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Increase of insulin sensitivity in diabetic rats received Die-Huang-Wan, a herbal mixture used in Chinese traditional medicine

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Acta Pharmacologica Sinica 2002年第12期23卷 128-134页

作者： HSU Jen-Hao,LIOU Shorong-Shii,CHENG Juei-Tang Graduate Institute of Natural Products Kaohsiung Medical University Kaohsiung City Graduate Institute of Natural Products Kaohsiung Medical University Kaohsiung City Department of Pharmacology College of Medicine National Cheng Kung University Tainan City Taiwan China Department of Pharmacology College of Medicine National Cheng Kung University Tainan City Taiwan 70101 China

AIM: Effects on insulin sensitivity of Die-Huang-Wan, the herbal mixture widely used to treat diabetic disorder in Chinese traditional medicine, were investigated in vivo. METHODS: The obese Zucker rats were employed as insulin-resistant animal model. Also, insulin-resistance was induced by the repeated intraperitoneal injections of long-acting human insulin at 0.5 U/kg three times daily into adult male Wistar rats. insulin resistance was identified using the loss of tolbutamide (10 mg/kg) or electroacupuncture (EA)-induced plasma glucose lowering action. The plasma glucose concentration was examined by glucose oxidase assay. RESULTS: The plasma glucose-lowering action induced by tolbutamide was significantly enhanced in obese Zucker rats receiving the repeated administration of Die-Huang-Wan at dosage of 26 mg/kg for 3 d. Furthermore, administration of Die-Huang-Wan delayed the formation of insulin resistance in rats that were induced by the daily repeated injection of human long-acting insulin at 0.5

关键词： insulin sensitivity Die-Huang-Wan obese Zucker rats insulin resistance

Inhibition of pyruvate dehydrogenase kinase improves carbohydrate utilization in Nile tilapia by regulating PDK2/4-PDHE1αaxis and insulin sensitivity

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Animal Nutrition 2022年第4期11卷 25-37页

作者： Yuan Luo Wenhao Zhou Ruixin Li Samwel MLimbu Fang Qiao Liqiao Chen Meiling Zhang Zhen-Yu Du LANEH School of Life SciencesEast China Normal UniversityShanghai 200241China University of Dar Es Salaam Department of Aquaculture TechnologyDar Es Salaam 60091Tanzania UDSM-ECNU Joint Research Center for Aquaculture and Fish Biology(JRCAFB) Dar Es Salaam 60091Tanzania ECNU-UDSM Joint Research Center for Aquaculture and Fish Biology(JRCAFB) Shanghai 200241China

Pyruvate dehydrogenase kinases(PDKs)-pyruvate dehydrogenase E1αsubunit(PDHE1α)axis plays an important role in regulating glucose metabolism in ***,the regulatory function of PDKsPDHE1α axis in the glucose metabolism of fish is not well *** study determined whether PDKs inhibition could enhance PDHE1αactivity,and improve glucose catabolism in *** tilapia fingerlings(1.90±0.11 g)were randomly divided into 4 treatments in triplicate(30 fish each)and fed control diet without dichloroacetate(DCA)(38% protein,7% lipid and 45% corn starch)and the control diet supplemented with DCA,which inhibits PDKs through binding the allosteric sites,at 3.75(DCA3.75),7.50(DCA7.50)and 11.25 g/kg(DCA11.25),for 6 *** results showed that DCA3.75,DCA7.50 and DCA11.25significantly increased weight gain,carcass ratio and protein efficiency ratio(Pinsulin signaling pathway and glycogen synthase kinase 3β(P<0.05).Taken together,the present study demonstrates that PDK2/4 inhibition by using DCA promotes glucose utilization in Nile tilapia by activating PDHE1αan

关键词： Dichloroacetate Glucose utilization insulin sensitivity Nile tilapia PDK2/4-PDHE1αaxis

Perspectives on diacylglycerol-induced improvement of insulin sensitivity in type 2 diabetes

