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Science China Chemistry 2025年第1期68卷 26-34页

作者： Yutao Zhang Juan Li Wei-Hong Zhu Zhiqian Guo Shanghai Key Laboratory of Functional Materials Chemistry Joint International Research Laboratory of Precision Chemistry and Molecular Engineering Institute of Fine Chemicals School of Chemistry and Molecular Engineering East China University of Science and Technology State Key Laboratory of Bioreactor Engineering Shanghai Frontier Science Research Base of Optogenetic Techniques for Cell MetabolismEast China University of Science & Technology

Sequence-activated chemiluminescence(CL) technique offers a unique approach to detecting specific biomolecules or cellular events with high sensitivity and spatial resolution. The fundamental principle behind sequence-activated CL probes involves tailoring highly-controllable CL signals in response to specific sequences or events of interest, thus enabling high-contrast signals under complex physiological conditions. This sequential activation could be triggered by enzymes, reactive oxygen species(ROS), biothiols or changes in the microenvironment. These unique sequence-activated CL probes bestow several advantages, including minimal background, deep-tissue penetration, and the ability of non-invasive or minimally invasive detection. The sequence-activated CL techniques represent a significant advancement in molecular imaging and diagnostics. In this mini-review, we focus on the latest developments in sequential CL probes, addressing the technical challenges and discussing the future trajectory by harnessing CL signaling and molecular recognition.

关键词： chemiluminescnece sequence-activation in-vivo bioimaging cyclic peroxide

Protective effects of Ecklonia cava extract on the toxicity and oxidative stress induced by hair dye in in-vitro and in-vivo models

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Journal of Oceanology and Limnology 2019年第3期37卷 909-917页

作者： OH Jae-Young RYU Bo-Mi YANG Hye-Won KIM Eun-A LEE Jung-Suck JEON You-Jin Department of Marine Life Science Jeju National UniversityJeju 63243Republic of Korea Jeju International Marine Science Center for Research & Education Korea Institute of Ocean Science and TechnologyJeju 63349Republic of Korea Research Center for Industrial Development of Seafood Gyeongsang National UniversityTongyeong 53064Republic of Korea

Oxidative hair dyes containingρ-phenylenediamine(PPD)are reported to induce an allergic reaction by promoting oxidative stress when absorbed through the *** the associated risk,these hair dyes remain popular owing to their convenience and sharpness of *** makes it important to minimize the cytotoxicity and oxidative stress induced by PPD-containing hair *** cava extract has been evaluated in different studies for its protective effects against external stress in fibroblasts and *** study was aimed at using in-vitro and in-vivo models to investigate the extract’s effects on cytotoxicity of and oxidative stress induced by PPD-containing hair *** of CIEL*a*b*Color space was first used to determine the range of *** extract that would not interfere with the coloring ability of the dye upon ***,the set ranges of *** extract(5% and 7%)were added to the hair dye and their toxicity assessed by evaluating the viability of fibroblasts and *** effects on developmental phenotypes and induction of oxidative stress by hair dye were evaluated and compared with those of hair dyes containing different contents of *** extract using an in-vivo zebrafish *** results showed that *** extract in hair dye could significantly decrease the cytotoxicity and levels of oxidative stress caused by hair dyes containing PPD in both in-vitro and in-vivo *** results suggest that the addition of 7% *** extract to 250μg/mL hair dye does not interfere with the coloring ability of the dye while showing significant protective eff ects against the hair *** study proposes that the use of *** extract as an adduct to hair dyes containing PPD reduces the cytotoxicity and oxidative stress induced by these hair dyes.

