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The association between the two more common genetic causes of spermatogenic failure:a 7-year retrospective study

Asian Journal of Andrology 2020年第6期22卷 642-648页

作者： Hong-Ge Li Li-Hong Fan Bei Liu Ye-Qing Qian Min Chen Yi-Xi Sun Min-Yue Dong Women's Hospital School of MedicineZhejiang UniversityHangzhou 310006China

Chromosomal abnormalities and Y chromosome microdeletions are considered to be the two more common genetic causes of spermatogenic ***,the relati on ship between chromosomal aberrations and Y chromosome microdeletio ns is still un *** study was to investigate the incidenee and characteristics of chromosomal aberrations and Y chromosome microdeletions in infertile men,and to explore whether there was a correlation between the two genetic defects of spermatogenic failure.A 7-year retrospective study was conducted on 5465 infertile men with nonobstructive azoospermia or *** analysis of peripheral blood lymphocytes was performed by standard G-banding techniques.Y chromosome microdeletions were screened by multiplex PCR amplification with six specific sequence-tagged site(STS)*** the 5465 infertile men analyzed,371(6.8%)had Y chromosome microdeletions and the prevalence of microdeletions in azoospermia was 10.5%(259/2474)and in severe oligozoospermia was 6.3%(107/1705).A total of 4003(73.2%)infertile men underwent karyotyping;370(9.2%)had chromosomal abnormalities and 222(5.5%)had chromosomal *** analysis was performed on 272(73.3%)patients with Y chromosome microdeletions and 77(28.3%)had chromosomal aberrations,all of which involved sex chromosomes but not *** was a sign ifica nt d iff ere nee in the frequency of chromosomal abno rmalities betwee n men with and without Y chromosome microdeletions(P<0.05).

关键词： azoospermia factor chromosomal aberrations infertile men nonobstructive azoospermia and oligozoospermia spermatogenic failure Y chromosome microdeletions

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Metabolic syndrome and prostate abnormalities in male subjects of infertile couples

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Asian Journal of Andrology 2014年第2期16卷 295-304,I0011页

作者： Francesco Lotti Giovanni Corona Linda Vignozzi Matteo Rossi Elisa Maseroli Sarah Cipriani Mauro Gacci Gianni Forti Mario Maggi Sexual Medicine and Andrology Unit Department of Experimental and Clinical Biomedical Sciences University of Florence Florence Endocrinology Unit Maggiore-Bellaria Hospital Bologna Department of Urology Careggi Hospital University of Florence Florence Italy

No previous study has evaluated systematically the relationship between metabolic syndrome （MetS） and prostate-related symptoms and signs in young infertile men. We studied 171 （36.5 ±8.3-years-old） males of infertile couples. MetS was defined based on the National Cholesterol Education Program Third Adult Treatment Panel. All men underwent hormonal （including total testosterone （TT） and insulin）, seminal （including interleukin-8 （IL-8）, seminal plasma IL-8 （sIL-8））, scrotal and transrectal ultrasound evaluations. Because we have previously assessed correlations between MetS and scrotal parameters in a larger cohort of infertile men, here, we focused on transrectal features. Prostate-related symptoms were assessed using the National Institutes of Health Chronic Prostatitis Symptom Index （NIH-CPSI） and the International Prostate Symptom Score （IPSS）. Twenty-two subjects fulfilled MetS criteria. In an age-adjusted logistic ordinal model, insulin levels increased as a function of MetS components （Wald = 29.5, P〈 0.0001） and showed an inverse correlation with TT （adjusted r = -0.359, P 〈 0.0001）. No association between MetS and NIH-CPSI or IPSS scores was observed. In an age-, TT-, insulin-adjusted logistic ordinal model, an increase in number of MetS components correlated negatively with normal sperm morphology （Wald -- 5.59, P〈 0.02） and positively with slL-8 levels （Wald = 4.32, P〈 0.05）, which is a marker of prostate inflammation, with prostate total and transitional zone volume assessed using ultrasound （Wald = 17.6 and 12.5, both P〈 0.0001）, with arterial peak systolic velocity （Wald = 9.57, P= 0.002）, with texture nonhomogeneity （hazard ratio （HR） = 1.87 （1.05-3.33）, P 〈 0.05）, with calcification size （Wald = 3.11, P 〈 0.05）, but not with parameters of seminal vesicle size or function. In conclusion, in males of infertile couples, MetS is positively associated with prostate enlargement, biochemical （slL8） and ultrasound-derived signs of prostate inflammation but

关键词： infertile men interleukin-8 metabolic syndrome prostate-related symptoms and sisns semen analysis transrectal ultrasound

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The silent spermatozoon： are man-made endocrine disruptors killing male fertility？

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Asian Journal of Andrology 2013年第2期15卷 165-168,I0004页

作者： Bradley D Anawalt Department of Medicine University of Washington Seattle WA 98195 USA

In 1992, a Danish group led by Skakkebaek , reported in a meta-analysis that global mean sperm counts were fallingandthat testicular cancer, hypospadias and cryptorchidism were increasing. They hypothesized that environmental factors were the cause. Their rectaanalysis was criticized subsequently for many methodological flaws. However, their controversial metamlysls and hypothesis spurred pubfic and scientific interest in the study of male reproductive function and stimulated more rigorous scientific work in the area. Subsequent research has not convincingly supported their hypothesis, However, it is caudal to continue high quality studies of the effects of drugs and manmade pollutants on male eeproductlve function.

关键词： DETERIORATING SEmen QUALITY SPERM COUNTS REFERENCE VALUES infertile men NO EVIDENCE DANISH men HEALTHY PERIOD DECLINE OBESITY

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