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Food Science and Human Wellness 2022年第2期11卷 230-237页

作者： Daoming Li Yang Zhu Yonghua Wang Qiong Zou Jinzhu Duan Dongxiao Sun-Waterhouse Baoguo Sun Beijing Advanced Innovation Center for Food Nutrition and Human Health Beijing Technology and Business UniversityBeijing 100048China School of Food and Biological Engineering Shaanxi University of Science and TechnologyXi’an 710021China School of Food Science and Engineering Guangdong Research Center of Lipid Science and Applied Engineering TechnologySouth China University of TechnologyGuangzhou 510640China Bioprocess Engineering Wageningen University and Research6700 AA WageningenNetherlands Guangzhou Yong-h Special Nutrition Technology Co.Ltd Guangzhou 510000China Guangzhou Institute of Pediatrics Guangzhou Women and Children's Medical CenterGuangzhou 510623China

Diacylglycerol(DAG)-based edible oils have attracted increasing research interest owing to their healthpromoting *** animal and human studies showed that an increased 1,2-DAG content in the liver and skeletal muscle may cause insulin ***,earlier studies using animal models or humans reported that dietary DAGs with a 1,2-DAGs to 1,3-D AGs ratio of approximately 3:7 could improve insulin sensitivity in type 2 diabetic *** conflict raises the question of whether there is a link between the ingested DAGs and endogenous DAGs during their *** make a contribution to this field,this review provides an overview of the metabolic pathways of ingested DAGs and biological roles of DAGs(ingested and endogenous)in the change of insulin ***,strategies for further investigations on the metabolism of DAGs are proposed.

关键词： Diacylglycerols Functional oil insulin sensitivity Lipidomics

The role of visceral adipose tissue on improvement in insulin sensitivity following Roux-en-Y gastric bypass:a study in Chinese diabetic patients with mild and central obesity

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Gastroenterology Report 2018年第4期6卷 298-303,I0002页

作者： Lei Zhao Liyong Zhu Zhihong Su Weizheng Li Pengzhou Li Yong Liu Shengping Liu Shaihong Zhu Department of General Surgery Third Xiangya HospitalCentral South UniversityNo 138 Tongzipo RoadChangshaHunan 410013China Department of Gastrointestinal Surgery First Affiliated HospitalUniversity of South ChinaNo 69 Chuanshan RoadHengyangHunan 421001China

Background:Most Chinese patients with type 2 diabetes mellitus(T2DM)have mild obesity and central *** obesity is combined with insulin *** aim of this study was to assess the effect of abdominal adipose tissue on insulin-sensitivity improvement after Roux-en-Y gastric bypass(RYGB)in Chinese diabetic patients with mild and central ***:Seventeen T2DM patients with a mean body mass index of 30.3 kg/m^(2) were scheduled for laparoscopic RYGB.A hyperinsulinemic-euglycemic clamp and dual-energy X-ray absorptiometry were performed prior to surgery and 3 months after *** primary end points were the correlations between insulin sensitivity and abdominal adipose tissue,including visceral adipose tissue(VAT)and subcutaneous adipose tissue(SAT),before and 3 months after ***:Indices of peripheral insulin sensitivity,including glucose-disposal rate(M value)and glucose infusion rate,were significantly increased after ***-fat mass,VAT and SAT were significantly reduced after *** pre-operative M value was significantly correlated with VAT mass(r=–0.57,P=0.02),but not correlated with SAT mass.M value changes after RYGB were highly correlated with changes in VAT mass(r=–0.59,P=0.01),percentage of VAT mass(r=–0.66,Pinsulin sensitivity and decreased VAT following RYGB in Chinese patients with mild and central *** and SAT were significantly decreased with improved insulin sensitivity after *** mass may be considered as an indication for gastric bypass during patient selection.