关键词： hair dye Ecklonia cava cytotoxicity oxidative stress in-vitro and in-vivo models

Position Verification of the RADPOS 4-D in-vivoDosimetry System

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International Journal of Medical Physics, Clinical Engineering and Radiation Oncology 2015年第4期4卷 318-325页

作者： Ryosuke Kohno Hidenori Yamaguchi Kana Motegi Fumiya Tanaka Tsunemichi Akita Yuki Nagata Kenji Hotta Tomoko Miyagishi Shie Nishioka Takeshi Dohmae Tetsuo Akimoto Particle Therapy Division National Cancer Center Hospital East Kashiwa Japan Graduate School of Pure and Applied Sciences University of Tsukuba Tsukuba Japan

The accuracy of the position measurements obtained by the radiation positioning system (RADPOS) was evaluated under static and dynamic conditions. In the static verifications, the RADPOS was fixed to the treatment couch in a photon treatment room and a proton treatment room, and was translocated with the treatment couch in x, y and z directions. Because the presence of magnetic and/or electrically conductive materials can cause a systematic shift in the measured position by distorting the RADPOS transmitted field, the effect of metals on the performance of the positioning system was also investigated. Dynamic verification was performed using the couch drive and a dynamic anthropomorphic thorax phantom. We thus confirmed the utility of RADPOS as a position sensor to perform in vivo dosimetry.

关键词： RADPOS MOSFET in-vivo Dosimetry Position Sensor Photon Therapy Proton Beam Therapy

in-vivoDosimetry Method for Measuring Peak Surface Dose Using Radiochromic Films during Computed Tomography Scanning of the Sinus

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International Journal of Medical Physics, Clinical Engineering and Radiation Oncology 2018年第2期7卷 151-159页

作者： Khaled Soliman Salman Altimyat Abdullah Alrushoud Ahmed Alenezi Mohammed Alkhorayef Medical Physics Department Prince Sultan Military Medical City Riyadh KSA Department of Radiological Sciences College of Applied Medical Sciences King Saud University Riyadh KSA

Purpose: During computed tomography (CT) helical scanning mode the patient surface dose distribution is assumed to be non-uniform, therefore point dose measurement methods may lead to imprecise estimation of the radiation dose received by the patient skin in particular. We have used XRQA2 films as in-vivo dosimeters to measure the entrance skin dose during sinus exams. Methods: The films were placed under the patient head rest in order to sample the entrance surface dose in-vivo. We have performed in-vivo film irradiation on 23 patients in this study to verify the clinical suitability of the method and were found adequate. Results: The measured average ESD in the sinus exam was 11.7 ± 1.0 mGy, the PSD was 15.7 ± 1.7 mGy and the CTDI(vol) was 13.3 ± 0.1 mGy. The ratio of ESD/CTDI(vol) and PSD/CTDI(vol) was 0.88 and 1.18 respectively. The results indicate that the scanner registered CTDI(vol) underestimates the PSD and in the same time it overestimates the ESD by 18% and 13.6% respectively. Conclusion: The observed differences between the ESD, PSD and CTDI(vol) although seem small for the radiation dose range measured during CT of the sinus [13.2 - 13.4] mGy, but important for the medical physicist to know, since monitoring of patients’ doses from CT examinations is becoming more mandatory. The use of radiochromic film as in-vivo dosimeter does not interfere with the clinical radiological exam and does not produce any image artifacts. The method can be used to study other CT examinations specially the ones with large beam width, high pitch factor and high dose exams. The method allows measurement of the peak skin dose, examination of the CT dose profile and the 2D dose distribution in the XZ plan.

关键词： Radiochromic Films Sinus CT in-vivo Dosimetry CTDI(Vol) Entrance Surface Dose

An in-vivoStudy during Combined Intracavitary and Interstitial Brachytherapy of Gynaecological Malignancies Using microMOSFET

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International Journal of Medical Physics, Clinical Engineering and Radiation Oncology 2017年第2期6卷 162-173页

作者： Ramapandian Seenisamy Vivekanandan Nagarajan Ashutosh Mukherji Parthasarathy Vedasoundaram K. S. Reddy Vivekanandam Singhavajala Vijayaprabhu Neelakandan Department of Radiotherapy RCC JIPMER Puducherry India Department of Medical Physics Cancer Institute Adyar Chennai India Department of Oncology MGMC & RI Puducherry India

