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Non-concomitant cortical structural and functional alterations in sensorimotor areas following incomplete spinal cord injury

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Neural Regeneration Research 2017年第12期12卷 2059-2066页

作者： Yu Pan Wei-bei Dou Yue-heng Wang Hui-wen Luo Yun-xiang Ge Shu-yu Yan Quan Xu Yuan-yuan Tu Yan-qing Xiao Qiong Wu Zhuo-zhao Zheng Hong-liang Zhao Department of Rehabilitation Beijing Tsinghua Changgung Hospital Beijing China School of Clinical Medicine Tsinghua University Beijing China Department of Electronic Engineering Tsinghua University Beijing China Department of Radiology Beijing Tsinghua Changgung Hospital Beijing China

Brain plasticity, including anatomical changes and functional reorganization, is the physiological basis of functional recovery after spinal cord injury（SCI）. The correlation between brain anatomical changes and functional reorganization after SCI is unclear. This study aimed to explore whether alterations of cortical structure and network function are concomitant in sensorimotor areas after incomplete SCI. Eighteen patients with incomplete SCI（mean age 40.94 ± 14.10 years old; male：female, 7：11） and 18 healthy subjects（37.33 ± 11.79 years old; male：female, 7：11） were studied by resting state functional magnetic resonance imaging. Gray matter volume（GMV） and functional connectivity were used to evaluate cortical structure and network function, respectively. There was no significant alteration of GMV in sensorimotor areas in patients with incomplete SCI compared with healthy subjects. Intra-hemispheric functional connectivity between left primary somatosensory cortex（BA1） and left primary motor cortex（BA4）, and left BA1 and left somatosensory association cortex（BA5） was decreased, as well as inter-hemispheric functional connectivity between left BA1 and right BA4, left BA1 and right BA5, and left BA4 and right BA5 in patients with SCI. Functional connectivity between both BA4 areas was also decreased. The decreased functional connectivity between the left BA1 and the right BA4 positively correlated with American spinal injury Association sensory score in SCI patients. The results indicate that alterations of cortical anatomical structure and network functional connectivity in sensorimotor areas were non-concomitant in patients with incomplete SCI, indicating the network functional changes in sensorimotor areas may not be dependent on anatomic structure. The strength of functional connectivity within sensorimotor areas could serve as a potential imaging biomarker for assessment and prediction of sensory function in patients with incomplete SCI. This trial was register

关键词： nerve regeneration incomplete spinal cord injury gray matter volume functional connectivity sensorimotor areas functionalmagnetic resonance imaging brain plasticity non-concomitant anatomical structure network imaging biomarker neural regeneration

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Treadmill step training promotes spinal cord neural plasticity after incomplete spinal cord injury

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Neural Regeneration Research 2013年第27期8卷 2540-2547页

作者： Tiansheng Sun Chaoqun Ye Jun Wu Zhicheng Zhang Yanhua Cai Feng Yue Department of Orthopedics Beijing Army General Hospital Department of Rehabilitation Beijing Physical Education Institute

A large body of evidence shows that spinal circuits are significantly affected by training, and that intrinsic circuits that drive locomotor tasks are located in lumbosacral spinal segments in rats with complete spinal cord transection. However, after incomplete lesions, the effect of treadmil training has been debated, which is likely because of the difficulty of separating spontaneous stepping from specific training-induced effects. In this study, rats with moderate spinal cord contusion were sub-jected to either step training on a treadmil or used in the model （control） group. The treadmil training began at day 7 post-injury and lasted 20 ± 10 minutes per day, 5 days per week for 10 weeks. The speed of the treadmil was set to 3 m/min and was increased on a daily basis according to the tolerance of each rat. After 3 weeks of step training, the step training group exhibited a sig-nificantly greater improvement in the Basso, Beattie and Bresnahan score than the model group. The expression of growth-associated protein-43 in the spinal cord lesion site and the number of tyrosine hydroxylase-positive ventral neurons in the second lumbar spinal segment were greater in the step training group than in the model group at 11 weeks post-injury, while the levels of brain-derived neurotrophic factor protein in the spinal cord lesion site showed no difference between the two groups. These results suggest that treadmil training significantly improves functional re-covery and neural plasticity after incomplete spinal cord injury.

关键词： neural regeneration spinal cord injury neurorehabilitation incomplete spinal cord injury treadmilltraining spinal cord plasticity growth-associated protein-43 tyrosine hydroxylase function recovery grants-supported paper neuroregeneration

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