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Ultra-stable near-infrared Tm^(3+)-doped upconversion nanoparticles for in vivo wide-field two-photon angiography with a low excitation intensity

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Journal of Innovative Optical Health Sciences 2019年第3期12卷 67-77页

作者： Wen Liu Runze Chen Sailing He State Key Laboratory of Modern Optical Instrumentations Centre for Optical and Electromagnetic Research Zhejiang University Hangzhou 310058P.R.China School of Electrical Engineering Royal Institute of Technology Stockholm SE-10044 Sweden

Two-photon luminescence with near-infrared(NIR)excitation of upconversion nanoparticles(NPs)is of great importance in biological imaging due to deep penetration in high-scattering tissues,low auto-luminescence and good sectioning ***,common two-photon luminescence is in visible band with an extremely high exciation power density,which limits its ***,we synthesized NaYF_(4):Yb/Tm@NaYF_(4)upconversion NPs with strong twophoton NIR emission and a low excitation power ***,NaYF_(4):Yb/Tm@NaYF_(4)@SiO_(2)@OTMS@F127 NPs with high chemical stability were obtained by a modified multilayer coating method which was applied to upconversion NPs for thefirst *** addition,it is shown that the as-prepared hydrophillic upconversion NPs have great biocompatibility and kept stable for 6 hours during in vivo whole-body *** vessels with two-photon luminescence were clear even under an excitation power density as low as 25mW/cm^(2).Vivid visualizations of capillaries and vessels in a mouse brain were also obtained with low background and high *** of cheaper instruments and safer power density,the NIR two-photon luminescence of NaYF_(4):Yb/Tm@NaYF_(4)upconversion NPs could promote wider application of two-photon *** modified multilayer coating method could be widely used for upconversion NPs to increase the stable time of the in vivo *** work possesses a great potential for deep imaging and imaging-guided treatment in the future.

关键词： Ultra-stable upconversion nanoparticles two-photon luminescence in vivo brain angiography low excitation power density

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