Aim: To analyze the inter-fraction, intra-fraction uncertainties and to verify the delivered total dose with planned dose in the combined intracavitary-interstitial brachytherapy of gynaecological cancer patients using microMOSFET in-vivo dosimeter. Materials and Methods: Between May 2014 and March 2016, 22 patients who underwent brachytherapy treatments with an applicator combination of CT/MR compatible tandem, ring and Syed-Neblett template-guided rigid needles were included in this study. Specially designed microMOSFET, after calibration, was used to analyze the variations in dosimetry of combined intracavitary-interstitial application. Results: The standard deviation for Inter-fraction variation among 22 combined intracavitary interstitial applications ranged between 0.86% and 10.92%. When compared with the first fraction dose, the minimum and maximum dose variations were −9.5% and 26.36%, respectively. However, the mean doses varied between −5.95% and 14.49%. Intra-fraction variation, which is the difference of TPS calculated dose with first fraction microMOSFET-measured dose ranges from −6.77% to 8.68%. The variations in the delivered total mean dose in 66 sessions with planned doses were −3.09% to 10.83%. Conclusions: It is found that there was a gradual increase in microMOSFET measured doses as compared to the first fraction with that of subsequent fractions in 19 out of 22 applications. Tumor deformation and edema may be the influencing factors, but the applicator movements played a major role for the variations. We find that the microMOSFET is an easy and reliable system for independent verification of uncertainties during ICBT-ISBT treatments.

关键词： microMOSFET Intra-Fraction Variations in Brachytherapy Inter-Fraction Variations in Brachytherapy Combined Intracavitary and Interstitial Brachytherapy in-vivo Dosimetry in Brachytherapy Applicator Displacement Brachytherapy Uncertainties

Inter-Fraction and Intra-Fraction Variation in the Absorbed-Dose Delivery during Interstitial High Dose Rate Brachytherapy—A Study Using MicroMOSFET in-vivoDosimeter

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International Journal of Medical Physics, Clinical Engineering and Radiation Oncology 2017年第4期6卷 445-456页

作者： Seenisamy Ramapandian Vivekanandan Nagarajan Ashutosh Mukherji Parthasarathy Vedasoundaram K. S. Reddy Vivekanandam Singhavajala Vijayaprabhu Neelakandan Department of Radiotherapy RCC JIPMER Pondicherry India Department of Medical Physics Cancer Institute Chennai India Department of Oncology MGMC & RI Puducherry India

Background: The delivered dose has to be checked and verified with planned dose since precise and accurate dose delivery is essential in Brachytherapy. Sources of uncertainty during Brachytherapy are intra-fraction, inter-fraction and inter-application variations. in-vivo dosimetry is the direct method to monitor the radiation dose delivered to a patient during radiotherapy. In this study, assessment of the inter-fraction and intra-fraction variations in the interstitial Brachytherapy was done with microMOSFET. Aim: To analyze the inter-fraction variations in dose delivery during interstitial HDR Brachytherapy and to compare the measured point dose with the TPS-calculated point dose, intra-fraction variation, using the microMOSFET in-vivo dosimeter. Materials and Methods: From May 2014 to February 2016, 22 patients with Head and Neck cancers and 8 patients with Soft-Tissue Sarcomas (STS) were selected for this study. All these patients underwent CT imaging more than 24 hours after the application. Brachyvision 3DTPS and GammaMed Plus iX HDR unit were used for treatments. MicroMOSFET in-vivo dosimeter after calibration was used for the measurements of dose inside the treated volume. Intra & Inter-fraction variations were analyzed and reported. Results: The SD of inter-fraction variation among 22 Head & Neck patients ranges from 2.14% to 14.26%. Minimum & maximum dose variation with first fraction dose of patients ranged from -22.33% to +26.71% and the mean doses were -6.42% to +19.76%. Differences of TPS dose and microMOSFET measured first fraction dose, intra-fraction variation, ranged from -12.36% to +5.05%. The SD of inter-fraction variation for 8 STS patients was from 2.81% to 14.43%. Minimum and maximum doses vary from -38.72% to +25.74% and mean dose varies from -21.5% to +12.53%. Differences of point doses of TPS and measured, intra-fraction variation, were from -5.86% to 4.88%. Conclusions: MicroMOSFET has the potential to minimize the gross errors during mul