关键词： insulin sensitivity visceral adipose tissue gastric bypass hyperinsulinemic-euglycemic clamp type 2 diabetes mellitus non-morbid obesity

insulin sensitivity,βcell function,and adverse pregnancy outcomes in women with gestational diabetes

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Chinese Medical Journal 2022年第21期135卷 2541-2546页

作者： Yun Shen Yanwei Zheng Yingying Su Susu Jiang Xiaojing Ma Jiangshan Hu Changbin Li Yajuan Huang Yincheng Teng Yuqian Bao Minfang Tao Jian Zhou Department of Endocrinology and Metabolism Shanghai Clinical Center for DiabetesShanghai Sixth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200233China Department of Gynecology and Obstetrics Shanghai Sixth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200233China Shanghai Diabetes Institute Shanghai Key Laboratory of Diabetes MellitusShanghai Sixth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200233China

Background: The potential impact of β cell function and insulin sensitivity on adverse pregnancy outcomes in women with gestational diabetes mellitus (GDM) remains uncertain. We aimed to investigate the association between β cell dysfunction, insulin resistance, and the composite adverse pregnancy ***: This observational study included 482 women diagnosed with GDM during pregnancy. Quantitative metrics on β cell function and insulin sensitivity during pregnancy were calculated using traditional equations. The association of β cell dysfunction and insulin resistance with the risk of the composite adverse pregnancy outcomes was investigated using multivariable-adjusted logistic regression ***: Multivariable-adjusted odds ratios (ORs) of adverse pregnancy outcomes across quartiles of homeostatic model assessment for insulin resistance (HOMA-IR) were 1.00, 0.95, 1.34, and 2.25, respectively (P for trend = 0.011). When HOMA-IR was considered as a continuous variable, the multivariable-adjusted OR of adverse pregnancy outcomes was 1.34 (95% confidence interval 1.16-1.56) for each 1-unit increase in HOMA-IR. Multivariable-adjusted ORs of adverse pregnancy outcomes across quartiles of homeostatic model assessment for β cell function (HOMA-β) were 1.00, 0.51, 0.60, and 0.53, respectively (P for trend = 0.068). When HOMA-β was considered as a continuous variable, the multivariable-adjusted OR of adverse pregnancy outcomes was 0.57 (95% CI 0.24-0.90) for each 1-unit increase in HOMA-β. However, other quantitative metrics were not associated with the composite adverse pregnancy ***: We demonstrated a significant association of β cell function and insulin sensitivity with the risk of adverse pregnancy outcomes. We have provided additional evidence on the early identification of adverse pregnancy outcomes besides the glycemic values.

关键词： βcell function insulin sensitivity Adverse pregnancy outcomes

Association of vitamin D and magnesium with insulin sensitivity and their influence on glycemic control

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World Journal of Diabetes 2023年第1期14卷 26-34页

作者： Wan Nor Fazila Hafizan Wan Nik Hani Ajrina Zulkeflee Siti Nadirah Ab Rahim Tuan Salwani Tuan Ismail Department of Chemical Pathology School of Medical SciencesUniversiti Sains MalaysiaKota Bharu 16150KelantanMalaysia Faculty of Medicine and Health Sciences Universiti Sains Islam MalaysiaBandar Baru NilaiNilai 71800Negeri SembilanMalaysia Pathology Unit Faculty of Medicine and Defence HealthNational Defence University of MalaysiaKem Perdana Sungai Besi 57000Kuala LumpurMalaysia

insulin resistance increases the risk of developing diabetes,and the degree of resistance influences the glycemic control of patients with *** researchers have focused on improving insulin sensitivity in order to prevent diabetes-related complications and other chronic *** studies have also linked vitamin D levels to insulin secretion and resistance,given that both vitamin D and its receptor complex play important roles in regulating pancreaticβ-*** has been suggested that vitamin D supplementation improves vitamin D levels,but further research is needed to confirm this as neither insulin function nor glycemic control improves when vitamin D levels *** is a cofactor for many *** the role of magnesium in the management of diabetes has long been evaluated,it has not yet been determined whether magnesium supplements improve insulin ***,several researchers have found that patients with good glycemic control have high magnesium *** is closely related to vitamin D and is necessary for the transport and activation of vitamin D in *** supplementation with vitamin D and magnesium improves glycemic control in patients with diabetes.

