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inhibitor of dna binding 2 accelerates nerve regeneration after sciatic nerve injury in mice

Neural Regeneration Research 2021年第12期16卷 2542-2548页

作者： Zhong-Hai Huang Ai-Ying Feng Jing Liu Libing Zhou Bing Zhou Panpan Yu Guangdong-Hong Kong-Macao Institute of Central Nervous System Regeneration Ministry of Education Joint International Research Laboratory of Central Nervous System RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina Interdisciplinary Innovation Institute of Medicine and Engineering Beijing Advanced Innovation Center for Big Data-Based Precision MedicineBeihang UniversityBeijingChina

inhibitor of dna binding 2(Id2)can promote axonal regeneration after injury of the central nervous system.However,whether Id2 can promote axonal regeneration and functional recovery after peripheral nerve injury is currently unknown.In this study,we established a mouse model of bilateral sciatic nerve crush injury.Two weeks before injury,AAV9-Id2-3×Flag-GFP was injected stereotaxically into the bilateral ventral horn of lumbar spinal cord.Our results showed that Id2 was successfully delivered into spinal cord motor neurons projecting to the sciatic nerve,and the number of regenerated motor axons in the sciatic nerve distal to the crush site was increased at 2 weeks after injury,arriving at the tibial nerve and reinnervating a few endplates in the gastrocnemius muscle.By 1 month after injury,extensive neuromuscular reinnervation occurred.In addition,the amplitude of compound muscle action potentials of the gastrocnemius muscle was markedly recovered,and their latency was shortened.These findings suggest that Id2 can accelerate axonal regeneration,promote neuromuscular reinnervation,and enhance functional improvement following sciatic nerve injury.Therefore,elevating the level of Id2 in adult neurons may present a promising strategy for peripheral nerve repair following injury.The study was approved by the Experimental Animal Ethics Committee of Jinan University(approval No.20160302003)on March 2,2016.

关键词： axonal regeneration functional recovery inhibitor of dna binding 2 motor neuron neuromuscular junctions peripheral nerve reinnervation sciatic nerve injury

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