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Induction of inosine.containing mRNA during the inflammatory stress in C57BL/6 mouse

Science Bulletin 2003年第2期48卷 156-160页

作者： LUO Xiaoxing1, YANG Jinghua2 & R. Rabinovici2 1. Department of Pharmacology, The Fourth Military Medical University, Xi抋n 710032, China 2. Section of Trauma and Critical Care, Surgery Department, Yale Uni-versity, School of Medicine, New Haven, CT 06521, USA Department of Pharmacology The Fourth Military Medical University Xi’an China Section of Trauma and Critical Care Surgery Department Yale University School of Medicine New Haven USA

A-to-I RNA editing is a recently discovered process of post-transcription modification of pre-mRNA by adenosine deamination that results in the production of pro-teins not inherent in the genome. The present study aimed to identify a role for A-to-I RNA editing in the acute inflamma-tion. It was found that A-to-I edtiting activities of RNA edi-tases, ADARs, were upregulated in lung, spleen, thymus and lymph node of mouse during endotoxin stimulation. Impor-tantly, the number of inosine.in poly(A) RNA isolated from mouse lung and spleen was significantly increased in corre-lating with the induction of ADARs?editing activity. The in vitro synthesized RNA which did not contain inosine.was edited by thymus extracts and the generation of inosine.was greatly increased after editing in LPS treated thymus extract. Take together, these data suggest that A-to-I RNA editing by ADARs may play an important role in pathogenesis of in-flammation. The existence of high level of I-mRNA also sug-gests that more protein isoforms might be generated from a single gene via adenosine deamination by ADARs during inflammatory stress.

关键词： RNA editing ADAR lipopolysaccharide adenosine inosine.

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