关键词： Vitamin D Magnesium Diabetes insulin sensitivity insulin resistance Glycemic control

Interactions between myoblasts and macrophages under high glucose milieus result in inflammatory response and impaired insulin sensitivity

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World Journal of Diabetes 2024年第7期15卷 1589-1602页

作者： Wei Luo Yue Zhou Li-Ying Wang Lei Ai Department of Sports and Health Sciences Nanjing Sport InstituteNanjing 210014Jiangsu ProvinceChina Department of Exercise Physiology Beijing Sport UniversityBeijing 100084China Department of Sports Physiology Research Jiangsu Research Institute of Sports ScienceNanjing 210033Jiangsu ProvinceChina

BACKGROUND Skeletal muscle handles about 80% of insulin-stimulated glucose uptake and become the major organ occurring insulin resistance(IR).Many studies have confirmed the interactions between macrophages and skeletal muscle regulated the inflammation and regeneration of skeletal ***,despite of the decades of research,whether macrophages infiltration and polarization in skeletal muscle under high glucose(HG)milieus results in the development of IR is yet to be elucidated.C2C12 myoblasts are well-established and excellent model to study myogenic regulation and its responses to *** exploration of macrophages'role in myoblasts IR and the dynamics of their infiltration and polarization is *** To evaluate interactions between myoblasts and macrophages under HG,and its effects on inflammation and IR in skeletal *** We detected the polarization status of macrophages infiltrated to skeletal muscles of IR mice by hematoxylin and eosin and immunohistochemical ***,we developed an in vitro co-culture system to study the interactions between myoblasts and macrophages under HG *** effects of myoblasts on macrophages were explored through morphological observation,CCK-8 assay,Flow Cytometry,and enzyme-linked immunosorbent *** mediation of macrophages to myogenesis and insulin sensitivity were detected by morphological observation,CCK-8 assay,Immunofluorescence,and 2-NBDG *** The F4/80 and co-localization of F4/80 and CD86 increased,and the myofiber size decreased in IR group(P0.8).In McM+HG group,F4/80+CD86+CD206-cells,monocyte chemoattractant protein 1,TNFα,IL-1βand IL-6 were increased,and F4/80+CD206+CD86-cells and IL-10 were decreased compared with Mc+HG group and McM group(P0.8).Compered to M group,myotube area,myotube n

关键词： Macrophages phenotype Myoblasts Cross-talk Glucose toxicity Chronic inflammation insulin sensitivity

Nano-chromium picolinate and heat stress enhance insulin sensitivity in cross-bred sheep

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Animal Nutrition 2023年第2期13卷 173-184页

作者： Alex T.Hung Brian J.Leury Matthew A.Sabin Fahri Fahri Kristy DiGiacomo Tu-Fa Lien Frank R.Dunshea Faculty of Veterinary and Agricultural Sciences The University of MelbourneParkvilleVIC 3010Australia Murdoch Children's Research Institute The University of MelbourneParkvilleVIC 3010Australia Department of Animal Science National Chiayi UniversityChiayiChina Faculty of Biological Sciences The University of LeedsLeeds LS29JTUnited Kingdom

