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Effort and Contribution of T-DNA insertion Mutant Library for Rice Functional Genomics Research in China:Review and Perspective

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Journal of Integrative Plant Biology 2012年第12期54卷 953-966页

作者： Yuxiao Chang Tuan Long Changyin Wu National Key Laboratory of Crop Genetic Improvement and National Center of Plant Gene Research(Wuhan) Huazhong Agricultural University

With the completion of the rice （Oryza sativa L.） genome-sequencing project, the rice research community proposed to characterize the func- tion of every predicted gene in rice by 2020. One of the most effective and high-throughput strategies for studying gene function is to employ genetic mutations induced by insertion elements such as T-DNA or transposons. Since 1999, with support from the Ministry of Science and Technology of China for Rice Functional Genomics Programs, large-scale T-DNA insertion mutant populations have been generated in Huazhong Agricultural University, the Chinese Academy of Sciences and the Chinese Academy of Agricultural Sciences. Currently, a total of 372,346 mutant lines have been generated, and 58,226 T-DNA or Tos17 flanking sequence tags have been isolated. Using these mutant resources, more than 40 genes with potential applications in rice breeding have already been identified. These include genes involved in biotic or abiotic stress responses, nutrient metabolism, pollen development, and plant architecture. The functional analysis of these genes will not only deepen our understanding of the fundamental biological questions in rice, but will also offer valuable gene resources for developing Green Super Rice that is high-yielding with few inputs even under the poor growth conditions of many regions of Africa and Asia.

关键词： Flanking sequence tags functional genomics insertion site rice T-DNA insertion mutant library.

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Five-Year Surveillance of Central Line Associated Bloodstream Infection in an Intensive Care Unit Population—A Retrospective Analysis

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Advances in Infectious Diseases 2022年第2期12卷 281-297页

作者： Theresia Lutufyo Yuan Li Hui Han Weidong Qin Geofrey Mahiki Mranda Xiaomei Chen Shandong University Cheelo College of Medicine Jinan China Department of Critical Care Medicine Qilu Hospital of Shandong University Jinan China Department of Gastrointestinal Surgery The Second Hospital of Shandong University Jinan China

Background: Central venous catheters (CVCs) are essential to current intensive care unit (ICU) practices as a tool for treating critically ill patients. However, the use of CVCs is associated with substantial risk of infection. Central line associated bloodstream infection (CLABSI) is increasing in prevalence each year and is among the major causes of bloodstream infection in ICU patients. Therefore, investigating the epidemiology and risk factors of CLABSI in ICU patients is important. Objective: This study aimed to investigate the incidence rates, causative pathogens and risk factors of CLABSI in an ICU population. Methods: A retrospective observational study was performed in an ICU at Qilu Hospital of Shandong University in China from January 2016 to December 2020. Patients with at least one CVC were enrolled, and information relevant to CVC use was recorded. The prevalence was calculated, and related risk factors were analyzed. Results: A total of 1920 catheters were identified, 507 of which were eligible for analysis. For each of the years 2016-2020, the incidence rates of CLABSI were 1.91, 3.18, 1.69, 2.97 and 1.27 per 1000 catheter days, respectively. The yeast Candida albicans was the most prevalent pathogen (16 [(3.2%]), followed by Gram-positive methicillin-resistant Staphylococcus aureus (11 [2.2%]) and the Gram-negative multidrug-resistant pathogen Acinetobacter baumanii. Risk factors associated with CLABSI development were age, (p = 0.05), Charlson comorbidity index > 5 (p Conclusion: Candida albicans was the most common causative microorganism, which was followed by Gram positive methicillin resistant Staphylococcus, MDR K. pneumoniae and Acinetobacter baumanii.

关键词： Central Venous Catheter insertion site Bloodstream Infection ICU Catheter Days

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Five-year changes in epidemiology of central line associated bloodstream infection in an intensive care unit-a retrospective observational study

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实用休克杂志（中英文） 2022年第1期6卷 58-64页

作者： Theresia Lutufyo Li Yuan Han Hui Qin Weidong Geoffrey Mahiki Chen Xiaomei Department of Critical Care Medicine Qilu Hospital of Shandong University Cheeloo College of Medicine Shandong University Department of Gastrointestinal Surgery The Second Hospital of Shandong University

This study aimed to explore epidemiological information on central line-associated bloodstream infection(CLABSI).A retrospective observational study was performed in an ICU at Qilu Hospital of Shandong University in China from January 2015 to December *** with at least one central venous catheters(CVCs)were enrolled,and recorded relative information relevant to the CVC *** prevalence was calculated,and related factors were analyzed.A total of 507 catheters were eligible for *** the years 2016~2020,the incidence rates of CLABSI were as follows,1.91,3.18,1.69,2.97 and 1.27 per 1000 catheter days,*** the pathogen,yeast infections with Candida albicaans were the most prevalent[16(3.2%)],followed by gram-positive methicillin-resistant Staphylococcus aureus[11(2.2%)],and the gram-negative multidrug-resistant pathogens Acinetobacter *** factors associated with the development of CLABSI were age,(P=0.05),Charlson comorbidity index>5(P=0.00),and duration of the central venous CVC placement(P=0.01).Our study showed that there has been a slight decrease of CLABSI rates over the period of five *** study identifies some risk factors in our ICU that may be important in the prevention of CLABSI in ICU populations.

关键词： Central venous catheter insertion site Bloodstream infection ICU

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