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Particle focusing by 3D inertial microfluidics

Microsystems & Nanoengineering 2017年第1期3卷 204-211页

作者： Petra Paiè Francesca Bragheri Dino Di Carlo Roberto Osellame Istituto di Fotonica e Nanotecnologie(IFN)-CNR and Dipartimento di Fisica-Politecnico di Milano Piazza Leonardo da Vinci 3220133 MilanItaly Department of Bioengineering Department of Mechanical EngineeringCalifornia NanoSystems Instituteand Jonsson Comprehensive Cancer CenterUniversity of California-Los Angeles420 Westwood Plaza5121 Engineering VLos AngelesCA 90095USA

Three-dimensional(3D)particle focusing in microfluidics is a fundamental capability with a wide range of applications,such as on-chip flow cytometry,where high-throughput analysis at the single-cell level is ***,3D focusing is achieved mainly in devices with complex layouts,additional sheath fluids,and complex pumping *** this work,we present a compact microfluidic device capable of 3D particle focusing at high flow rates and with a small footprint,without the requirement of external fields or lateral sheath flows,but using only a single-inlet,single-outlet microfluidic sequence of straight channels and tightly curving vertical *** device exploits inertial fluidic effects that occur in a laminar regime at sufficiently high flow rates,manipulating the particle positions by the combination of inertial lift forces and Dean drag *** device is fabricated by femtosecond laser irradiation followed by chemical etching,which is a simple two-step process enabling the creation of 3D microfluidic networks in fused silica glass *** use of tightly curving three-dimensional microfluidic loops produces strong Dean drag forces along the whole loop but also induces an asymmetric Dean flow decay in the subsequent straight channel,thus producing rapid cross-sectional mixing flows that assist with 3D particle *** use of out-of-plane loops favors a compact parallelization of multiple focusing channels,allowing one to process large amounts of *** addition,the low fluidic resistance of the channel network is compatible with vacuum driven *** resulting device is quite interesting for high-throughput on-chip flow cytometry.

关键词： 3D fluidic network 3D particle focusing Dean flow inertial microfluidics

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