpO_2/FiO_2 ratio and IGFBP-3 levels in the logistic regression. The 90-d transplant-free survival probability was 80.4% in patients with IGFBP-3 ≥ 0.86 mcg/mL and 56.1% for those with IGFBP3 < 0.86 mcg/mL(P < 0.001). CONCLUSION: Lower IGFBP-3 levels were associated with worse outcomes in patients with cirrhosis, and might represent a promising prognostic tool that can be incorporated in clinical practice.

关键词： Liver cirrhosis Acute decompensation insulin-like growth factor binding protein 3 Acute-onchronic liver failure Prognosis

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Mendelian randomization provides evidence for a causal effect of serum insulin-like growth factor family concentration on risk of atrial fibrillation

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World Journal of Clinical Cases 2023年第36期11卷 8475-8485页

作者： Sha Lin Jie Tang Xing Li Gang Wu Yi-Fei Lin Yi-Fei Li Department of Pediatrics and Ministry of Education Key Laboratory of Women and Children's Diseases and Birth Defects West China Second University HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Medical Device Regulatory Research and Evaluation Center West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina

BACKGROUND Atrial fibrillation(AF)is one of the most common persistent arrhythmias among adult cardiovascular *** is important to identify potential risk factors for *** of the insulin-like growth factor(IGF)family exert a variety of effects on various cell types in the context of the pathogenesis of cardiovascular diseases,and previous population-based studies indicate associations between IGF family members and ***,the causal effects of IGF family members in AF have not been *** genetic relationships between IGF family members and *** MR was performed based on genome-wide association study(GWAS)datasets,and concentration levels of 14 IGF family members were *** initial MR analysis was conducted to identify single nucleotide polymorphisms potentially associated with IGF serum concentrations.A GWAS meta-analysis including 60620 AF cases and 970216 control participants of European ancestry was then conducted to identify AF causal ***-sample MR packages were used to perform MR analysis in ***-Egger,weighted median(WM),and inverse va-riance weighted(IVW)methods were *** Core Tip:Due to the high prevalence of atrial fibrillation(AF),and adverse outcomes related to it,it is important to identify risk factors associated with development of the ***-like growth factor(IGF)family members exert a variety of effects on various cell types in the context of the pathogenesis of cardiovascular diseases,and previous population-based studies indicate associations between IGF family members and ***,the causal effects of IGF family members in AF have not been *** results of the current study provide novel insights on the pathogenesis of AF,and implic-ations of serum IGF family member concentrations when assessing the risk of *** study generated evidence on the potential roles of developmental pathological effects in the pathogenesis of *** observational and experimental studie

关键词： Atrial fibrillation Genome-wide association study insulin-like growth factor binding protein 3 insulin-like growth factor family Mendelian randomization

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Effects of parenteral nutrition with and without GH on the GH/IGF-1 axis after hepatectomy in hepatocellular carcinoma with liver cirrhosis

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Frontiers of Medicine 2007年第3期1卷 287-293页

作者： CAO Jie LUO Shimin LIANG Lijian LAI Jiaming CHEN Shanming Department of General Surgery Affiliated Guangzhou First Municipal People’s HospitalGuangzhou Medical CollegeGuangzhou 510180China Department of Hepatobiliary Surgery The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510180China Department of Scientific Research and Education Affiliated Guangzhou First Municipal People’s HospitalGuangzhou Medical CollegeGuangzhou 510180China

Postoperative hepatic insulin-like growth factor-1(IGF-1)production may be severely disturbed in patients with liver *** alterations in the GH/IGF-1 axis are thought to play an important role in the protein catabolism that complicates major surgical *** aim of this study was to explore the effects of parenteral nutrition(PN)with and without growth hormone(GH)on the GH/IGF-1 axis after hepatectomy for hepatocellular carcinoma(HCC)with cirrhosis and evaluate the potential roles of recombinant human GH(rhGH)***-four patients with HCC with cirrhosis who underwent hepatectomy were randomly divided into two groups:a PN group(n=12)and an rhGH+PN group(n=12).Liver function,serum GH,IGF-1 and IGFBP-3 were measured before the operation and at postoperative days(POD)1 and ***-like growth factor-1 and IGFBP-3 mRNA in the liver tissue was detected by *** liver Ki67 immunohistochemistry staining was *** the same time,12 patients with cholelithiasis or liver hemangioma who underwent operation served as normal control *** POD 6,serum prealbumin,GH,IGF-1,IGFBP-3,hepatic IGF-1 mRNA,IGFBP-3 mRNA and liver Ki67 LI were higher in the rhGH+PN group than in the PN *** was no significant difference in the 6-and 12-month tumor-free survival rate and the median tumor-free survival time between the PN group and the rhGH+PN group(P>0.05).These data indicate that rhGH+PN could ameliorate the changes in the GH/IGF-1 axis after hepatectomy for HCC in the setting of cirrhosis.

关键词： carcinoma,hepatocellular parenteral nutrition growth hormone insulin-like growth factor I insulin-like growth factor binding protein 3

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