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Regulation of innate immune responses by rabies virus

Animal Models and Experimental Medicine 2022年第5期5卷 418-429页

作者： Haili Zhang Jingbo Huang Yumeng Song Xingqi Liu Meichen Qian Pei Huang Yuanyuan Li Ling Zhao Hualei Wang State Key Laboratory for Zoonotic diseases Key Laboratory for Zoonosis Research of the Ministry of EducationInstitute of Zoonosisand College of Veterinary MedicineJilin UniversityChangchunChina State Key Laboratory of Agricultural Microbiology Huazhong Agricultural UniversityWuhanChina

Rabies virus(RABV)is an infectious and neurotropic pathogen that causes rabies and infects humans and almost all warm-blooded animals,posing a great threat to people and public *** is well known that innate immunity is the critical first line of host defense against viral *** monitors the invading pathogens by recognizing the pathogen-associated molecular patterns and danger-associated molecular patterns through pattern-recognition receptors,leading to the production of type I interferons(IFNα/β),inflammatory cytokines,and chemokines,or the activation of autophagy or apoptosis to inhibit virus *** the case of RABV,the innate immune response is usually triggered when the skin or muscle is bitten or ***,RABV has evolved many ways to escape or even hijack innate immune response to complete its own replication and eventually invades the central nervous system(CNS).Once RABV reaches the CNS,it cannot be wiped out by the immune system or any ***,a better understanding of the interplay between RABV and innate immu-nity is necessary to develop effective strategies to combat its ***,we review the innate immune responses induced by RABV and illustrate the antagonism mechanisms of RABV to provide new insights for the control of rabies.

关键词： apotosis autophagy infectious disease and host defense innate immunity and inflammation rabies virus

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