关键词： MicroMOSFET Interstitial Brachytherapy MicroMOSFET in Brachytherapy in-vivo Dosimetry in Brachytherapy Dose Verification in Brachytherapy

Production of porous Ni-Ti alloy and test of its biocompatibility under in-vivo conditions

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Journal of Biomedical Science and Engineering 2010年第12期3卷 1161-1168页

作者： Ali Kaya Gur Nuri Orhan Emine Unsaldi Ali Said Durmus Neriman Colakoglu Department of Metallurgy Education Technical Education FacultyFirat UniversityElazigTurkey Department of Surgery Faculty of VeterinaryFirat UniversityElazigTurkey Histology and Embryology Department Medical FacultyFirat UniversityElazigTurkey

Biomaterials have been out of commonly used materials in biomedical applications in recent years. Today among the mostly-used biocompatible metals are especially Ni-Ti alloys. For conducting this study, having extensive usage area in biomedical applications, Ni and Ti materials were utilized for an alloy production. Following being mixed using a suitable mixer at 49Ni/51Ti %wt., the alloy was exposed to cold pressure of 200 MPa and sintered in a mold. In addition, the material gained porosity appearance thanks to usage of the synthesized (SHS) method and then the final shape of the specimen was taken using the method of wire electro erosion discharge machining (WEDM). Afterwards, the specimen was subjected to the biocompatibility test in in-vivo environment by means of on a 3-year-old female dog.

关键词： Biomaterials NiTi Igntion Implant in-vivo

Biomimetic Hydroxyapatite Coated Titanium Screws Demonstrate Rapid Implant Stabilization and Safe Removal in-vivo

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Journal of Biomaterials and Nanobiotechnology 2015年第1期6卷 20-35页

作者： Jan Henrik Sorensen Lutz Durselen Ken Welch Torben Christian Sorensen Philip Procter Hakan Engqvist Maria Stromme Anita Ignatius Hartwig Steckel Department of Pharmaceutics and Biopharmaceutics Christian-Albrechts UniversityKielGermany Institute of Orthopaedic Research and Biomechanics Centre of Musculoskeletal ResearchUlmGermany Division for Nanotechnology and Functional Materials The Angstrom LaboratoryUppsala UniversityUppsalaSweden Stryker Trauma GmbH SchonkirchenGermany Stryker Trauma AG SelzachSwitzerland Division for Applied Materials Sciences The Angstrom LaboratoryUppsala UniversityUppsalaSweden

The early fixation of bone screws after surgical implantation still remains a challenge in the field of traumatology. Whilst hydroxyapatite (HA) coatings are known to enhance the fixation of implants;their removal at a later time-point may be problematic. An HA coating has been developed to demonstrate that both implant fixation and safe removal are feasible in the same design. Accordingly the aim of this study was to compare the in-vivo performance of thin biomimetic HA coated titanium screws to uncoated counterparts used as control after bilateral implantation in the femoral condyle of 36 New Zealand White Rabbits. The screws were analysed macroscopically, by histology, micro-CT and biomechanically at both two and six weeks post-implantation. The HA coated screws demonstrated excellent biocompatibility. At two weeks the HA coated screws demonstrated a significant increase in removal torque values as well as a strong trend towards higher pull-out forces. In addition histology confirmed a higher degree of osseointegration and direct bone to implant contact. At six weeks no difference in pull-out force and removal torque could be detected. SEM images confirmed the absence of any residual HA coating indicating a fast coating degradation in-vivo. The low level of removal torque after full osseointegration at 6 weeks supports the feasibility of safe and easy removal of the implant. The HA coating under study appears to offer a unique characteristic of enhanced fixation with a minimal increase in removal torque after full osseointegration. This may be of value in clinical applications where it is necessary to assure both screw fixation and later removal.

