检索结果-南通市图书馆

Mat hematical modeling and analysis of innate and humoral immune responses to dengue infections

International Journal of Biomathematics 2019年第7期12卷 95-110页

作者： Sulanie Perera S.S.N.Perera Research and Development Center for Mathematical Modeling Faculty of ScienceUniversity of ColomboColombo 3Sri Lanka

Dengue is an acute arthropode-borne virus,belonging to the family Flaviviridae.Currently,there are no vaccines or treatments available against dengue.Thus it is important to understand the dynamics of dengue in order to control the infection.In this paper,we study the long-term dynamics of the model that is presented in[S.D.Peera and S.S.N.Perera,Simulation model for dynamics of dengue with innate and humoral immune responses,Comput.Math.Methods Med.2018(2018)8798057,18 pp.doi:10.1155/2018/8798057]which describes the interaction of virus with infected and uninfected cells in the presence of innate and humoral immune responses.It was found the model has three equilibria,namely:infection free equilibrium,no immune equilibrium and endemic equilibrium,then analyzed its stability analytically.The analytical findings of each model have been exemplified by numerical simulations.Given the fact that intensity of dengue virus replication at early times of infection could determine clinical outcomes,it is important to understand the impact of innate immunity,which is believed to be the first line of defense against an invading pathogen.For this we carry out a simulation case study to investigate the importance of innate immune response on dengue virus dynamics.A comparison was done assurming that innate immunity was active;innate immunity was in quasi-steady state and innate immunity was inactive during the virus replication process.By a further analysis of the qualitative behavior of the quasi-steady state,it was observed that innate immune response plays a pivotal role in dengue virus dynamics.It can change the dynamical behavior of the system and is essential for the virus clearance.

关键词： Dengue humoral inate equilibrium stability quasi-steady state

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：