This study evaluated the effects of heat stress(HS)and dietary nano chromium picolinate(nCrPic)on metabolic responses of sheep to an intravenous glucose tolerance test(IVGTT),an intravenous insulin tolerance test(ITT)and an intramuscular adrenocorticotropin hormone(ACTH)challenge in ***-six sheep housed in metabolic cages were randomly allocated within 3 dietary groups(0,400 and 800 mg/kg supplemental nCrPic)to either thermoneutral(22℃)or cyclic HS(22 to 40℃)conditions for 3 *** plasma glucose tended to be increased during HS(P=0.052)and decreased by dietary nCrPic(P=0.013)while plasma non-esterified fatty acid concentrations were decreased(P=0.010)by ***-etary nCrPic reduced the plasma glucose area under the curve(P=0.012)while there were no significant effects of HS on plasma glucose area under the curve in response to the *** plasma insulin response over the first 60 min after the IVGTT was decreased by HS(P=0.013)and dietary nCrPic(P=0.022)with the effects being *** response to the ITT plasma glucose reached a nadir sooner(P=0.005)in sheep exposed to HS,although there was no effect on the depth of the *** nCrPic decreased(P=0.007)the plasma glucose nadir after *** the duration of the ITT plasma insulin concentrations were lower in sheep exposed to HS(P=0.013)whereas there was no significant effect of supplemental *** was no effect of either HS or nCrPic on cortisol response to *** nCrPic supple-mentation decreased(P=0.013)mitogen-activated protein kinase-8(JNK)and increased(P=0.050)carnitine palmitoyltransferase 1B(CPT1B)mRNA expression in skeletal *** of this experiment demonstrated that animals under HS and supplemented with nCrPic had greater insulin sensitivity.

关键词： Chromium picolinate Sheep Heat stress insulin sensitivity

insulin sensitivity of Term Newborns Exposed in Utero to HIV and Antiretrovirals in Yaoundé

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Open Journal of Endocrine and Metabolic Diseases 2023年第9期13卷 161-172页

作者： Francine Mendane Ekobena Audrey Christance Donfack Hortence Fouedjio Suzanne Ngo Um Sap Martine Claude Etoa Etoga Mesmin Dehayem Anne Boli Ongmeb Gabriel Loni Ekali Jean Claude Mbanya Eugène Sobngwi Internal Medicine Unit Essos Hospital Center Yaoundé Cameroon Faculty of Medicine and Biomedical Sciences University of Yaoundé 1 Yaoundé Cameroon Obstetrics and Gynecology Unit Yaoundé Central Hospital Yaoundé Cameroon Mother and Child Center Chantal Biya Foundation Yaoundé Cameroon Endocrinology and Metabolic Diseases Unit Yaoundé Central Hospital Yaoundé Cameroon Faculty of Health Sciences of Bamenda Bamenda Cameroon Biotechnology Center University of Yaoundé 1 Yaoundé Cameroon

Introduction: Antiretrovirals (ARVs) and the human immunodeficiency virus (HIV) are implicated in the onset of insulin resistance. They cross the placental barrier thereby inducing early modifications of the fetal environment. The aim of our study was to assess insulin sensitivity in full-term newborns exposed in utero to HIV and ARVs in Yaoundé. Materials and Methods: We conducted an analytical cross-sectional study in 2 maternities in the city of Yaoundé from November 2021 to June 2022. We generated two groups of newborns (NBs): one group born to HIV positive mothers on ARVs and the other control group born to HIV negative mothers. Clinical data from mothers and NBs were collected. A homeostatic model assessment of insulin resistance (HOMA-IR) like index with C peptide served to assess insulin sensitivity. We used the Spearman correlation to measure the strength of association between insulin sensitivity and the different variables. A p-value Results: Of 70 neonates included, 35 were born to HIV positive mothers on ARVs and 35 to HIV negative mothers. The median age of HIV positive and negative mothers was 30 (27 - 32) and 34 (24 - 47) years, respectively (p = 0.791). The body mass index before pregnancy as well as the average newborn weights were comparable in both groups. The ARV protocol associating Tenofovir, Lamivudine, Efavirenz was used by 97.1% of HIV positive mothers. In the exposed NBs group, C peptide was significantly lower (p insulin. Close metabolic monitoring of these newborns would allow early diagnosis and management of any glucose regulation disorder.

关键词： insulin sensitivity Newborns Antiretrovirals HIV C Peptide HOMA-IR