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Buyang Huanwu Decoction fraction protects against cerebral ischemia/reperfusion injury by attenuating the inflammatory response and cellular apoptosis

引用

Neural Regeneration Research 2013年第3期8卷 197-207页

作者： Yulian Jin Liuyi Dong Changqing Wu Jiang Qin Sheng Li Chunyan Wang Xu Shao Dake Huang Department of Pharmacology Key Laboratory of Anti-inflammatory and ImmunopharmacologyMinistry of Education Key Laboratory of Chinese Medicine Research and Development State Administration of Traditional Chinese MedicineAnhui Medical University Anhui Provincial Children's Hospital Anhui Institute of Materia Medica Hefei Qi-xing Medicine and Technology Co. Ltd. Synthetic Laboratory of Basic Medicine College Anhui Medical University

Buyang Huanwu Decoction fraction extracted from Buyang Huanwu Decoction contains saponins of Astragalus, total paeony glycoside and safflower flavones. The aim of this study was to demonstrate the neuroprotective effect and mechanism of Buyang Huanwu Decoction fraction on ischemic injury both in vivo and in vitro. In vivo experiments showed that 50-200 mg/kg Buyang Huanwu Decoction fraction reduced infarct volume and pathological injury in ischemia/reperfusion rats, markedly inhibited expression of nuclear factor-KB and tumor necrosis factor-a and promoted nestin protein expression in brain tissue. Buyang Huanwu Decoction fraction （200 mg/kg） exhibited significant effects, which were similar to those of 100 mg/kg Ginkgo biloba extract. In vitro experimental results demonstrated that 10-100 mg/L Buyang Huanwu Decoction fraction significantly improved cell viability, decreased the release of lactate dehydrogenase and malondialdehyde levels, and inhibited the rate of apoptosis in HT22 cells following oxygen-glucose deprivation. Buyang Huanwu Decoction fraction （100 mg/L） exhibited significant effects, which were similar to those of 100 mg/L Ginkgo biloba extract. These findings suggest that Buyang Huanwu Decoction fraction may represent a novel, protective strategy against cerebral ischemia/reperfusion injury in rats and oxygen-glucose deprivation-induced damage in HT22 cells in vitro by attenuating the inflammatory response and cellular apoptosis.

关键词： neural regeneration traditional Chinese medicine Buyang Huanwu Decoction fraction ischemia/reperfusion injury brain injury hippocampus neurons apoptosis inflammatory reactionoxidation traditional Chinese herbal medicines neuroprotection grants-supported paper photographs-containing paper neuroregeneration

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