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Co-culture of astrocytes with neurons from injured brain A time-dependent dichotomy

Neural Regeneration Research 2011年第35期6卷 2768-2772页

作者： Xiaojing Xu Min Wang Jing Liu Jingya Lv Yanan Hu Huanxiang Zhang Department of Cell Biology Medical College of Soochow University Jiangsu Provincial Key Laboratory of Stem Cell Research Suzhou 215123 Jiangsu Province China

As supportive cells for neuronal growth and development, much effort has been devoted to the role of astrocytes in the normal state. However, the effect of the astrocytes after injury remains elusive. In the present study, neurons isolated from the subventricular zone of injured neonatal rat brains were co-cultured with astrocytes. After 6 days, these astrocytes showed a mature neuron-like appearance and the number of surviving neurons, primary dendrites and total branches was significantly higher than those at 3 days. The neurons began to shrink at 9 days after co-culture with shorter and thinner processes and the number of primary dendrites and total branches was significantly reduced. These experimental findings indicate that astrocytes in the injured brain promote the development of neurons in the early stages of co-culture while these cells reversely inhibit neuronal growth and development at the later states.

关键词： injured brain astrocytes neurons neural plasticity neurogenesis neural regeneration

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