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Decreased expression of β-nerve growth factor correlated with histological changes in a cryptorchidism rat model

Chinese Medical Journal 2012年第4期125卷 713-716页

作者： XIAN Hua XIAN Yun JIANG Chun-yi NIE Xiao WANG Xu-dong CHENG Hong-xia HE Jiang-hong WANG Yong-jun ZHOU Yan HUANG Jian-fei Surgical Comprehensive Laboratory Affiliated Hospital of Nantong University Nantong Jiangsu 226001 China Department of Pediatric Surgery Affiliated Hospital of Nantong University Nantong Jiangsu 226001 China Key Laboratory of Neuroregeneration Nantong UniversityNantong Jiangsu 226001 China Department of Pathology Affiliated Hospital of Nantong University Nantong Jiangsu 226001 China Surgical Comprehensive Laboratory Affiliated Hospital of Nantong University Nantong Jiangsu 226001 China Department of Pediatric Surgery Affiliated Hospital of Nantong University Nantong Jiangsu 226001 China Department of Pathology Affiliated Hospital of Nantong University Nantong Jiangsu 226001 China Surgical Comprehensive Laboratory Affiliated Hospital of Nantong University Nantong Jiangsu 226001 China

Background Nerve growth factor （NGF） is well-known for its important role in the development and maintenance of the nervous *** with its neurotrophic role,NGF has been detected in the testis of mouse,rat and human,suggesting an additional non-neurotrophic effect in the male reproductive *** expression of β-NGF in the undescended testes （cryptorchidism） has not been detected at *** aim of this study was to evaluate the expression of β-nerve growth factor mRNA and protein in experimental *** A unilateral mechanical cryptorchidism model in the Sprague-Dawley rat was established and the expression of β-NGF with histologic changes in experimental cryptorchidism were investigated using one step quantitative real-time reverse transcription-polymerase chain reaction,in situ hybridization histochemistry,immunofluorescence and hematoxylin-eosin *** The expression of β-NGF mRNA and protein were both significantly decreased in the development of unmarred testis and cryptorchidism-induced testis,and the decrease of β-NGF in cryptorchidism-induced testis was far greater than that in uninjured *** From this investigation,we confirmed a lower expression of β-NGF in undescended testes than in the development of testis.

关键词： nerve growth factor cryptorchidism rat infancy period sexual maturityperiod

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