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Mechanism study of the effect of Ningxue Shengban decoction on regulating the ratio of Treg/Th17 cells and downstream inflammatory factors in immune thrombocytopenia model mice

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Integrative Medicine Discovery 2023年第36期7卷 1-7页

作者： Ai-Di Wang Hong-Lei Guo Dong-Jie Xie Xiang-Yu Zuo Lin Ma Bao-Shan Liu Department of Chinese Medicine Tianjin Medical University General HospitalTianjin 300052China Graduate School Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Oncology the First Affiliated Hospital of Henan University of Science and TechnologyHenan 471003China College of Traditional Chinese Medicine Health Service Shanxi Datong UniversityShanxi 037009China

Background:To explore the role and mechanism of T cell imbalance in the process of immune thrombocytopenic purpura(ITP)and the efficacy of the Ningxue Shengban decoction in treating this ***:Passive immune ITP mouse model was established by injecting CD41 monoclonal antibody into BALB/c *** mice were divided into different groups for intervention and drug administration for 9 *** therapeutic effects(blood cell count,bone marrow morphology)were *** changes in the number and proportion of regulatory T/Th17 cells in each group,as well as the expression of key transcription proteins and genes(Foxp3,RORγt)in mouse spleen,and the secretion of related inflammatory factors(interleukin-17,TGF-β,interleukin-21,interleukin-10)in serum were ***:Ningxue Shengban decoction significantly increased the peripheral blood platelet count in ITP mice,improved bone marrow morphology,restored the imbalance of regulatory T/Th17 ratio,and exerted a positive regulatory effect on target proteins and downstream inflammatory factor ***:Ningxue Shengban decoction may exert its therapeutic effect in treating ITP by regulating T cells and exerting immune regulatory function.

关键词： immune thrombocytopenic purpura immunologic balance traditional Chinese medicine Ningxue Shengban decoction

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