关键词： Biomimetic Hydroxyapatite in-vivo Screw Implant Removal Pull-Out Force Removal Torque

Mathematical Modelling of in-vivo Dynamics of HIV Subject to the Influence of the CD8+ T-Cells

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Applied Mathematics 2017年第8期8卷 1153-1179页

作者： Purity M. Ngina Rachel Waema Mbogo Livingstone S. Luboobi Strathmore Institute of Mathematical Sciences Strathmore University Nairobi Kenya

There have been many mathematical models aimed at analysing the in-vivo dynamics of HIV. However, in most cases the attention has been on the interaction between the HIV virions and the CD4+ T-cells. This paper brings in the intervention of the CD8+ T-cells in seeking, destroying, and killing the infected CD4+ T-cells during early stages of infection. The paper presents and analyses a five-component in-vivo model and applies the results in investigating the in-vivo dynamics of HIV in presence of the CD8+ T-cells. We prove the positivity and the boundedness of the model solutions. In addition, we show that the solutions are biologically meaningful. Both the endemic and virions- free equilibria are determined and their stability investigated. In addition, the basic reproductive number is derived by the next generation matrix method. We prove that the virions-free equilibrium state is locally asymptotically stable if and only if R0 < 1 and unstable otherwise. The results show that at acute infection the CD8+ T-cells play a paramount role in reducing HIV viral replication. We also observe that the model exhibits backward and trans-critical bifurcation for some set of parameters for R0 . This is a clear indication that having R0 is not sufficient condition for virions depletion.

关键词： HIV Endemic Equilibrium Global Stability in-vivo Disease-Free Equilibrium Basic Reproductive Number Backward Bifurcation

A Consensus Modeling Approach for the Determination of Stratum Corneum Thickness Using in-vivo Confocal Raman Spectroscopy

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Journal of Cosmetics, Dermatological Sciences and Applications 2012年第4期2卷 241-251页

作者： Thomas M. Hancewicz Chunhong Xiao Jesse Weissman Vickie Foy Shuliang Zhang Manoj Misra Advanced Measurement and Data Modeling Unilever Research & Development Trumbull USA Clinical Science Unilever Research & Development Trumbull USA Clinical Science Unilever Research & Development Trumbull USA.

The measurement of stratum corneum (SC) thickness from in-vivo Raman water concentration depth profiles is gaining in popularity and appeal due to the availability and ease of use of in-vivo confocal Raman measurement systems. The foundation of these measurements relies on high-quality confocal Raman spectroscopy of skin and the robust numerical analysis of water profiles, which allow for accurate determination of SC thickness. These measurements are useful for studying intrinsic skin hydration profiles at different body sites and for determining hydration properties of skin related to topically applied materials. While the use of high-quality in-vivo Raman instrumentation has become routine and its use for SC thickness measurement widely reported, there is lack of agreement as to the best method of computing SC thickness values from Raman water profiles. Several methods have been proposed and are currently in use for such computations, but none of these methods has been critically evaluated. The work reported in this paper describes a new method for the determination of stratum corneum thickness from in-vivo confocal Raman water profiles. The method represents a consensus approach to the problem, which was found necessary to apply in order to properly model and quantify the large diversity of water profile types encountered in typical in-vivo Raman water measurement. The methodology is evaluated for performance using three criteria: 1) frequency of minimum fitting error on modeling to a standard numerical function;2) frequency of minimum model error for consensus vs. individual SC thickness values;and 3) correlation with reflectance confocal microscopy (RCM) values for SC thickness. The correlation study shows this approach to be a reasonable replacement for the more tedious and time-consuming RCM method with R2 = 0.68 and RMS error = 3.7 microns over the three body sites tested (cheek, forearm and leg).

关键词： in-vivo Raman Spectroscopy Confocal Raman Spectroscopy Reflectance Confocal Microscopy Stratum Corneum Thickness