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Helicobacter pylori and oral pathology:Relationship with the gastric infection

World Journal of Gastroenterology 2014年第29期20卷 9922-9935页

作者： Isabel Adler Andrea Muio Silvia Aguas Laura Harada Mariana Diaz Adriana Lence Mario Labbrozzi Juan Manuel Muio Boris Elsner Alejandra Avagnina Valeria Denninghoff Oral Diseases Curriculum School of DentistryUniversity of Buenos AiresC1053ABJ Buenos AiresArgentina Department of Pathology Center for Medical Education and Clinical Research "Norberto Quirno" (CEMIC)1425 Buenos AiresArgentina National Scientific and Technical Research Council (CONICET) Career Member

Helicobacter pylori(***)has been found in the oral cavity and stomach,and its infection is one of the most frequent *** reviewed the literature and conducted a Topic Highlight,which identified studies reporting an association between ***-infection in the oral cavity and ***-positive stomach *** work was designed to determine whether *** is the etiologic agent in periodontal disease,recurrent aphthous stomatitis(RAS),squamous cell carcinoma,burning and *** selection focused on the highest quality studies and *** selected 48 articles reporting on the association between saliva and plaque and *** order to assess periodontal disease data,we included 12 clinical trials and 1 *** evaluated 13 published articles that addressed the potential association with RAS,and 6 with squamous cell *** publications focused on our questions on burning and *** is a close relation between *** infection in the oral cavity and the *** mouth is the first extra-gastric *** the role of *** in the etiology of squamous cell carcinoma,no evidence is still available.

关键词： Helicobacter pylori Oral pathology Gastric infecti

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Occult hepatitis B virus infection among Mexican human immunodeficiency virus-1-infected patients

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World Journal of Gastroenterology 2014年第37期20卷 13530-13537页

作者： Ma Teresa Alvarez-Muoz Angelica Maldonado-Rodriguez Othon Rojas-Montes Rocio Torres-Ibarra Fernanda Gutierrez-Escolano Guillermo Vazquez-Rosales Alejandro Gomez Onofre Muoz Javier Torres Rosalia Lira Unidad de Investigacion Medica en Enfermedades Infecciosas y Parasitarias Hospital de PediatriaCentro Medico Nacional Siglo XXIInstituto Mexicano del Seguro Social Clinica de Hepatitis Hospital de Infectologia Centro Médico Nacional La Raza Hospital General Regional No.72 IMSS Unidad de Investigacion Medica en Enfermedades Infecciosas y Parasitarias Hospital de PediatriaCentro Medico Nacional Siglo XXIInstituto Mexi-cano del Seguro Social Hospital Infantil de Mexico "Federico Gomez"

AIM: To determine the frequency of occult hepatitis B infection(OHBI) in a group of human immunodeficiency virus(HIV)-1+/ hepatitis B surface antigen negative(HBsAg)- patients from Mexico. METHODS: We investigated the presence of OHBI in 49 HIV-1+/HBsAg- patients. Hepatitis B virus(HBV) DNA was analyzed using nested PCR to amplify the Core(C) region and by real-time PCR to amplify a region of the S and X genes. The possible associations between the variables and OHBI were investigated using Pearson's χ2 and/or Fisher's exact ***: We found that the frequency of OHBI was 49% among the group of 49 HIV-1+/HBsAg- patients studied. The presence of OHBI was significantly associated with the HIV-1 RNA viral load [odds ratio(OR) = 8.75; P = 0.001; 95%CI: 2.26-33.79] and with HIVantiretroviral treatment with drugs that interfere with HBV replication(lamivudine, tenofovir or emtricitabine)(OR = 0.25; P = 0.05; 95%CI: 0.08-1.05). CONCLUSION: The OHBI frequency is high among 49 Mexican HIV-1+/HBsAg- patients and it was more frequent in patients with detectable HIV RNA, and less frequent in patients who are undergoing HIV-ARV treatment with drugs active against HBV.

关键词： Hepatitis B virus Occult hepatitis B virus infecti

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