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The interaction effect between advanced paternal age and paternal obesity is associated with the low implantation rate in couples with unexplained recurrent pregnancy loss

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Gynecology and Obstetrics Clinical Medicine 2021年第4期1卷 197-204页

作者： Shuo Li Yaqian Shen Yueting Zhu Hongchang Li Wenjie Jiang Junhao Yan Zi-Jiang Chen Center for Reproductive Medicine Cheeloo College of MedicineShandong UniversityJinanShandong250012China Key Laboratory of Reproductive Endocrinology of Ministry of Education Shandong UniversityJinanShandong250012China Shandong Key Laboratory of Reproductive Medicine JinanShandong250012China Shandong Provincial Clinical Research Center for Reproductive Health JinanShandong250012China National Research Center for Assisted Reproductive Technology and Reproductive Genetics Shandong UniversityJinanShandong250012China Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics Shanghai200135China Center for Reproductive Medicine Ren Ji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai200135China

Objective:To explore the roles of advanced paternal age(APA)and abnormal paternal weight on embryo quality and pregnancy outcomes for unexplained recurrent pregnancy loss(uRPL)couples who underwent preimplantation genetic testing for aneuploidies(PGT-A).Methods:This study included 779 uRPL couples who underwent their first PGT-A cycles between 2014 and *** patients’aging and nutritional status were quantified by paternal age and body mass index(BMI).Routine semen parameters and sperm DNA fragmentation index(DFI)were used to reflect the seminal *** formation rate and aneuploidy rate were used to reflect the embryo *** cancellation rate,implantation rate,pregnancy loss rate,and live birth rate were measured to evaluate the treatment efficiency from *** remove the interference of maternal age,only the women younger than 38 years old were *** univariate screening,interaction tests were performed in a generalized linear model(GLM)to further examine the effects of paternal age and BMI on each outcome ***:In the total population(779 cycles),there were no statistical differences in aneuploidy rate,cycle cancellation rate,implantation rate,pregnancy loss rate,and live birth rate,whether stratified by paternal age or paternal *** results occurred in the younger men(implantation rate,and live birth *** interaction testing,the results of GLM suggested that the interaction effect between APA and paternal obesity was associated with the low implantation rate of uRPL ***:For the uRPL couples seeking for PGT-A treatment,if the male patients have both advanced age and obesity,their spouses are at higher risks for embryo implantation failure

关键词： Advanced paternal age implantation rate Live birth rate Obesity Preimplantation genetic test Unexplained recurrent pregnancy loss

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A comparison of implantation, miscarriage and pregnancy rates of single and double day 3 embryo transfer between fresh and frozen thawed transfer cycles： a retrospective study

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Chinese Medical Journal 2014年第5期127卷 911-915页

作者： Liu Liu Tong Xiaomei Jiang Lingying Tinchiu Li Zhou Feng Zhang Songying Center of Reproductive Medicine Sir Run Run Shaw HospitalSchool of Medicine Zhejiang University Hangzhou Zhejiang 310006 China Department of Reproductive Medicine Jessop Wing Royal Hallamshire Hospital University of Sheffield UK

Background Reduced endometrial receptivity in hyperstimulated cycles may lead to a lower implantation rate and a lower clinical pregnancy rate,but it is unclear if it is also associated with an increase in pregnancy loss *** aim of this study was to compare the implantation,miscarriage,and pregnancy rates between fresh and frozen thawed transfer of one or two day-3 embryos,with a view to understanding whether or not reduced endometrial receptivity encountered in hyperstimulated cycles is associated with an increase in miscarriage *** This study involved a consecutive series of 1 551 single day-3 embryo transfer cycles and consecutive 5 919 double day-3 embryo transfer cycles in the Assisted Reproductive Unit of the Sir Run Run Shaw Hospital,Hangzhou,China,between January 2010 and December *** The implantation and clinical pregnancy rates （single embryo 30.7％ and double embryos 33.4％ and 51.4％）using fresh cycle were both significantly lower than that of frozen-thawed cycles （single embryo 35.8％ and double embryos 38.1％ and 57.8％）.There was no difference in biochemical loss or clinical miscarriage rates between the two *** Impairment of endometrial receptivity associated with ovarian hyperstimulation leads to implantation failure at a very early stage,resulting in an increased number of *** does not lead to increase in biochemical or clinical *** significantly reduced ongoing pregnancy rates in both fresh single and double embryo transfer are therefore due to failure to achieve a pregnancy,rather than pregnancy loss after conception.

关键词： pregnancy loss miscarriage in vitro fertilization embryo transfer implantation rate

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Clinical Outcomes of Transfer Vitrified-Thawed Day 4,8-Cell Embryos into Endometrium Prepared for Day 3 Embryos

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Reproductive and Developmental Medicine 2018年第2期2卷 95-99页

作者： Ji-Qiang Si Hannah Ya-Ning Chang Yan-Ping Kuang Qi-Feng Lyu Department of Assisted Reproduction Shanghai Ninth People’s HospitalShanghai Jiaotong University School of MedicineShanghai 200001People’s Republic of China

Objective:To determine the clinical outcomes of transfer of day 3,8-cell embryos into endometrium prepared for day 3 ***:This study performed a retrospective analysis of 1,190 retarded *** embryos underwent extended culture in vitro to select and vitrify day 4,8-cell embryos,followed by 176 frozen embryo transfer cycles(study group),matching 660 transfer cycles with single frozen day 3,8-cell embryos as the control(control group).Results:The study group achieved successful implantation rates,clinical pregnancy rate,and live-birth rates(20.45%,15.91%,14.20%,respectively),although these were lower than that in the control group(30.45%,27.42%,and 20.91%;P=0.009,0.002,and 0.046,respectively).The miscarriage rate was similar to that in the control group(4.55%vs.3.33%,P>0.05),and the mean birth weight of the study group was higher than that in the control group(3,556±381 g vs.3,311±570 g,P=0.012).Conclusions:Transfer of frozen day 4,8-cell embryos into endometrial prepared for day 3 embryos can be a new and safe alternative for patients with delayed embryos.

关键词： Extended Culture Frozen Embryo Transfer implantation rate Retarded Embryo Synchronization

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